{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:31:44Z","timestamp":1792042304034,"version":"4.4.0"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>Lymphatics play an essential pathophysiological role in promoting fluid and immune cell tissue clearance. Conversely, immune cells may influence lymphatic function and remodeling. Recently, cardiac lymphangiogenesis has been proposed as a therapeutic target to prevent heart failure after myocardial infarction (MI). We investigated the effects of gene therapy to modulate cardiac lymphangiogenesis post-MI in rodents. Second, we determined the impact of cardiac-infiltrating T cells on lymphatic remodeling in the heart.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results:<\/jats:title>\n            <jats:p>\n              Comparing adenoviral versus adeno-associated viral gene delivery in mice, we found that only sustained VEGF (vascular endothelial growth factor)-C\n              <jats:sub>C156S<\/jats:sub>\n              therapy, achieved by adeno-associated viral vectors, increased cardiac lymphangiogenesis, and led to reduced cardiac inflammation and dysfunction by 3 weeks post-MI. Conversely, inhibition of VEGF-C\/-D signaling, through adeno-associated viral delivery of soluble VEGFR3 (vascular endothelial growth factor receptor 3), limited infarct lymphangiogenesis. Unexpectedly, this treatment improved cardiac function post-MI in both mice and rats, linked to reduced infarct thinning due to acute suppression of T-cell infiltration. Finally, using pharmacological, genetic, and antibody-mediated prevention of cardiac T-cell recruitment in mice, we discovered that both CD4\n              <jats:sup>+<\/jats:sup>\n              and CD8\n              <jats:sup>+<\/jats:sup>\n              T cells potently suppress, in part through interferon-\u03b3, cardiac lymphangiogenesis post-MI.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>\n              We show that resolution of cardiac inflammation after MI may be accelerated by therapeutic lymphangiogenesis based on adeno-associated viral gene delivery of VEGF-C\n              <jats:sub>C156S<\/jats:sub>\n              . Conversely, our work uncovers a major negative role of cardiac-recruited T cells on lymphatic remodeling. Our results give new insight into the interconnection between immune cells and lymphatics in orchestration of cardiac repair after injury.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.120.314370","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T09:00:44Z","timestamp":1589446844000},"page":"1722-1737","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":138,"title":["Lymphatic and Immune Cell Cross-Talk Regulates Cardiac Recovery After Experimental Myocardial Infarction"],"prefix":"10.1161","volume":"40","author":[{"given":"Mahmoud","family":"Houssari","sequence":"first","affiliation":[{"name":"From the Normandy University, UniRouen, Inserm (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) UMR1096 (EnVI Laboratory), FHU REMOD-VHF, Rouen, France (H.M., A.D., V.T., I.B., J.P.H., S.R., J.R., S.F., V.R., P.M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anais","family":"Dumesnil","sequence":"additional","affiliation":[{"name":"From the Normandy University, UniRouen, Inserm (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) UMR1096 (EnVI Laboratory), FHU REMOD-VHF, Rouen, France (H.M., A.D., V.T., I.B., J.P.H., S.R., J.R., S.F., V.R., P.M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Tardif","sequence":"additional","affiliation":[{"name":"From the Normandy University, UniRouen, Inserm (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) UMR1096 (EnVI Laboratory), FHU REMOD-VHF, Rouen, France (H.M., A.D., V.T., I.B., J.P.H., S.R., J.R., S.F., V.R., P.M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riikka","family":"Kivel\u00e4","sequence":"additional","affiliation":[{"name":"Wihuri Research Institute and Translational Cancer Biology Program, Research Programs Unit, 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