{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:53:40Z","timestamp":1787018020738,"version":"build-2736575974"},"reference-count":67,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Turner syndrome women (monosomy X) have high risk of aortopathies consistent with a role for sex chromosomes in disease development. We demonstrated that sex chromosomes influence regional development of Ang II (angiotensin II)\u2013induced aortopathies in mice. In this study, we determined if the number of X chromosomes regulates regional development of Ang II\u2013induced aortopathies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results:<\/jats:title>\n                    <jats:p>\n                      We used females with varying numbers of X chromosomes (XX female mice [XXF] or XO female mice [XOF]) on an C57BL\/6J (ascending aortopathies) or low-density lipoprotein receptor deficient (\n                      <jats:italic>Ldlr<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      ) background (descending and abdominal aortopathies) compared with XY males (XYM). To induce aortopathies, mice were infused with Ang II. XOF (C57BL\/6J) exhibited larger percent increases in ascending aortic lumen diameters than Ang II\u2013infused XXF or XYM. Ang II\u2013infused XOF (\n                      <jats:italic>Ldlr<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      ) exhibited similar incidences of thoracic (XOF, 50%; XYM, 71%) and abdominal aortopathies (XOF, 83%; XYM, 71%) as XYM, which were greater than XXF (XXF, 0%). Abdominal aortic lumen diameters and maximal external diameters were similar between XOF and XYM but greater than XXF, and these effects persisted with extended Ang II infusions. Larger aortic lumen diameters, abdominal aortopathy incidence (XXF, 20%; XOF, 75%), and maximal aneurysm diameters (XXF, 1.02\u00b10.17; XOF, 1.96\u00b10.32 mm;\n                      <jats:italic>P<\/jats:italic>\n                      =0.027) persisted in ovariectomized Ang II\u2013infused XOF mice. Data from RNA-seq demonstrated that X chromosome genes that escape X-inactivation (histone lysine demethylases\n                      <jats:italic>Kdm5c<\/jats:italic>\n                      and\n                      <jats:italic>Kdm6a<\/jats:italic>\n                      ) exhibited lower mRNA abundance in aortas of XOF than XXF (\n                      <jats:italic>P<\/jats:italic>\n                      =0.033 and 0.024, respectively). Conversely, DNA methylation was higher in aortas of XOF than XXF (\n                      <jats:italic>P<\/jats:italic>\n                      =0.038).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The absence of a second X chromosome promotes diffuse Ang II\u2013induced aortopathies in females.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/atvbaha.120.314407","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T05:01:35Z","timestamp":1602738095000},"page":"269-283","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Monosomy X in Female Mice Influences the Regional Formation and Augments the Severity of Angiotensin II\u2013Induced Aortopathies"],"prefix":"10.1161","volume":"41","author":[{"given":"Yasir","family":"AlSiraj","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences (Y.A., S.E.T., E.B., L.A.C.), University of Kentucky, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1952-4459","authenticated-orcid":true,"given":"Sean E.","family":"Thatcher","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences (Y.A., S.E.T., E.B., L.A.C.), University of Kentucky, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Blalock","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences (Y.A., S.E.T., E.B., L.A.C.), University of Kentucky, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley N.","family":"Saintilnord","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biochemistry (W.N.S.), University of Kentucky, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Daugherty","sequence":"additional","affiliation":[{"name":"Department of Physiology (A.D., H.S.L.), University of Kentucky, Lexington."},{"name":"Saha Cardiovascular Research Center (A.D., H.S.L.), University of Kentucky, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong S.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Physiology (A.D., H.S.L.), University of Kentucky, Lexington."},{"name":"Saha Cardiovascular Research Center (A.D., H.S.L.), University of Kentucky, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Luo","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, and Department of Cardiovascular Surgery, Texas Heart Institute, Houston (W.L., Y.H.S., S.A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying H.","family":"Shen","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, and Department of Cardiovascular Surgery, Texas Heart Institute, Houston (W.L., Y.H.S., S.A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"LeMaire","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, and Department of Cardiovascular Surgery, Texas Heart Institute, Houston (W.L., Y.H.S., S.A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur P.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Integrative Biology and Physiology, University of California, Los Angeles (A.P.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Cassis","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences (Y.A., S.E.T., E.B., L.A.C.), University of Kentucky, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/hco.0b013e3283129b89"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2018-0346"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-018-0497-0"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.bsd.0000211278.83647.9e"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.088633"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685487"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307301"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.2310\/6670.2008.00092"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.116.001647"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2017.14489"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1615"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.160382"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.310035"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.05.014"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.253880"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023789"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000133152"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-016-0115-5"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000014954"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10462-z"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000150540.54220.C4"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-3-r25"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-0802"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780090710"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.207702"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305482"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307613"},{"key":"e_1_3_5_33_2","first-page":"1099","article-title":"Hypercholesterolemia accelerates both the initiation and progression of angiotensin II-induced abdominal aortic aneurysms.","volume":"6","author":"Liu J","year":"2020","unstructured":"Liu, J, Sawada, H, Howatt, DA, Moorleghen, JJ, Vsevolozhskaya, O, Daugherty, A, Lu, HS. 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