{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:58:00Z","timestamp":1792900680818,"version":"4.5.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>\n              Adrenal gland secretes stress-induced glucocorticoids (iGCs) to coping with stress. Previous study showed that SR-BI (scavenger receptor BI) null (SR-BI\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              ) mice failed to generate iGC in stress conditions, suggesting that SR-BI\u2013mediated cholesterol uptake from HDL (high-density lipoprotein) is a key regulator for iGC production. However, the LDL (low-density lipoprotein)\/LDLr (LDL receptor) pathway can also provide cholesterol for iGC synthesis, but rodents have limited LDL levels in circulation. Here, we generated SR-BI\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              ApoBtg (apolipoprotein B transgenic) mice with normal LDL levels in circulation to determine the relative contribution of the HDL\/SR-BI and LDL\/LDLr pathways to iGC production in stress conditions.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results:<\/jats:title>\n            <jats:p>\n              To obtain mouse models with normal LDL levels, SR-BI\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice were bred to ApoBtg mice. Then, the F1 SR-BI\u00b1ApoBtg mice were backcrossed to SR-BI\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              to obtain SR-BI\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              ApoBtg, SR-BI\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              ApoBwt (apolipoprotein B wild type), and SR-BI\n              <jats:sup>+\/+<\/jats:sup>\n              ApoBtg mice. We first examined the lipoprotein profile, which shows a 6.5-fold increase in LDL levels in SR-BI\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              ApoBtg mice compared with SR-BI\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              ApoBwt mice. Then, we induced stress with adrenocorticotropic hormone and cecal ligation and puncture. One hour after adrenocorticotropic hormone stimulation, SR-BI\n              <jats:sup>+\/+<\/jats:sup>\n              ApoBtg control mice produced iGC (14.9-fold), but both SR-BI\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              ApoBwt and SR-BI\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              ApoBtg showed no iGC production (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Three hours after cecal ligation and puncture treatment, SR-BI\n              <jats:sup>+\/+<\/jats:sup>\n              ApoBtg control mice showed iGC production (6.4-fold), but both SR-BI\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              ApoBwt and SR-BI\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              ApoBtg mice showed no iGC production (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>\n              SR-BI\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              ApoBtg mice fail to produce iGC in stress conditions even though with restored LDL levels in circulation. These findings clarify that the HDL\/SR-BI, not LDL\/LDLr, pathway is responsible for iGC production in stress conditions.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.120.314506","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T09:00:17Z","timestamp":1591866017000},"page":"1830-1837","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["SR-BI (Scavenger Receptor BI), Not LDL (Low-Density Lipoprotein) Receptor, Mediates Adrenal Stress Response\u2014Brief Report"],"prefix":"10.1161","volume":"40","author":[{"given":"Misa","family":"Ito","sequence":"first","affiliation":[{"name":"From the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington."},{"name":"Department of Pharmacology and Nutritional Sciences (M.I., D. Hao, A.D., X.-A.L.), University of Kentucky College of Medicine, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Ye","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Guo","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Hao","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington."},{"name":"Department of Pharmacology and Nutritional Sciences (M.I., D. Hao, A.D., X.-A.L.), University of Kentucky College of Medicine, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Howatt","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Daugherty","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington."},{"name":"Department of Pharmacology and Nutritional Sciences (M.I., D. Hao, A.D., X.-A.L.), University of Kentucky College of Medicine, Lexington."},{"name":"Department of Physiology (A.D., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cai","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Temel","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington."},{"name":"Department of Physiology (A.D., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6899-7332","authenticated-orcid":true,"given":"Xiang-An","family":"Li","sequence":"additional","affiliation":[{"name":"From the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington."},{"name":"Department of Pharmacology and Nutritional Sciences (M.I., D. Hao, A.D., X.-A.L.), University of Kentucky College of Medicine, Lexington."},{"name":"Department of Physiology (A.D., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.07.003"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.04.005"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-2045"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.11.005"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31539"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000219310.00308.10"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.020933"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001264"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303164"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)40133-5"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.12.4329"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)70388-3"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0650099"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(83)90075-6"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00428.2006"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(85)90132-5"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2001-0037"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000046"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.46.27"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907687"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad3517"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700475-JLR200"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300784"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116927"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(92)90203-s"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-15-0023"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.120.314506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:41:26Z","timestamp":1715557286000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.120.314506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1161\/ATVBAHA.120.314506"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.120.314506","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"2020-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}