{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:43:29Z","timestamp":1787496209884,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the prevalence of D-dimer elevation in coronavirus disease 2019 (COVID-19) hospitalization, trajectory of D-dimer levels during hospitalization, and its association with clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results:<\/jats:title>\n                    <jats:p>\n                      Consecutive adults admitted to a large New York City hospital system with a positive polymerase chain reaction test for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) between March 1, 2020 and April 8, 2020 were identified. Elevated D-dimer was defined by the laboratory-specific upper limit of normal (&gt;230 ng\/mL). Outcomes included critical illness (intensive care, mechanical ventilation, discharge to hospice, or death), thrombotic events, acute kidney injury, and death during admission. Among 2377 adults hospitalized with COVID-19 and \u22651 D-dimer measurement, 1823 (76%) had elevated D-dimer at presentation. Patients with elevated presenting baseline D-dimer were more likely than those with normal D-dimer to have critical illness (43.9% versus 18.5%; adjusted odds ratio, 2.4 [95% CI, 1.9\u20133.1];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), any thrombotic event (19.4% versus 10.2%; adjusted odds ratio, 1.9 [95% CI, 1.4\u20132.6];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), acute kidney injury (42.4% versus 19.0%; adjusted odds ratio, 2.4 [95% CI, 1.9\u20133.1];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), and death (29.9% versus 10.8%; adjusted odds ratio, 2.1 [95% CI, 1.6\u20132.9];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Rates of adverse events increased with the magnitude of D-dimer elevation; individuals with presenting D-dimer &gt;2000 ng\/mL had the highest risk of critical illness (66%), thrombotic event (37.8%), acute kidney injury (58.3%), and death (47%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Abnormal D-dimer was frequently observed at admission with COVID-19 and was associated with higher incidence of critical illness, thrombotic events, acute kidney injury, and death. The optimal management of patients with elevated D-dimer in COVID-19 requires further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/atvbaha.120.314872","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T09:23:18Z","timestamp":1598347398000},"page":"2539-2547","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":156,"title":["Prevalence and Outcomes of D-Dimer Elevation in Hospitalized Patients With COVID-19"],"prefix":"10.1161","volume":"40","author":[{"given":"Jeffrey S.","family":"Berger","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. Horowitz, C.P., H.R., J.S., E.Y., J. Hochman)."},{"name":"Center for Prevention of Cardiovascular Disease (J.S.B.), NYU Langone Health, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Kunichoff","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Population Health, New York (D.K., S.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9954-5999","authenticated-orcid":true,"given":"Samrachana","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Population Health, New York (D.K., S.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1833-4124","authenticated-orcid":true,"given":"Tania","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Pharmacy (T.A.), NYU Langone Health, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Amoroso","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Critical Care, Department of Medicine, New York (N.A., S.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yindalon","family":"Aphinyanaphongs","sequence":"additional","affiliation":[{"name":"Center for Healthcare Innovation and Delivery Science, New York (Y.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Cao","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine and Clinical Innovation, Department of Medicine, New York (M.C., C.P., L.I.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Goldenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hindenburg","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, NYU Winthrop Hospital, Mineola, NY (A.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8220-5434","authenticated-orcid":true,"given":"James","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York (J.S.B., J. 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