{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:33:42Z","timestamp":1789594422534,"version":"build-2803163510"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Acute peripheral arterial events, such as aortic dissection, carotid artery dissection, vertebral artery dissection, and ruptured renoviseral aneurysms, have been reported during pregnancy in case series, but there is a paucity of population-based data. This study sought to establish pregnancy and preeclampsia as risk factors for acute peripheral arterial events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results:<\/jats:title>\n                    <jats:p>\n                      All women who gave birth between 1998 and 2020 within a multicenter health care system were identified. Births that occurred in women &lt;18 or &gt;50 years of age were excluded. Primary outcome was any acute peripheral arterial event that was symptomatic or required intervention. Cox regression model was used to evaluate the association between vascular events and pregnancy as a time-varying covariate. The pregnancy exposure period was from the estimated date of conception to 3 months postpartum. There were 277\u2009697 pregnancies (81.3% deliveries, 17.0% abortions, and 1.7% ectopics) among 176\u2009635 women with 1.68 million patient-years of total follow-up (median, 7.9 years; interquartile range, 2.4\u201316.2). Preeclampsia complicated 5.3% of pregnancies; 67\u2009790 of 225\u2009763 (30.0%) deliveries were delivered by cesarean. Ninety-six acute arterial events occurred during follow-up, of which 24 occurred during pregnancy, including the postpartum period. Pregnancy (hazard ratio, 1.85 [95% CI, 1.01\u20133.38];\n                      <jats:italic>P<\/jats:italic>\n                      =0.046) and preeclampsia (hazard ratio, 10.9 [95% CI, 5.24\u201322.7];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) were significant independent predictors of acute arterial events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>While taking into account limitations from estimating conception and outcome dates, pregnancy, especially when complicated by preeclampsia, is associated with an increased risk of acute peripheral arterial events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/atvbaha.120.315174","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T05:01:35Z","timestamp":1602738095000},"page":"526-533","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Pregnancy and Preeclampsia Are Associated With Acute Adverse Peripheral Arterial Events"],"prefix":"10.1161","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7785-941X","authenticated-orcid":true,"given":"Charles","family":"DeCarlo","sequence":"first","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery (C.D., L.T.B., M.F.C., M.J.E., A.D.), Massachusetts General Hospital, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura T.","family":"Boitano","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery (C.D., L.T.B., M.F.C., M.J.E., A.D.), Massachusetts General Hospital, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7977-7960","authenticated-orcid":true,"given":"Rose L.","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA (R.L.M.)."},{"name":"Division of Women\u2019s Health, Brigham and Women\u2019s Hospital, Boston, MA (R.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ido","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Fireman Vascular Center (I.W.), Massachusetts General Hospital, Boston."},{"name":"Department of Medicine, Division of Vascular Medicine (I.W.), Massachusetts General Hospital, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark F.","family":"Conrad","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery (C.D., L.T.B., M.F.C., M.J.E., A.D.), Massachusetts General Hospital, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Eagleton","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery (C.D., L.T.B., M.F.C., M.J.E., A.D.), Massachusetts General Hospital, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahita","family":"Dua","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery (C.D., L.T.B., M.F.C., M.J.E., A.D.), Massachusetts General Hospital, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199609123351102"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.576751"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311485"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-12-122"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000433-200212000-00007"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(03)00169-3"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2001.109767"},{"key":"e_1_3_4_9_2","first-page":"bcr2013202541","article-title":"A young pregnant woman with spontaneous carotid artery dissection--unknown mechanisms.","volume":"2014","author":"Mohammed I","year":"2014","unstructured":"Mohammed, I, Aaland, M, Khan, N, Crossley, I. 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