{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T22:01:37Z","timestamp":1774648897938,"version":"3.50.1"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>To determine the effects of HIV serostatus and disease severity on endothelial function in a large pooled cohort study of people living with HIV infection and HIV\u2212 controls.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results:<\/jats:title>\n            <jats:p>\n              We used participant-level data from 9 studies: 7 included people living with HIV (2 treatment-na\u00efve) and 4 had HIV\u2212 controls. Brachial artery flow-mediated dilation (FMD) was measured using a standardized ultrasound imaging protocol with central reading. After data harmonization, multiple linear regression was used to examine the effects of HIV\u2212 serostatus, HIV disease severity measures, and cardiovascular disease risk factors on FMD. Of 2533 participants, 986 were people living with HIV (mean 44.4 [SD 11.8] years old) and 1547 were HIV\u2212 controls (42.9 [12.2] years old). The strongest and most consistent associates of FMD were brachial artery diameter, age, sex, and body mass index. The effect of HIV+ serostatus on FMD was strongly influenced by kidney function. In the highest tertile of creatinine (1.0 mg\/dL), the effect of HIV+ serostatus was strong (\u03b2=\u22121.59% [95% CI, \u22122.58% to \u22120.60%],\n              <jats:italic>P<\/jats:italic>\n              =0.002), even after covariate adjustment (\u03b2=\u22121.36% [95% CI, \u22122.46% to \u22120.47%],\n              <jats:italic>P<\/jats:italic>\n              =0.003). In the lowest tertile (0.8 mg\/dL), the effect of HIV+ serostatus was strong (\u03b2=\u22121.90% [95% CI, \u22122.58% to \u22121.21%],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), but disappeared after covariate adjustment. HIV RNA viremia, CD4+ T-cell count, and use of antiretroviral therapy were not meaningfully associated with FMD.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The significant effect of HIV+ serostatus on FMD suggests that people living with HIV are at increased cardiovascular disease risk, especially if they have kidney disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.120.315435","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T10:20:35Z","timestamp":1608200435000},"page":"512-522","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of HIV Infection on Arterial Endothelial Function"],"prefix":"10.1161","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2770-8223","authenticated-orcid":true,"given":"James H.","family":"Stein","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison (J.H.S., C.E.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7379-0531","authenticated-orcid":true,"given":"Noah","family":"Kime","sequence":"additional","affiliation":[{"name":"University of Washington Collaborative Health Studies Coordinating Center, Seattle (N.K., J.C.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9691-9027","authenticated-orcid":true,"given":"Claudia E.","family":"Korcarz","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison (J.H.S., C.E.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Ribaudo","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T.H. 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