{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:15:52Z","timestamp":1792556152349,"version":"4.5.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Carmat bioprosthetic total artificial heart (Aeson; A-TAH) is a pulsatile and autoregulated device. The aim of this study is to evaluate level of hemolysis potential acquired von Willebrand syndrome after A-TAH implantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We examined the presence of hemolysis and acquired von Willebrand syndrome in adult patients receiving A-TAH support (n=10) during their whole clinical follow-up in comparison with control subjects and adult patients receiving Heartmate II or Heartmate III support. We also performed a fluid structure interaction model coupled with computational fluid dynamics simulation to evaluate the A-TAH resulting shear stress and its distribution in the blood volume.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              The cumulative duration of A-TAH support was 2087 days. A-TAH implantation did not affect plasma free hemoglobin over time, and there was no association between plasma free hemoglobin and cardiac output or beat rate. For VWF (von Willebrand factor) evaluation, A-TAH implantation did not modify multimers profile of VWF in contrast to Heartmate II and Heartmate III. Furthermore, fluid structure interaction coupled with computational fluid dynamics showed a gradually increase of blood damage according to increase of cardiac output (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01), however, the blood volume fraction that endured significant shear stresses was always inferior to 0.03% of the volume for both ventricles in all regimens tested. An inverse association between cardiac output, beat rate, and high-molecular weight multimers ratio was found.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>We demonstrated that A-TAH does not cause hemolysis or AWVS. However, relationship between HMWM and cardiac output depending flow confirms relevance of VWF as a biological sensor of blood flow, even in normal range.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.121.316833","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T10:00:23Z","timestamp":1644487223000},"page":"470-480","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Bioprosthetic Total Artificial Heart in Autoregulated Mode Is Biologically Hemocompatible: Insights for Multimers of von Willebrand Factor"],"prefix":"10.1161","volume":"42","author":[{"given":"Bastien","family":"Poitier","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, Innovative Therapies in Hemostasis, INSERM, F-75006 Paris, France (B.P., A.C., C.L.)."},{"name":"Cardiac Surgery Department and Biosurgical Research lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, France (B.P., A.C., C.L.)."},{"name":"Carmat SAS, Velizy-Villacoublay, France (B.P., U.R., M.G., A.C., P.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5498-8937","authenticated-orcid":true,"given":"Richard","family":"Chocron","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, PARCC, INSERM, F-75015 Paris, France, Emergency department, AP-HP, Georges Pompidou European Hospital, France (R.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Peronino","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Innovative Therapies in Hemostasis, INSERM, F-75006 Paris, France, Hematology department and Biosurgical Research lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, France (C.P., A.P., N.R., U.R., N.G., J.B., J.R., D.M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Philippe","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Innovative Therapies in Hemostasis, INSERM, F-75006 Paris, France, Hematology department and Biosurgical Research lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, France (C.P., A.P., N.R., U.R., N.G., J.B., J.R., D.M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Pya","sequence":"additional","affiliation":[{"name":"National Research Cardiac, Surgery Center, Nur-Sultan, Kazakhstan (Y.P., M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Rivet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Innovative Therapies in Hemostasis, INSERM, F-75006 Paris, France, Hematology department and Biosurgical Research lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, France (C.P., A.P., N.R., U.R., N.G., J.B., J.R., D.M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulysse","family":"Richez","sequence":"additional","affiliation":[{"name":"Carmat SAS, Velizy-Villacoublay, France (B.P., U.R., M.G., A.C., P.J.)."},{"name":"Universit\u00e9 de Paris, Innovative Therapies in Hemostasis, INSERM, F-75006 Paris, France, Hematology department and Biosurgical Research lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, France (C.P., A.P., N.R., U.R., N.G., J.B., J.R., D.M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2834-617X","authenticated-orcid":true,"given":"Mahabbat","family":"Bekbossynova","sequence":"additional","affiliation":[{"name":"National Research Cardiac, Surgery Center, Nur-Sultan, Kazakhstan (Y.P., M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4852-4738","authenticated-orcid":true,"given":"Nicolas","family":"Gendron","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Innovative Therapies in Hemostasis, INSERM, F-75006 Paris, France, Hematology department and Biosurgical Research lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, France (C.P., A.P., N.R., U.R., N.G., J.B., J.R., D.M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-4858","authenticated-orcid":true,"given":"Marc","family":"Grimm\u00e9","sequence":"additional","affiliation":[{"name":"Carmat SAS, Velizy-Villacoublay, France (B.P., U.R., M.G., A.C., P.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie C\u00e9cile","family":"Bories","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Cardiac Surgery Department, AP-HP, Georges Pompidou European Hospital, France (M.C.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Brichet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Innovative Therapies in Hemostasis, INSERM, F-75006 Paris, France, Hematology department and Biosurgical Research lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, France (C.P., A.P., N.R., U.R., N.G., J.B., J.R., D.M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Capel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Innovative Therapies in Hemostasis, INSERM, F-75006 Paris, France (B.P., A.C., C.L.)."},{"name":"Cardiac Surgery Department and Biosurgical Research lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, France (B.P., A.C., C.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Rancic","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Innovative Therapies in Hemostasis, INSERM, F-75006 Paris, France, Hematology department and Biosurgical Research lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, France (C.P., A.P., N.R., U.R., N.G., J.B., J.R., D.M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-5356","authenticated-orcid":true,"given":"Benoit","family":"Vedie","sequence":"additional","affiliation":[{"name":"AP-HP, Biochemistry Department, Georges Pompidou European Hospital, France (B.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3928-6977","authenticated-orcid":true,"given":"Jean Christian","family":"Roussel","sequence":"additional","affiliation":[{"name":"Cardiac and thoracic Surgery Department, CHU de Nantes, h\u00f4pital Nord La\u00ebnnec, boulevard Jacques-Monod, France (J.C.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Jannot","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique-H\u00f4pitaux de Paris, Paris, France (A.-S.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Carpentier","sequence":"additional","affiliation":[{"name":"Carmat SAS, Velizy-Villacoublay, France (B.P., U.R., M.G., A.C., P.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ivak","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (P.I., I.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Latremouille","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Innovative Therapies in Hemostasis, INSERM, F-75006 Paris, France (B.P., A.C., C.L.)."},{"name":"Cardiac Surgery Department and Biosurgical Research lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, France (B.P., A.C., C.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Netuka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (P.I., I.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7731-9202","authenticated-orcid":true,"given":"David M.","family":"Smadja","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Innovative Therapies in Hemostasis, INSERM, F-75006 Paris, France, Hematology department and Biosurgical Research lab (Carpentier Foundation), AP-HP, Georges Pompidou European Hospital, France (C.P., A.P., N.R., U.R., N.G., J.B., J.R., D.M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.14319"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-528406"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.075"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.05.060"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.09.031"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60511-6"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.05.021"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.09.002"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.06.018"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.07.004"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22416"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12141"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-020-09762-6"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-021-09803-8"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v98.6.1765"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV17031"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12116"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13316"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2017.04.004"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02914"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1660481"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/1076029612464900"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000206"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012175"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909938"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.4007092"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.4084\/MJHID.2013.060"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-01-769018"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.05.019"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028303"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.05.006"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006519"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.12.047"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.03.010"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2017.02.184"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2004.07265.x"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115124"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V71.5.1366.1366"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt228"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.07.072"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-636480"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.06.049"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2021.05.013"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-019-01474-2"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1713751"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.121.316833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:40:26Z","timestamp":1715557226000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.121.316833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1161\/ATVBAHA.121.316833"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.121.316833","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"2021-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}