{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:19:16Z","timestamp":1790655556759,"version":"4.1.0"},"reference-count":64,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Alterations in gut microbiota and blood metabolomic profiles have been implicated in HIV infection and cardiovascular disease. However, it remains unclear whether alterations in gut microbiota may contribute to disrupted host blood metabolomic profiles in relation to atherosclerosis, especially in the context of HIV infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed cross-sectional associations between gut microbiota features and carotid artery plaque in 361 women with or at high risk of HIV (67% HIV+), and further integrated plaque-associated microbial features with plasma lipidomic\/metabolomic profiles. Furthermore, in 737 women and men, we examined prospective associations of baseline gut bacteria-associated lipidomic and metabolomic profiles with incident carotid artery plaque over 7-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We found 2 potentially pathogenic bacteria,\n                      <jats:italic>Fusobacterium<\/jats:italic>\n                      and\n                      <jats:italic>Proteus<\/jats:italic>\n                      , were associated with carotid artery plaque; while the beneficial butyrate producer\n                      <jats:italic>Odoribacter<\/jats:italic>\n                      was inversely associated with plaque.\n                      <jats:italic>Fusobacterium<\/jats:italic>\n                      and\n                      <jats:italic>Proteus<\/jats:italic>\n                      were associated with multiple lipids\/metabolites which were clustered into 8 modules in network. A module comprised of 9 lysophosphatidylcholines and lysophosphatidylethanolamines and a module comprised of 9 diglycerides were associated with increased risk of carotid artery plaque (risk ratio [95% CI], 1.34 [1.09\u20131.64] and 1.24 [1.02\u20131.51] per SD increment, respectively). Functional analyses identified bacterial enzymes in lipid metabolism associated with these plasma lipids. In particular, phospholipase A1 and A2 are the key enzymes in the reactions producing lysophosphatidylcholines and lysophosphatidylethanolamines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Among individuals with or at high risk of HIV infection, we identified altered gut microbiota and related functional capacities in the lipid metabolism associated with disrupted plasma lipidomic profiles and carotid artery atherosclerosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/atvbaha.121.317276","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T05:00:22Z","timestamp":1654750822000},"page":"1081-1093","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["Gut Microbiota, Plasma Metabolomic Profiles, and Carotid Artery Atherosclerosis in HIV Infection"],"prefix":"10.1161","volume":"42","author":[{"given":"Zheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Population Health (Z.W., B.A.P., J.X., D.B.H., T.W., K.A., R.C.K., R.D.B., Q.Q.), Albert Einstein College of Medicine, Bronx, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1534-2578","authenticated-orcid":true,"given":"Brandilyn A.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health (Z.W., B.A.P., J.X., D.B.H., T.W., K.A., R.C.K., R.D.B., Q.Q.), Albert Einstein College of Medicine, Bronx, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mykhaylo","family":"Usyk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (M.U., R.D.B.), Albert Einstein College of Medicine, Bronx, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqian","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health (Z.W., B.A.P., J.X., D.B.H., T.W., K.A., R.C.K., R.D.B., Q.Q.), Albert Einstein College of Medicine, Bronx, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health (Z.W., B.A.P., J.X., D.B.H., T.W., K.A., R.C.K., R.D.B., Q.Q.), Albert Einstein College of Medicine, Bronx, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health (Z.W., B.A.P., J.X., D.B.H., T.W., K.A., R.C.K., R.D.B., Q.Q.), Albert Einstein College of Medicine, Bronx, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8655-5204","authenticated-orcid":true,"given":"Wendy S.","family":"Post","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University, Baltimore, MD (W.S.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan L.","family":"Landay","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rush University Medical Center, Chicago, IL (A.L.L)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard N.","family":"Hodis","sequence":"additional","affiliation":[{"name":"Atherosclerosis Research Unit, Keck School of Medicine, University of Southern California, Los Angeles (H.N.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Weber","sequence":"additional","affiliation":[{"name":"Hektoen Institute of Medicine, Chicago, IL (K.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"French","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, John H. 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