{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T11:29:27Z","timestamp":1770463767545,"version":"3.49.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Thrombo-inflammation is central to COVID-19-associated coagulopathy. TF (tissue factor), a driver of disordered coagulation and inflammation in viral infections, may be a therapeutic target in COVID-19. The safety and efficacy of the novel TF inhibitor rNAPc2 (recombinant nematode anticoagulation protein c2) in COVID-19 are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>ASPEN-COVID-19 was an international, randomized, open-label, active comparator clinical trial with blinded end point adjudication. Hospitalized patients with COVID-19 and elevated D-dimer levels were randomized 1:1:2 to lower or higher dose rNAPc2 on days 1, 3, and 5 followed by heparin on day 8 or to heparin per local standard of care. In comparisons of the pooled rNAPc2 versus heparin groups, the primary safety end point was major or nonmajor clinically relevant International Society of Thrombosis and Haemostasis bleeding through day 8. The primary efficacy end point was proportional change in D-dimer concentration from baseline to day 8, or discharge if before day 8. Patients were followed for 30 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Among 160 randomized patients, median age was 54 years, 43.1% were female, and 38.8% had severe baseline COVID-19. There were no significant differences between rNAPc2 and heparin in bleeding or other safety events. Overall, median change in D-dimer was \u221216.8% (interquartile range, \u221245.7 to 36.8;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.41) with rNAPc2 treatment and \u221211.2% (\u221236.0 to 34.4;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.91) with heparin (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:sub>intergroup<\/jats:sub>\n                      =0.47). In prespecified analyses, in severely ill patients, D-dimer levels tended to increase more within the heparin (median, 29.0% [\u221214.9 to 145.2];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.02) than the rNAPc2 group (median, 25.9% [\u221249.1 to 136.4];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.14;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:sub>intergroup<\/jats:sub>\n                      =0.96); in mildly ill patients, D-dimer levels were reduced within each group with a numerically greater reduction with rNAPc2 versus heparin (rNAPc2 median, \u221232.7% [\u221244.7 to 4.3];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.007 and heparin median, \u221216.8% [\u221236.0 to 0.5];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.008,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:sub>intergroup<\/jats:sub>\n                      =0.34).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>rNAPc2 treatment in hospitalized patients with COVID-19 was well tolerated without excess bleeding or serious adverse events but did not significantly reduce D-dimer more than heparin at day 8.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT04655586.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/atvbaha.122.318748","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T05:00:24Z","timestamp":1688014824000},"page":"1572-1582","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Novel Tissue Factor Inhibition for Thromboprophylaxis in COVID-19: Primary Results of the ASPEN-COVID-19 Trial"],"prefix":"10.1161","volume":"43","clinical-trial-number":[{"clinical-trial-number":"nct04655586","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5830-0511","authenticated-orcid":true,"given":"Connie N.","family":"Hess","sequence":"first","affiliation":[{"name":"Department of Medicine (C.N.H., J.H., M.S., W.H.C., M.R.B., M.P.B.), University of Colorado, Aurora."},{"name":"CPC Clinical Research, Aurora, CO (C.N.H., J.H., M.R.N., M.S., W.H.C., R.G., 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