{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:05:03Z","timestamp":1784081103958,"version":"3.55.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>\n              Assessments of coronary disease activity with\n              <jats:sup>18<\/jats:sup>\n              F-sodium fluoride positron emission tomography and radiomics-based precision coronary plaque phenotyping derived from coronary computed tomography angiography may enhance risk stratification in patients with coronary artery disease. We sought to investigate whether the prognostic information provided by these 2 approaches is complementary in the prediction of myocardial infarction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              Patients with known coronary artery disease underwent coronary\n              <jats:sup>18<\/jats:sup>\n              F-sodium fluoride positron emission tomography and coronary computed tomography angiography on a hybrid positron emission tomography\/computed tomography scanner. Coronary\n              <jats:sup>18<\/jats:sup>\n              F-NaF uptake was determined by the coronary microcalcification activity. We performed quantitative plaque analysis of coronary computed tomography angiography datasets and extracted 1103 radiomic features for each plaque. Using weighted correlation network analysis, we derived latent morphological features of coronary lesions which were aggregated to patient-level radiomics nomograms to predict myocardial infarction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Among 260 patients with established coronary artery disease (age, 65\u00b19 years; 83% men), 179 (69%) participants showed increased coronary\n              <jats:sup>18<\/jats:sup>\n              F-NaF activity (coronary microcalcification activity&gt;0). Over 53 (40\u201359) months of follow-up, 18 patients had a myocardial infarction. Using weighted correlation network analysis, we derived 15 distinct eigen radiomic features representing latent morphological coronary plaque patterns in an unsupervised fashion. Following adjustments for calcified, noncalcified, and low-density noncalcified plaque volumes and\n              <jats:sup>18<\/jats:sup>\n              F-NaF coronary microcalcification activity, 4 radiomic features remained independent predictors of myocardial infarction (hazard ratio, 1.46 [95% CI, 1.03\u20132.08];\n              <jats:italic>P<\/jats:italic>\n              =0.03; hazard ratio, 1.62 [95% CI, 1.04\u20132.54];\n              <jats:italic>P<\/jats:italic>\n              =0.02; hazard ratio, 1.49 [95% CI, 1.07\u20132.06];\n              <jats:italic>P<\/jats:italic>\n              =0.01; and hazard ratio, 1.50 (95% CI, 1.05\u20132.13);\n              <jats:italic>P<\/jats:italic>\n              =0.02).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>\n              In patients with established coronary artery disease, latent coronary plaque morphological features, quantitative plaque volumes, and disease activity on\n              <jats:sup>18<\/jats:sup>\n              F-sodium fluoride positron emission tomography are additive predictors of myocardial infarction.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.123.319332","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T09:01:40Z","timestamp":1683795700000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Latent Coronary Plaque Morphology From Computed Tomography Angiography, Molecular Disease Activity on Positron Emission Tomography, and Clinical Outcomes"],"prefix":"10.1161","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8202-6359","authenticated-orcid":true,"given":"Jacek","family":"Kwiecinski","sequence":"first","affiliation":[{"name":"Departments of Medicine (Artificial Intelligence in Medicine), Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA (J.K., E.T., D.S.B., D.D., P.J.S.)."},{"name":"Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5570-991X","authenticated-orcid":true,"given":"M\u00e1rton","family":"Kolossv\u00e1ry","sequence":"additional","affiliation":[{"name":"Gottsegen National Cardiovascular Center, Budapest, Hungary (M.K.)."},{"name":"Physiological Controls Research Center, University Research and Innovation Center, \u00d3buda University, Budapest, Hungary (M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0038-043X","authenticated-orcid":true,"given":"Evangelos","family":"Tzolos","sequence":"additional","affiliation":[{"name":"Departments of Medicine (Artificial Intelligence in Medicine), Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA (J.K., E.T., D.S.B., D.D., P.J.S.)."},{"name":"BHF Centre for Cardiovascular Science (E.T., M.N.M., M.C.W., E.J.R.v.B., D.E.N., M.R.B.), University of Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0806-9972","authenticated-orcid":true,"given":"Mohammed N.","family":"Meah","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science (E.T., M.N.M., M.C.W., E.J.R.v.B., D.E.N., M.R.B.), University of Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6177-956X","authenticated-orcid":true,"given":"Philip D.","family":"Adamson","sequence":"additional","affiliation":[{"name":"Christchurch Heart Institute, University of Otago, Christchurch, New Zealand (P.D.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil V.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Bristol Heart Institute, University of Bristol, United Kingdom (N.V.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3556-2428","authenticated-orcid":true,"given":"Michelle C.","family":"Williams","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science (E.T., M.N.M., M.C.W., E.J.R.v.B., D.E.N., M.R.B.), University of Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2777-5071","authenticated-orcid":true,"given":"Edwin J.R.","family":"van Beek","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science (E.T., M.N.M., M.C.W., E.J.R.v.B., D.E.N., M.R.B.), University of Edinburgh, United Kingdom."},{"name":"Edinburgh Imaging, Queens Medical Research Institute (E.J.R.v.B.), University of Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Berman","sequence":"additional","affiliation":[{"name":"Departments of Medicine (Artificial Intelligence in Medicine), Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA (J.K., E.T., D.S.B., D.D., P.J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e1l","family":"Maurovich-Horvat","sequence":"additional","affiliation":[{"name":"MTA-SE Cardiovascular Imaging Research Group, Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary (P.M.-H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7971-4628","authenticated-orcid":true,"given":"David E.","family":"Newby","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science (E.T., M.N.M., M.C.W., E.J.R.v.B., D.E.N., M.R.B.), University of Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9847-5917","authenticated-orcid":true,"given":"Marc R.","family":"Dweck","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science (E.T., M.N.M., M.C.W., E.J.R.v.B., D.E.N., M.R.B.), University of Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2236-6970","authenticated-orcid":true,"given":"Damini","family":"Dey","sequence":"additional","affiliation":[{"name":"Departments of Medicine (Artificial Intelligence in Medicine), Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA (J.K., E.T., D.S.B., D.D., P.J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6110-938X","authenticated-orcid":true,"given":"Piotr J.","family":"Slomka","sequence":"additional","affiliation":[{"name":"Departments of Medicine (Artificial Intelligence in Medicine), Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA (J.K., E.T., D.S.B., D.D., P.J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.046"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61754-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262283"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010224"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.11.016"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044720"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2589-7500(22)00022-x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.2631"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jez033"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019190407"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.05.023"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.120.011438"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-303640"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.118.008325"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-018-01542-6"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04437-x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04667-z"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-020-02221-1"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2014.07.003"},{"key":"e_1_3_3_21_2","unstructured":"Kolossvary M. 2021 RIA: Radiomics Image Analysis Toolbox for Grayscale Images. https:\/\/cran.r-project.org\/web\/packages\/RIA\/index.html"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-08894-1"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.2202\/1544-6115.1128"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v082.i13"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v046.i11"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3294-8"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1214\/08-AOAS169"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019190928"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018172361"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262304"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.118.008513"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.053"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.12.056"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.056891"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8495"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.313785"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311711"},{"key":"e_1_3_3_39_2","unstructured":"ClinicalTrials.gov. National Library of Medicine (U.S.). Effect of Evolocumab on Coronary Artery Plaque Volume and Composition by CCTA and Microcalcification by F18-NaF PET. 2018. Accessed March 4 2023. https:\/\/ClinicalTrials.gov\/show\/NCT03689946."}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.123.319332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:38:14Z","timestamp":1715557094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.123.319332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1161\/ATVBAHA.123.319332"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.123.319332","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2023-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}