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Increased study is needed on the structure-function relationship to resolve many unknowns regarding AGT metabolism. Constitutive whole-body genetic deletion of\n            <jats:italic toggle=\"yes\">Agt<\/jats:italic>\n            in mice leads to multiple developmental defects creating a challenge to use these mice for mechanistic studies. This has been overcome by creating\n            <jats:italic toggle=\"yes\">Agt<\/jats:italic>\n            -floxed mice to enable the development of cell-specific deficiencies that have provided considerable insight into a range of cardiovascular and associated diseases. This has been augmented by the recent development of pharmacological approaches targeting hepatocytes in humans to promote protracted inhibition of AGT synthesis. Genetic deletion or pharmacological inhibition of\n            <jats:italic toggle=\"yes\">Agt<\/jats:italic>\n            has been demonstrated to be beneficial in a spectrum of diseases experimentally, including hypertension, atherosclerosis, aortic and superior mesenteric artery aneurysms, myocardial dysfunction, and hepatic steatosis. This review summarizes the findings of recent studies utilizing AGT manipulation as a therapeutic approach.\n          <\/jats:p>","DOI":"10.1161\/atvbaha.124.318374","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T09:00:49Z","timestamp":1712221249000},"page":"1021-1030","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Angiotensinogen as a Therapeutic Target for Cardiovascular and Metabolic Diseases"],"prefix":"10.1161","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2093-3775","authenticated-orcid":true,"given":"Alan","family":"Daugherty","sequence":"first","affiliation":[{"name":"Saha Cardiovascular Research Center (A.D., H.S., M.B.S., H.S.L.), University of Kentucky, Lexington."},{"name":"Saha Aortic Center (A.D., H.S., M.B.S., H.S.L.), University of Kentucky, Lexington."},{"name":"Department of Physiology (A.D., H.S., M.B.S., H.S.L.), University of Kentucky, 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