{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:18:51Z","timestamp":1790709531980,"version":"4.1.0"},"reference-count":143,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>Modulating immune function is a critical strategy in cancer and atherosclerosis treatments. For cancer, boosting or maintaining the immune system is crucial to prevent tumor growth. However, in vascular disease, mitigating immune responses can decrease inflammation and slow atherosclerosis progression. Anti-inflammatory therapy, therefore, presents a unique dilemma for cancer survivors: while it may decrease cardiovascular risk, it might also promote cancer growth and metastasis by suppressing the immune response. Senescence presents a potentially targetable solution to this challenge; senescence increases the risk of both cancer therapy resistance and vascular disease. Exercise, notably, shows promise in delaying this premature senescence, potentially improving cancer outcomes and lowering vascular disease risk post-treatment. This review focuses on the long-term impact of cancer therapies on vascular health. We underscore the importance of modulating senescence to balance cancer treatment\u2019s effectiveness and its vascular impact, and we emphasize investigating the role of exercise-mediated suppression of senescence in improving cancer survivorship.<\/jats:p>","DOI":"10.1161\/atvbaha.124.319870","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T10:00:24Z","timestamp":1737021624000},"page":"372-385","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Reevaluating Anti-Inflammatory Therapy: Targeting Senescence to Balance Anti-Cancer Efficacy and Vascular Disease"],"prefix":"10.1161","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3375-3724","authenticated-orcid":true,"given":"Bernardo","family":"Casso-Chapa","sequence":"first","affiliation":[{"name":"Department of Cardiology (B.C.-C., N.A.V.G., N.L.P., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.), The University of Texas MD Anderson Cancer Center, Houston."},{"name":"Instituto Tecnol\u00f3gico y de Estudios Superiores de Monterrey, Escuela de Medicina y Ciencias de la Salud, Nuevo Le\u00f3n, M\u00e9xico (B.C.-C., N.A.V.G., K.C.O.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma Alicia","family":"Vazquez Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Cardiology (B.C.-C., N.A.V.G., N.L.P., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.), The University of Texas MD Anderson Cancer Center, Houston."},{"name":"Instituto Tecnol\u00f3gico y de Estudios Superiores de Monterrey, Escuela de Medicina y Ciencias de la Salud, Nuevo Le\u00f3n, M\u00e9xico (B.C.-C., N.A.V.G., K.C.O.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7746-7328","authenticated-orcid":true,"given":"Nhat-Tu","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Houston Methodist Research Institute, TX (N.-T.L., G.W., K.M.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7565-1797","authenticated-orcid":true,"given":"Nicolas L.","family":"Palaskas","sequence":"additional","affiliation":[{"name":"Department of Cardiology (B.C.-C., N.A.V.G., N.L.P., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9680-8298","authenticated-orcid":true,"given":"Kevin T.","family":"Nead","sequence":"additional","affiliation":[{"name":"Department of Epidemiology (K.T.N.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia P.","family":"Eutsey","sequence":"additional","affiliation":[{"name":"Division of Cancer Center Support Grant &amp; Extramural Research Development (L.P.E.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata S.K.","family":"Samanthapudi","sequence":"additional","affiliation":[{"name":"Department of Cardiology (B.C.-C., N.A.V.G., N.L.P., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail M.","family":"Osborn","sequence":"additional","affiliation":[{"name":"Department of Cardiology (B.C.-C., N.A.V.G., N.L.P., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1182-9653","authenticated-orcid":true,"given":"Jonghae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology (B.C.-C., N.A.V.G., N.L.P., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.), The University of Texas MD Anderson Cancer Center, Houston."},{"name":"Department of Pediatric Research (J.L., K.S.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4048-2013","authenticated-orcid":true,"given":"Gilbert","family":"Mejia","sequence":"additional","affiliation":[{"name":"Department of Cardiology (B.C.-C., N.A.V.G., N.L.P., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5304-585X","authenticated-orcid":true,"given":"Oanh","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Cardiology (B.C.-C., N.A.V.G., N.L.P., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4411-0634","authenticated-orcid":true,"given":"Steven H.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (S.H.L.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6147-9591","authenticated-orcid":true,"given":"Anita","family":"Deswal","sequence":"additional","affiliation":[{"name":"Department of Cardiology (B.C.-C., N.A.V.G., N.L.P., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Division of Preventive Cardiology, Department of Cardiovascular Medicine, Cardio-Oncology Clinic, Mayo Clinic, Rochester, MN (J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4803-7200","authenticated-orcid":true,"given":"Guangyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Houston Methodist Research Institute, TX (N.-T.L., G.W., K.M.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1676-4905","authenticated-orcid":true,"given":"James L.","family":"Kirkland","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Los Angeles, CA (J.L.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1340-4771","authenticated-orcid":true,"given":"Sunil","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The University of Texas Health Science Center at Houston (S. Krishnan)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5044-672X","authenticated-orcid":true,"given":"Xander H.T.","family":"Wehrens","sequence":"additional","affiliation":[{"name":"Departments of Integrative Physiology (X.H.T.W.), Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX."},{"name":"Medicine (X.H.T.W.), Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo N.","family":"Chini","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL (E.N.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6966-6068","authenticated-orcid":true,"given":"Syed Wamique","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Department of Cardiology (B.C.-C., N.A.V.G., N.L.P., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8817-4579","authenticated-orcid":true,"given":"Cezar A.","family":"Iliescu","sequence":"additional","affiliation":[{"name":"Department of Cardiology (B.C.-C., N.A.V.G., N.L.P., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2235-5139","authenticated-orcid":true,"given":"Abhishek","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Texas A&amp;M University, College Station (A.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6173-9074","authenticated-orcid":true,"given":"Jared K.","family":"Burks","sequence":"additional","affiliation":[{"name":"Department of Leukemia, Division of Center Medicine (J.K.B.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8000-5754","authenticated-orcid":true,"given":"Erin","family":"Seeley","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Texas at Austin (E.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0385-7774","authenticated-orcid":true,"given":"Philip L.","family":"Lorenzi","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Computational Biology (P.L.L.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0110-5843","authenticated-orcid":true,"given":"Khanh M.","family":"Chau","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Houston Methodist Research Institute, TX (N.-T.L., G.W., K.M.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7368-4224","authenticated-orcid":true,"given":"Keila C.","family":"Ostos-Mendoza","sequence":"additional","affiliation":[{"name":"Department of Cardiology (B.C.-C., N.A.V.G., N.L.P., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.), The University of Texas MD Anderson Cancer Center, Houston."},{"name":"Instituto Tecnol\u00f3gico y de Estudios Superiores de Monterrey, Escuela de Medicina y Ciencias de la Salud, Nuevo Le\u00f3n, M\u00e9xico (B.C.-C., N.A.V.G., K.C.O.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-3157","authenticated-orcid":true,"given":"Isabella M.","family":"Grumbach","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa (I.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8639-8413","authenticated-orcid":true,"given":"Paul S.","family":"Brookes","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, University of Rochester, NY (P.S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9541-7244","authenticated-orcid":true,"given":"Nordin M.J.","family":"Hanssen","sequence":"additional","affiliation":[{"name":"Department of (Experimental) Vascular and Internal Medicine, Amsterdam University Medical Center, the Netherlands (N.M.J.H.)."},{"name":"Diabeter Centrum Amsterdam, Amsterdam, the Netherlands (N.M.J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4038-6636","authenticated-orcid":true,"given":"Menno P.J.","family":"de Winther","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Atherosclerosis and Ischemic Syndromes, Amsterdam Institute for Immunology and Infectious Diseases, Inflammatory Diseases Amsterdam University Medical Center, University of Amsterdam, the Netherlands (M.P.J.d.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7748-4942","authenticated-orcid":true,"given":"Laurent","family":"Yvan-Charvet","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1065, Universit\u00e9 C\u00f4te d\u2019Azur, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire, F\u00e9d\u00e9ration Hospitalo-Universitaire Oncoage, Institut hospitalo-universitaire RespirERA Respiratory Health, Environment and Ageing, Nice, France (L.Y.-C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7516-7647","authenticated-orcid":true,"given":"Sivareddy","family":"Kotla","sequence":"additional","affiliation":[{"name":"Department of Cardiology (B.C.-C., N.A.V.G., N.L.P., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1675-0514","authenticated-orcid":true,"given":"Keri","family":"Schadler","sequence":"additional","affiliation":[{"name":"Department of Pediatric Research (J.L., K.S.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7439-7774","authenticated-orcid":true,"given":"Jun-ichi","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Cardiology (B.C.-C., N.A.V.G., N.L.P., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.), The University of Texas MD Anderson Cancer Center, Houston."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw211"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21341"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/816897"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.12.1511"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.7907"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-0232"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13030427"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/aac2.12033"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30215-7"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-022-01311-2"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djaa147"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-16-0241"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-024-03108-4"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1534735420917462"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.314617.118"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12170"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e27035"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00416.2017"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000003443"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.861005"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202400137"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-1055"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-023-09798-2"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-47403-2"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-018-4051-4"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-05469-5"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33982"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001022"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-023-00100-w"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP277648"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.01.011"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.04.007"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2024.03.023"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-22-0465"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00520.2010"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02352-6"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-12-0416"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1368550"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6951"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13958"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174306"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.13.300"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.4091"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568009618666171129222159"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23543"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1242\/bio.020362"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21392"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12458"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062329"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5349.349"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm681"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.09.021"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.08.004"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00488-w"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05562-0"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1708"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00314-w"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2466"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(02)02973-3"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells13010039"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1039\/d3ra04527g"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/11.3.298"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.3390\/dna2020010"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1112125"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508886102"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00640"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa132"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-023-10443-0"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2024.02.007"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194959"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032959"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.02.004"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.051923"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqac047"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010027"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00894-x"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1089"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1909"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060301"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e05-07-0672"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04596-6"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E18-10-0650"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102132"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2023.5329"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1212174"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2020.100922"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10787"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2021000270"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038434"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044362"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1701719"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26465"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag1381"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03213-1"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2018.1.264"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013531"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02854-6"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.146076"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djad065"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-00710-0"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014956"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu203"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082155"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155850"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.12.010"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25167"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.322017"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.039"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0249-2"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-2055"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11081178"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.05.048"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.10.035"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.044"},{"key":"e_1_3_3_117_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174154"},{"key":"e_1_3_3_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2009.03.002"},{"key":"e_1_3_3_119_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13294"},{"key":"e_1_3_3_120_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2009.00489.x"},{"key":"e_1_3_3_121_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2010.00583.x"},{"key":"e_1_3_3_122_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx134"},{"key":"e_1_3_3_123_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjcn\/zvab057"},{"key":"e_1_3_3_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.07.037"},{"key":"e_1_3_3_125_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-023-05177-5"},{"key":"e_1_3_3_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2022.07.006"},{"key":"e_1_3_3_127_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34533"},{"key":"e_1_3_3_128_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.635173"},{"key":"e_1_3_3_129_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18935"},{"key":"e_1_3_3_130_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP286269"},{"key":"e_1_3_3_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.12.265"},{"key":"e_1_3_3_132_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00130.2023"},{"key":"e_1_3_3_133_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.816149"},{"key":"e_1_3_3_134_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00429-3"},{"key":"e_1_3_3_135_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP274396"},{"key":"e_1_3_3_136_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23482-5"},{"key":"e_1_3_3_137_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0590-4"},{"key":"e_1_3_3_138_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15245835"},{"key":"e_1_3_3_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30608-9"},{"key":"e_1_3_3_140_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.049981"},{"key":"e_1_3_3_141_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-024-02539-7"},{"key":"e_1_3_3_142_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.582482"},{"key":"e_1_3_3_143_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314649"},{"key":"e_1_3_3_144_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08105-5"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.124.319870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T19:00:52Z","timestamp":1740596452000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.124.319870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":143,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1161\/ATVBAHA.124.319870"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.124.319870","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}