{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:55:09Z","timestamp":1788587709340,"version":"build-2803163510"},"reference-count":83,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Aging is the primary risk factor for atherosclerosis, a degenerative process regulated by immune cells and the leading cause of death worldwide. Previous studies on premature aging syndromes have linked atherosclerosis to defects in A-type lamins, key nuclear envelope components. However, whether these defects influence atherosclerosis during normal aging remains unexplored. Here, we examined how aging affects lamin A\/C expression in circulating leukocytes and investigated the impact of manipulating their expression in hematopoietic cells on their function and atherosclerosis progression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>\n              Flow cytometry assessed lamin A\/C expression in human circulating leukocytes. Bone marrow from donor mice was transplanted into lethally irradiated,\n              <jats:italic toggle=\"yes\">Ldlr<\/jats:italic>\n              <jats:sup>\n                <jats:italic toggle=\"yes\">\u2212\/\u2212<\/jats:italic>\n              <\/jats:sup>\n              -deficient mice to study leukocyte extravasation into the vessel wall via intravital microscopy in the cremaster muscle, and high-fat-diet\u2013induced atherosclerosis via Oil Red O staining of the aorta and carotid arteries. Single-cell RNA sequencing of the aorta was conducted to identify transcriptional changes associated with hematopoietic cell lamin A\/C gain-of-function or loss-of-function.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Human aging is associated with lower levels of lamin A\/C expression in blood-borne leukocytes. To evaluate the functional relationship between hematopoietic lamin A\/C expression and atherosclerosis development, we used\n              <jats:italic toggle=\"yes\">Lmna<\/jats:italic>\n              -null mice and\n              <jats:italic toggle=\"yes\">Lmna<\/jats:italic>\n              <jats:sup>\n                <jats:italic toggle=\"yes\">tg<\/jats:italic>\n              <\/jats:sup>\n              mice, the latter being the first in vivo model of lamin A gain-of-function. Transplanting lamin A\/C\u2013deficient bone marrow into\n              <jats:italic toggle=\"yes\">Ldlr<\/jats:italic>\n              <jats:sup>\n                <jats:italic toggle=\"yes\">\u2212\/\u2212<\/jats:italic>\n              <\/jats:sup>\n              mice increased leukocyte extravasation into the vessel wall and accelerated atherosclerosis. Conversely, transplantation of bone marrow overexpressing lamin A into\n              <jats:italic toggle=\"yes\">Ldlr<\/jats:italic>\n              <jats:sup>\n                <jats:italic toggle=\"yes\">\u2212\/\u2212<\/jats:italic>\n              <\/jats:sup>\n              receptor mice reduced leukocyte extravasation and atherosclerosis. Single-cell RNA sequencing of atherosclerotic mouse aorta revealed that alterations to hematopoietic cell lamin A\/C expression primarily modify the transcriptome of immune cell populations and endothelial cells, affecting their functionality.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>We suggest that the age-related decline in lamin A\/C expression in blood-borne immune cells contributes to increased leukocyte extravasation and atherosclerosis, highlighting lamin A\/C as a novel regulator of age-related atherosclerosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/atvbaha.124.322893","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T05:00:22Z","timestamp":1751518822000},"page":"1616-1635","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Lamin A\/C Expression in Hematopoietic Cells Declines During Human Aging and Constrains Atherosclerosis in Mice"],"prefix":"10.1161","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0025-0731","authenticated-orcid":true,"given":"Marta","family":"Amor\u00f3s-P\u00e9rez","sequence":"first","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.D., F.M.d.B., J.M.G.-G., H.B., J.J.F., V.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6382-9639","authenticated-orcid":true,"given":"Alberto","family":"Del Monte-Monge","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.D., F.M.d.B., J.M.G.-G., H.B., J.J.F., V.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8811-8369","authenticated-orcid":true,"given":"Pilar","family":"Gonzalo","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.D., F.M.d.B., J.M.G.-G., H.B., J.J.F., V.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1202-5478","authenticated-orcid":true,"given":"Mar\u00eda J.","family":"Andr\u00e9s-Manzano","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.D., F.M.d.B., J.M.G.-G., H.B., J.J.F., V.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0572-5620","authenticated-orcid":true,"given":"Cristina","family":"Rius","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.D., F.M.d.B., J.M.G.-G., H.B., J.J.F., V.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4009-4219","authenticated-orcid":true,"given":"V\u00edctor","family":"Fanjul","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.)."},{"name":"Now with Savana Research S.L., Madrid, Spain (V.F.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.D., F.M.d.B., J.M.G.-G., H.B., J.J.F., V.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3345-2555","authenticated-orcid":true,"given":"Cristina","family":"Gonz\u00e1lez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.D., F.M.d.B., J.M.G.-G., H.B., J.J.F., V.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-3874","authenticated-orcid":true,"given":"Guillermo","family":"Moreno","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, Physiotherapy and Podiatry, Nursing Department (G.M.), Department of Immunology, Ophthalmology and ENT, School of Medicine, Universidad Complutense de Madrid."},{"name":"Multidisciplinary Translational Cardiovascular Research Group, Cardiovascular Research Area, Hospital Universitario 12 de Octubre, i+12 Research Institute, Madrid, Spain (G.M., H.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-566X","authenticated-orcid":true,"given":"Alberto","family":"Bengur\u00eda","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4910-1684","authenticated-orcid":true,"given":"Ana","family":"Dopazo","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.D., F.M.d.B., J.M.G.-G., H.B., J.J.F., V.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-1664","authenticated-orcid":true,"given":"F\u00e1tima","family":"S\u00e1nchez-Cabo","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8914-3400","authenticated-orcid":true,"given":"Carlos","family":"Torroja","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1904-5164","authenticated-orcid":true,"given":"Fernando","family":"Mart\u00ednez de Benito","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.D., F.M.d.B., J.M.G.-G., H.B., J.J.F., 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de Recherche (UMR) 144, Paris, France (B.C., P.V.)."},{"name":"Now with Leukomotion Laboratory, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM, UMR-S1151), CNRS UMR-S8253, Institut Necker Enfants Malades, Paris Cit\u00e9 University, France (P.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-7475","authenticated-orcid":true,"given":"Carlos","family":"Silvestre-Roig","sequence":"additional","affiliation":[{"name":"Center for Molecular Biology of Inflammation (ZMBE), Institute of Experimental Pathology, University of M\u00fcnster, Germany (C.S.-R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1177-869X","authenticated-orcid":true,"given":"Jos\u00e9 M.","family":"Gonz\u00e1lez-Granado","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.D., F.M.d.B., J.M.G.-G., H.B., J.J.F., V.A.)."},{"name":"LamImSys Laboratory, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (Imas12), Spain (J.M.G.-G.), Universidad Complutense de Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0277-7596","authenticated-orcid":true,"given":"H\u00e9ctor","family":"Bueno","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.D., F.M.d.B., J.M.G.-G., H.B., J.J.F., V.A.)."},{"name":"Facultad de Medicina (H.B.), Universidad Complutense de Madrid, Spain."},{"name":"Multidisciplinary Translational Cardiovascular Research Group, Cardiovascular Research Area, Hospital Universitario 12 de Octubre, i+12 Research Institute, Madrid, Spain (G.M., H.B.)."},{"name":"Cardiology Department, Hospital Universitario 12 de Octubre and Imas12, Madrid, Spain (H.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5970-629X","authenticated-orcid":true,"given":"Jos\u00e9 J.","family":"Fuster","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.D., F.M.d.B., J.M.G.-G., H.B., J.J.F., V.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0125-7209","authenticated-orcid":true,"given":"Vicente","family":"Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.D., F.M.d.B., J.M.G.-G., H.B., J.J.F., 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of nuclear lamins in nuclear segmentation of human neutrophils.","volume":"31","author":"Yabuki M","year":"1999","unstructured":"Yabuki M, Miyake T, Doi Y, Fujiwara T, Hamazaki K, Yoshioka T, Horton AA, Utsumi K. 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