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Although fibrin may be protective in the early setting of organ injury, persistent fibrin deposition augments inflammatory leukocyte recruitment that propagates tissue damage. Because the timing of fibrin deposition within the transplanted organ influences both damage and repair, the fibrinolytic system plays an essential role in organ recovery after transplantation. Dysfunctional fibrinolysis is linked to adverse outcomes in many diseases but has received less attention in organ transplantation. 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