{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:34:43Z","timestamp":1785285283651,"version":"3.55.0"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The underlying mechanisms of atherosclerosis and strategies for identifying high cardiovascular risk in psoriasis are incompletely understood. Platelet activity is increased in psoriasis and induces vascular dysfunction. We investigated the platelet phenotype and platelet transcriptome as one potential mechanism to explain cardiovascular risk in psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Psoriasis and controls underwent platelet aggregation and activation studies and platelet RNA sequencing to generate a psoriasis platelet transcriptomic score. The relationship between the platelet transcriptomic score and cardiovascular risk was assessed by arterial stiffness, coronary calcium, and longitudinally in an independent cohort of high cardiovascular-risk individuals undergoing lower extremity arterial revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Psoriasis subjects (n=73; median age, 51 years; body surface area of psoriasis, 3%) compared with controls (n=56; median age, 41 years) trended older (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.08) and had greater body mass index (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.01) and higher hs-CRP (high-sensitivity C-reactive protein) values (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.01). Platelet aggregation in response to collagen (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.0049) and ADP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.033), and leukocyte-, neutrophil-, and lymphocyte-platelet aggregates (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05 for each comparison) were all higher in psoriasis versus controls. Platelet RNA sequencing comparing 51 patients with psoriasis with 39 controls identified 329 upregulated and 345 downregulated genes (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05). Pathway analysis identified dysregulated platelet activation, apoptosis, VEGF (vascular endothelial growth factor), interferon, senescence, IL (interleukin)-1, and clotting cascade signaling between psoriasis and controls. Using a phenotypic rank\u2013based scoring methodology, a psoriasis platelet transcriptomic score comprised of 142 genes differentiated psoriasis from controls. This score correlated with arterial stiffness (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      =0.26;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.031) and coronary calcium (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      =0.58;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.0069). In a separate cohort of high cardiovascular-risk patients undergoing lower extremity arterial revascularization, the psoriasis platelet transcriptomic score associated with incident myocardial infarction (adjusted hazard ratio, 3.7 [95% CI, 1.4\u201310.1];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Platelet aggregation and activation are increased in patients with controlled psoriatic disease, with the platelet transcriptome associated with proinflammatory, proatherothrombotic pathways, and cardiovascular risk. Our results warrant further investigation of platelet involvement promoting heightened cardiovascular disease in psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/atvbaha.125.322574","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T09:00:17Z","timestamp":1756976417000},"page":"2086-2096","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Platelet Activation and a Platelet Biosignature Are Associated With Cardiovascular Risk in Patients With Controlled Psoriasis"],"prefix":"10.1161","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6649-3755","authenticated-orcid":true,"given":"Michael S.","family":"Garshick","sequence":"first","affiliation":[{"name":"Department of Medicine, Center for the Prevention of Cardiovascular Disease, Brigham and Women\u2019s Hospital, Boston, MA (M.S.G., J.S.B.)"},{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA (M.S.G., K.D., F.K., E.L.-W., J.S.B.)"},{"name":"Ronald O. Perelman Department of Dermatology, Brigham and Women\u2019s Hospital, Boston, MA (M.S.G., K.L.S., A.N.)"},{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, Cardiovascular Research Center, Brigham and Women\u2019s Hospital, Boston, MA (M.S.G., I.B., M.M., F.S., J.S.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamelia","family":"Drenkova","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA (M.S.G., K.D., F.K., E.L.-W., J.S.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipp","family":"Kazatsker","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA (M.S.G., K.D., F.K., E.L.-W., J.S.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Boothman","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, Cardiovascular Research Center, Brigham and Women\u2019s Hospital, Boston, MA (M.S.G., I.B., M.M., F.S., J.S.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5079-1889","authenticated-orcid":true,"given":"Matthew","family":"Muller","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, Cardiovascular Research Center, Brigham and Women\u2019s Hospital, Boston, MA (M.S.G., I.B., M.M., F.S., J.S.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-6778","authenticated-orcid":true,"given":"Florencia","family":"Schlamp","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, Cardiovascular Research Center, Brigham and Women\u2019s Hospital, Boston, MA (M.S.G., I.B., M.M., F.S., J.S.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4163-2445","authenticated-orcid":true,"given":"Elliot","family":"Luttrell-Williams","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA (M.S.G., K.D., F.K., E.L.-W., J.S.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Lo Sicco","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman Department of Dermatology, Brigham and Women\u2019s Hospital, Boston, MA (M.S.G., K.L.S., A.N.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Neimann","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman Department of Dermatology, Brigham and Women\u2019s Hospital, Boston, MA (M.S.G., K.L.S., A.N.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose U.","family":"Scher","sequence":"additional","affiliation":[{"name":"Psoriatic Arthritis Center, Division of Rheumatology, and NYU Colton Center for Autoimmunity, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA (J.U.S., J.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-2091","authenticated-orcid":true,"given":"Brittany","family":"Weber","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Brigham and Women\u2019s Hospital, Boston, MA (B.W.)."},{"name":"Division of Cardiology, Department of Internal Medicine and Dermatology, University of Texas Southwestern Medical Center, Dallas (B.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3480-2661","authenticated-orcid":true,"given":"Joel M.","family":"Gelfand","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Center for Clinical Sciences and Dermatology, University of Pennsylvania, Philadelphia (J.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3775-1778","authenticated-orcid":true,"given":"James","family":"Krueger","sequence":"additional","affiliation":[{"name":"Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY (J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3852-7129","authenticated-orcid":true,"given":"Jill","family":"Buyon","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA (J.S.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8216-4647","authenticated-orcid":true,"given":"Jeffrey S.","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for the Prevention of Cardiovascular Disease, Brigham and Women\u2019s Hospital, Boston, MA (M.S.G., J.S.B.)"},{"name":"Leon H. 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