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In this review, we provide a comprehensive overview of the versatile roles of hepatic lipase in lipoprotein metabolism, with a focus on the recently discovered\n                    <jats:italic toggle=\"yes\">LIPC<\/jats:italic>\n                    -E97G (point mutation replacing glutamic acid with glycine at position 97) variant. Specifically, we discuss the roles of hepatic lipase in the metabolism of high-density lipoproteins and apoB-containing lipoproteins, as elucidated through in vitro, in vivo, and genetic studies. We also explore the complex interplay between the antiatherogenic and proatherogenic effects of hepatic lipase, highlighting a predominance of antiatherogenic functions for hepatic lipase. 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