{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:19:22Z","timestamp":1790828362387,"version":"4.1.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>CLINICAL PROBLEM:<\/jats:title>\n                    <jats:p>Preeclampsia is a heterogeneous hypertensive disorder of pregnancy characterized by new-onset hypertension and end-organ dysfunction, affecting 5% to 10% of pregnancies globally. It is associated with significant maternal and fetal morbidity and mortality, and delivery remains the only definitive treatment. Understanding the underlying mechanisms is essential for the development of effective therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RECOMMENDATIONS:<\/jats:title>\n                    <jats:p>Given the heterogeneity of preeclampsia and the absence of a single experimental model that fully recapitulates the human disease, the purpose of this review is to evaluate current animal models of preeclampsia according to the pathophysiological mechanisms they represent. We discuss the strengths, limitations, and translational relevance of these models, identify gaps in the existing experimental framework, and highlight opportunities for future model development and therapeutic discovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SUMMARY:<\/jats:title>\n                    <jats:p>Current models reproduce distinct features of preeclampsia, including abnormal placentation, placental ischemia, angiogenic imbalance, endothelial dysfunction, immune activation, and metabolic dysregulation. Despite mechanistic insights, translational success has been limited. Future progress will depend on mechanism-driven model selections, development of models that better capture early placentation defects and disease heterogeneity, multi-hit approaches, including the incorporation of maternal comorbidities, and integration of human-relevant experimental systems to improve clinical translation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/atvbaha.126.322192","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:00:26Z","timestamp":1787767226000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Experimental Animal Models of Preeclampsia: Mechanisms, Strengths, and Translational Relevance"],"prefix":"10.1161","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6606-4133","authenticated-orcid":true,"given":"Jane F.","family":"Reckelhoff","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson (J.F.R., D.C.C., B.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2905-964X","authenticated-orcid":true,"given":"Vladimir","family":"Dokic","sequence":"additional","affiliation":[{"name":"Department of Hypertension and Nephrology (V.D., V.D.G.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6730-6499","authenticated-orcid":true,"given":"Denise C.","family":"Cornelius","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson (J.F.R., D.C.C., B.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3340-6088","authenticated-orcid":true,"given":"Babbette","family":"LaMarca","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson (J.F.R., D.C.C., B.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7636-8256","authenticated-orcid":true,"given":"Styliani","family":"Goulopoulou","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Obstetrics and Gynecology, Loma Linda University, CA (S.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3362-412X","authenticated-orcid":true,"given":"Jessica","family":"Faulkner","sequence":"additional","affiliation":[{"name":"Department of Physiology, Augusta University, GA (J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5360-1243","authenticated-orcid":true,"given":"Jenny L.","family":"Sones","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University College of Veterinary Medicine &amp; Biomedical Sciences, Fort Collins (J.L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3991-8017","authenticated-orcid":true,"given":"Mark","family":"Santillan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Iowa (M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Research Administration (M.L.), Mayo Clinic, Rochester, MN."},{"name":"Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN (M.L., J.W.F., V.D.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6349-3752","authenticated-orcid":true,"given":"Jungwei W.","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Artificial Intelligence and Informatics (J.W.F.), Mayo Clinic, Rochester, MN."},{"name":"Center for Clinical and Translational Science, Mayo 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