{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:54:31Z","timestamp":1790848471272,"version":"4.1.0"},"reference-count":112,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Extracellular vesicles (EVs) moderate a variety of physiological and pathological processes by enabling the intercellular transfer of proteins, nucleic acids, and lipids. Bioactive lipids such as polyunsaturated fatty acids or eicosanoids play an important role in propagation and resolution of inflammation and in vascular regulation. We previously found that the lipid composition of macrophage-derived EVs depends on polarization of the originating macrophages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>In this study, we investigated the role of EV-contained 12-LOX (12-lipoxygenase) metabolites in the moderation of inflammation. We used in vitro functional cell culture models as well as an in vivo sterile peritonitis model with male wild-type mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>We found increased levels of these 12-LOX products in M1 macrophages and M1 macrophage-derived EVs. Inhibition of 12-LOX led to significantly lower levels of 12-LOX metabolites in M1 EVs and attenuated M1 EV-mediated proinflammatory effects such as production of MCP-1 (monocyte chemoattractant protein 1) and CXCL10 (C-X-C motif chemokine ligand 10). M1 EVs induced monocyte adhesion and migration, which were also reduced by 12-LOX inhibition. In a sterile peritonitis model, M1 EVs increased the migration of monocytes into the peritoneum and the presence of macrophages in the peritoneal wall. Both effects were diminished by 12-LOX inhibition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Our results show that the specific lipid profile in macrophage-derived EVs is functionally relevant during inflammation. We demonstrate that eicosanoids in M1 macrophage-derived EVs educate other cells towards a proinflammatory phenotype, promoting inflammation and endothelial dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/atvbaha.126.324954","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:00:18Z","timestamp":1790845218000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Extracellular Vesicle Eicosanoids Mediate Monocyte Migration"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9166-1872","authenticated-orcid":true,"given":"Saikal","family":"Shamkeeva","sequence":"first","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (S.S., S.A., S.J., M.R., Z.L., R.R., A.E., B.I., U.C., M.L.H.), University Leipzig Medical Center, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7960-5181","authenticated-orcid":true,"given":"Saira","family":"Ambreen","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (S.S., S.A., S.J., M.R., Z.L., R.R., A.E., B.I., U.C., M.L.H.), University Leipzig Medical Center, Germany."},{"name":"The Francis Crick Institute, London, United Kingdom (S.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0559-6160","authenticated-orcid":true,"given":"Shihai","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (S.S., S.A., S.J., M.R., Z.L., R.R., A.E., B.I., U.C., M.L.H.), University Leipzig Medical Center, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3864-6424","authenticated-orcid":true,"given":"Madlen","family":"Reinicke","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (S.S., S.A., S.J., M.R., Z.L., R.R., A.E., B.I., U.C., M.L.H.), University Leipzig Medical Center, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8945-3447","authenticated-orcid":true,"given":"Zhiyang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (S.S., S.A., S.J., M.R., Z.L., R.R., A.E., B.I., U.C., M.L.H.), University Leipzig Medical Center, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3178-6347","authenticated-orcid":true,"given":"Rajiv","family":"Rana","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (S.S., S.A., S.J., M.R., Z.L., R.R., A.E., B.I., U.C., M.L.H.), University Leipzig Medical Center, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6784-8370","authenticated-orcid":true,"given":"Ahmed","family":"Elwakiel","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (S.S., S.A., S.J., M.R., Z.L., R.R., A.E., B.I., U.C., M.L.H.), University Leipzig Medical Center, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-7272","authenticated-orcid":true,"given":"Caroline","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Rheumatology Unit (C.S., U.W.), University Leipzig Medical Center, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8106-4924","authenticated-orcid":true,"given":"Ulf","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Rheumatology Unit (C.S., U.W.), University Leipzig Medical Center, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0714-6160","authenticated-orcid":true,"given":"Berend","family":"Isermann","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (S.S., S.A., S.J., M.R., Z.L., R.R., A.E., B.I., U.C., M.L.H.), University Leipzig Medical Center, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4034-5535","authenticated-orcid":true,"given":"Uta","family":"Ceglarek","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (S.S., S.A., S.J., M.R., Z.L., R.R., A.E., B.I., U.C., M.L.H.), University Leipzig Medical Center, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1574-6529","authenticated-orcid":true,"given":"Mitja L.","family":"Heinemann","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (S.S., S.A., S.J., M.R., Z.L., R.R., A.E., B.I., U.C., M.L.H.), University Leipzig Medical Center, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering6010007"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2017.03.001"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2013.04.011"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-018-0854-x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8545347"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-021-00787-y"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R084640"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63772-7.00020-8"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00095-21"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20190083"},{"key":"e_1_3_3_12_2","first-page":"153","volume-title":"Lipids: Categories, Biological Functions and Metabolism, Nutrition and Health","author":"Ahmad MU","year":"2011","unstructured":"Ahmad MU, Ali SM, Ahmad I. Bioactive lipids. In: Stillwell W, ed. Lipids: Categories, Biological Functions and Metabolism, Nutrition and Health. Elsevier; 2011:153\u2013180."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19041227"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.594313"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13241"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3859"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2020.103177"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00530"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2008.08.005"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.10.008"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0665"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam7928"},{"key":"e_1_3_3_23_2","volume-title":"Albert Einstein Healthcare Network\/Einstein Medical Center Montgomery","author":"Hannoodee S","year":"2023","unstructured":"Hannoodee S, Nasuruddin DN. Acute inflammatory response. Albert Einstein Healthcare Network\/Einstein Medical Center Montgomery: StatPearls Publishing, 2023."},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci170733"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2016.163"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802812"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2008.11.004"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17541"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031308"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27010152"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14071319"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.08.014"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2011.06.001"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115252"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01442-3"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2021.100109"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom11050717"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.04.010"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020441"},{"key":"e_1_3_3_41_2","volume-title":"Probe Reports from the NIH Molecular Libraries Program","author":"Luci D","year":"2013","unstructured":"Luci D, Jameson JB II, Yasgar A, et al. Probe Reports from the NIH Molecular Libraries Program. National Center for Biotechnology Information (US); 2010; 2013."},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.08.001"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309868"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2014.10.026"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7253-1_4"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1039\/c0fo00113a"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2016.01.012"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep14273"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2fo30156c"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173090"},{"key":"e_1_3_3_51_2","unstructured":"GmbH PM. Operating instructions for ZetaView\u00ae Nanoparticle Tracking Analyzers PMX-120 PMX-220 PMX-420. 2021"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-019-02170-w"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-006-0097-6"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4189"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.3390\/md13074156"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-3052-5_22"},{"key":"e_1_3_3_57_2","first-page":"1","article-title":"Vybrant cell-labeling solutions.","author":"Probes M","year":"2001","unstructured":"Probes M. Vybrant cell-labeling solutions. Solutions. 2001;1\u20133.","journal-title":"Solutions"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im0701s85"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1089\/bio.2015.0104"},{"key":"e_1_3_3_60_2","article-title":"No Title.","author":"Anon","year":"2024","unstructured":"Anon. No Title. Image J Docs. 2024.","journal-title":"Image J Docs"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1177\/2211068214561025"},{"key":"e_1_3_3_62_2","first-page":"1113","article-title":"Effect of diet and sex on the relative lipid composition of plasma and red blood cells in the rat.","volume":"11","author":"Monsen ER","year":"1962","unstructured":"Monsen ER, Okey R, Lyman RL. Effect of diet and sex on the relative lipid composition of plasma and red blood cells in the rat. Metab Clin Exp. 1962;11:1113\u20131124.","journal-title":"Metab Clin Exp"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.136.suppl_1.19156"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.06.128"},{"key":"e_1_3_3_65_2","first-page":"239","volume-title":"Tumor Immunology and Immunotherapy\u2014Cellular Methods Part A","author":"Terr\u00e9n I","year":"2020","unstructured":"Terr\u00e9n I, Orrantia A, Vitall\u00e9 J, Zenarruzabeitia O, Borrego F. Chapter twelve\u2014CFSE dilution to study human T and NK cell proliferation in vitro. In: Galluzzi L, Rudqvist N-P, eds. Tumor Immunology and Immunotherapy\u2014Cellular Methods Part A. Vol 631. Academic Press; 2020:239\u2013255."},{"key":"e_1_3_3_66_2","unstructured":"Gnjatic S. Olink analytical validation Mt Sinai CIMAC. 2018"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b05979"},{"key":"e_1_3_3_68_2","first-page":"1929","article-title":"A new, simple, nonradioactive, nontoxic in vitro assay to monitor corneal endothelial cell viability.","volume":"38","author":"Larson EM","year":"1997","unstructured":"Larson EM, Doughman DJ, Gregerson DS, Obritsch WF. A new, simple, nonradioactive, nontoxic in vitro assay to monitor corneal endothelial cell viability. Invest Ophthalmol Vis Sci. 1997;38:1929\u20131933.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2014.09.014"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.add8913"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17749-6"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2021.102403"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04640-z"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.715461"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159724"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01167"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-021-00622-5"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11020106"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12803"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2013.10.004"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11496-3"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14108"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2017.01.034"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06095-8"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1177\/2042018810375656"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-018-9731-3"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.03.020"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69831-0"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.71.2.173"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/893106"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.705852"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m300856200"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)46220-X"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(88)90318-9"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933430"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2005.09.003"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(89)90098-1"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109270"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2012.07.004"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1177\/2042018818759894"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.121.000973"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S180334"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201500076"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20180635"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1480-9"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.315154"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.03.012"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4451"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI136621"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1089\/bio.2015.0005"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603484200"},{"key":"e_1_3_3_112_2","author":"Toews GB","year":"2008","unstructured":"Toews GB, Macrophages. 2008.","journal-title":"Macrophages"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0710409"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.126.324954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:00:25Z","timestamp":1790845225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.126.324954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":112,"alternative-id":["10.1161\/ATVBAHA.126.324954"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.126.324954","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"2026-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ATVBAHA.126.324954"}}