{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:46:22Z","timestamp":1792057582716,"version":"4.4.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"abstract":"\n BACKGROUND:<\/jats:title>\n Chronic thromboembolic pulmonary hypertension (CTEPH) has traditionally been considered a long-term complication of pulmonary embolism. However, a substantial proportion of patients have no history of venous thromboembolism (VTE), suggesting underlying biological heterogeneity.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n We analyzed clinical and imaging characteristics of 712 patients with CTEPH stratified by prior VTE history. Whole-genome sequencing was performed in all patients and 2952 healthy controls to assess common variants. Bulk RNA sequencing of pulmonary endarterectomy tissues and plasma protein quantification were integrated to identify and validate subgroup-specific molecular signatures, with further validation in tissue and primary endothelial cells.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Patients with CTEPH and prior VTE (n=576, 80.9%) exhibited a distinct thrombotic phenotype with more proximal disease distribution (92.5% versus 66.2%) and greater likelihood of undergoing pulmonary endarterectomy (22.6% versus 3.7%). Genome-wide association study in CTEPH-VTE(+) patients versus controls identified coagulation-related loci at\n ABO<\/jats:italic>\n (rs676996,\n P<\/jats:italic>\n =1.1\u00d710\n \u20139<\/jats:sup>\n ) and\n FGG<\/jats:italic>\n (rs7681423,\n P<\/jats:italic>\n =2.5\u00d710\n \u20138<\/jats:sup>\n ), with high genetic correlation with pulmonary embolism (rg=0.52,\n P<\/jats:italic>\n =0.028). In contrast, no consistent genomic signal was identified in patients without prior VTE. Integrative multiomics (transcriptome-wide association study, MAGMA, and bulk RNA sequencing differential expression analysis) convergently prioritized\n CTSS<\/jats:italic>\n (cathepsin S) as a key molecular candidate in CTEPH-VTE(+). CTSS was consistently elevated in plasma, pulmonary endarterectomy tissue, and primary endothelial cells from CTEPH-VTE(+) patients and promoted endothelial proliferation via ERK signaling, which was attenuated by the selective\n CTSS<\/jats:italic>\n inhibitor LY3000328.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n Stratification by prior VTE history reveals biologically distinct CTEPH phenotypes with divergent genetic architectures and identifies cathepsin S as a genetically nominated therapeutic target for thrombosis-associated pulmonary vascular remodeling.<\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/atvbaha.126.325037","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:00:26Z","timestamp":1792054826000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Prior Venous Thromboembolism Defines Distinct Genetic and Molecular Phenotypes in Chronic Thromboembolic Pulmonary Hypertension"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7602-096X","authenticated-orcid":true,"given":"Zhu","family":"Zhang","sequence":"first","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5351-7470","authenticated-orcid":true,"given":"Mengjie","family":"Duo","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."},{"name":"China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China (M.D., X.J., B.Z., Haobo Li, K.L., Yuhan Li)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Ji","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."},{"name":"China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China (M.D., X.J., B.Z., Haobo Li, K.L., Yuhan Li)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5998-4689","authenticated-orcid":true,"given":"Bingzhang","family":"Zou","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."},{"name":"China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China (M.D., X.J., B.Z., Haobo Li, K.L., Yuhan Li)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1882-5831","authenticated-orcid":true,"given":"Haobo","family":"Li","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."},{"name":"China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China (M.D., X.J., B.Z., Haobo Li, K.L., Yuhan Li)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6987-6527","authenticated-orcid":true,"given":"Kuangxun","family":"Li","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."},{"name":"China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China (M.D., X.J., B.Z., Haobo Li, K.L., Yuhan Li)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwen","family":"Li","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."},{"name":"Department of Pulmonary and Critical Care Medicine, Second Affiliated Hospital of Harbin Medical University, China (Huiwen Li)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Li","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."},{"name":"China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China (M.D., X.J., B.Z., Haobo Li, K.L., Yuhan Li)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishan","family":"Li","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7774-5236","authenticated-orcid":true,"given":"Xincheng","family":"Li","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixiang","family":"Liu","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5053-5589","authenticated-orcid":true,"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2614-6384","authenticated-orcid":true,"given":"Wenxin","family":"Duan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Health and Multimorbidity, Department of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China (W.D., P.Y.)."},{"name":"National Center for Respiratory Medicine, Beijing, China (W.D., P.Y.)."},{"name":"Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China (W.D., P.Y.)."},{"name":"National Clinical Research Center for Respiratory Diseases, Beijing, China (W.D., P.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Lu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou Medical University, China (J. Lu, Huizhao Liao, C.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhao","family":"Liao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou Medical University, China (J. Lu, Huizhao Liao, C.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2464-5239","authenticated-orcid":true,"given":"Ran","family":"Miao","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, National Center for Respiratory Medicine Labs, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China (R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4635-1215","authenticated-orcid":true,"given":"Peiran","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Health and Multimorbidity, Department of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China (W.D., P.Y.)."},{"name":"National Center for Respiratory Medicine, Beijing, China (W.D., P.Y.)."},{"name":"Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China (W.D., P.Y.)."},{"name":"National Clinical Research Center for Respiratory Diseases, Beijing, China (W.D., P.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3247-5847","authenticated-orcid":true,"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9505-8608","authenticated-orcid":true,"given":"Athiththan","family":"Yogeswaran","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University Giessen, Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Germany (A.Y.)."},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, Germany (A.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0650-1351","authenticated-orcid":true,"given":"Ruifang","family":"Li-Gao","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, the Netherlands (R.L.-G., A.v.H.V., S.C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7386-1168","authenticated-orcid":true,"given":"Astrid","family":"van Hylckama Vlieg","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, the Netherlands (R.L.-G., A.v.H.V., S.C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9961-0754","authenticated-orcid":true,"given":"Frederikus A.","family":"Klok","sequence":"additional","affiliation":[{"name":"Department of Medicine, Thrombosis and Hemostasis, Leiden University Medical Center, the Netherlands (F.A.K., S.C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4707-2303","authenticated-orcid":true,"given":"Suzanne C.","family":"Cannegieter","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, the Netherlands (R.L.-G., A.v.H.V., S.C.C.)."},{"name":"Department of Medicine, Thrombosis and Hemostasis, Leiden University Medical Center, the Netherlands (F.A.K., S.C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1177-5568","authenticated-orcid":true,"given":"Lan","family":"Zhao","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute (NHLI), Imperial College London, Hammersmith Hospital, United Kingdom (L.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanmu","family":"Xie","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."},{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Integrative Pulmonary Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China (W.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Hong","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou Medical University, China (J. Lu, Huizhao Liao, C.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7096-8792","authenticated-orcid":true,"given":"Zhenguo","family":"Zhai","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7857-5435","authenticated-orcid":true,"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (Z. Zhang, M.D., X.J., B.Z., Haobo Li, K.L., Huiwen Li, Yuhan Li, Yishan Li, X.L., J. Liu, Y.Z., S.Z., W.X., Z. Zhai, C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(23)00292-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.01010-2023"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01562-2025"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01792-2016"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00449-2023"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac206"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016522"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2024.09.006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.00001115"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.313658"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201509-620AS"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12010046"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-021-01572-6"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01805-2018"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00589-2018"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2025.02.033"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.03.029"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.10.004"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202307-1236OC"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacasi.2022.02.010"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-024-03042-5"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30841-9"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-02844-4"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202402-0471ED"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00530.2018"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.122.318455"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-023-01040-4"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70003"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2010.157"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41435-021-00156-2"}],"container-title":["Arteriosclerosis, Thrombosis, and Vascular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/ATVBAHA.126.325037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:00:27Z","timestamp":1792054827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.126.325037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":30,"alternative-id":["10.1161\/ATVBAHA.126.325037"],"URL":"https:\/\/doi.org\/10.1161\/atvbaha.126.325037","relation":{},"ISSN":["1079-5642","1524-4636"],"issn-type":[{"value":"1079-5642","type":"print"},{"value":"1524-4636","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]},"assertion":[{"value":"2026-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ATVBAHA.126.325037"}}