{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:04:51Z","timestamp":1791104691611,"version":"4.1.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            We investigated the benefits of the more physiological activation achieved by left ventricular (LV) endocardial pacing (ENDO) as compared with conventional epicardial (EPI) LV pacing in cardiac resynchronization therapy.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            In 8 anesthetized dogs with experimental left bundle-branch block, pacing leads were positioned in the right atrium, right ventricle, and at 8 paired (EPI and ENDO) LV sites. Systolic LV pump function was assessed as LVdP\/dtmax and stroke work and diastolic function as LVdP\/dtmin. Electrical activation and dispersion of repolarization were determined from 122 epicardial and endocardial electrodes and from analysis of the surface ECG. Overall, ENDO-biventricular (BiV) pacing more than doubled the degree of electrical resynchronization and increased the benefit on LVdP\/dtmax and stroke work by 90% and 50%, respectively, as compared with EPI-BiV pacing. During single-site LV pacing, the range of AV intervals with a &gt;10% increase in LV resynchronization (79\ufffd31 versus 32\ufffd24 ms,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) and LVdP\/dtmax (92\ufffd29 versus 63\ufffd39 ms) was significantly longer for ENDO than for EPI pacing. EPI-BiV but not ENDO-BiV pacing created a significant (40\ufffd21 ms) transmural dispersion of repolarization.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Data from this acute animal study indicate that the use of an endocardial LV pacing electrode may increase the efficacy of resynchronization therapy as compared with conventional epicardial resynchronization therapy.\n          <\/jats:p>","DOI":"10.1161\/circep.108.846022","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T01:47:22Z","timestamp":1249955242000},"page":"580-587","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":109,"title":["Left Ventricular Endocardial Pacing Improves Resynchronization Therapy in Canine Left Bundle-Branch Hearts"],"prefix":"10.1161","volume":"2","author":[{"given":"Caroline","family":"van Deursen","sequence":"first","affiliation":[{"name":"From the Departments of Physiology and Cardiothoracic Surgery (C.v.D., I.E.v.G., L.M.R., A.H., M.K., F.W.P.), Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; Biometry and Clinical Epidemiology (C.K.), Research Department, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy; and Fondazione Cardiocentro Ticino (A.A.), Lugano, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene E.","family":"van Geldorp","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology and Cardiothoracic Surgery (C.v.D., I.E.v.G., L.M.R., A.H., M.K., F.W.P.), Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; Biometry and Clinical Epidemiology (C.K.), Research Department, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy; and Fondazione Cardiocentro Ticino (A.A.), Lugano, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard M.","family":"Rademakers","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology and Cardiothoracic Surgery (C.v.D., I.E.v.G., L.M.R., A.H., M.K., F.W.P.), Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; Biometry and Clinical Epidemiology (C.K.), Research Department, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy; and Fondazione Cardiocentro Ticino (A.A.), Lugano, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"van Hunnik","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology and Cardiothoracic Surgery (C.v.D., I.E.v.G., L.M.R., A.H., M.K., F.W.P.), Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; Biometry and Clinical Epidemiology (C.K.), Research Department, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy; and Fondazione Cardiocentro Ticino (A.A.), Lugano, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Kuiper","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology and Cardiothoracic Surgery (C.v.D., I.E.v.G., L.M.R., A.H., M.K., F.W.P.), Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; Biometry and Clinical Epidemiology (C.K.), Research Department, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy; and Fondazione Cardiocentro Ticino (A.A.), Lugano, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Klersy","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology and Cardiothoracic Surgery (C.v.D., I.E.v.G., L.M.R., A.H., M.K., F.W.P.), Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; Biometry and Clinical Epidemiology (C.K.), Research Department, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy; and Fondazione Cardiocentro Ticino (A.A.), Lugano, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Auricchio","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology and Cardiothoracic Surgery (C.v.D., I.E.v.G., L.M.R., A.H., M.K., F.W.P.), Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; Biometry and Clinical Epidemiology (C.K.), Research Department, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy; and Fondazione Cardiocentro Ticino (A.A.), Lugano, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits W.","family":"Prinzen","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology and Cardiothoracic Surgery (C.v.D., I.E.v.G., L.M.R., A.H., M.K., F.W.P.), Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; Biometry and Clinical Epidemiology (C.K.), Research Department, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy; and Fondazione Cardiocentro Ticino (A.A.), Lugano, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.63.1.3383372"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.035"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00641-7"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi008"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00641.2005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm207"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.09.007"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.11.022"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.64.3.2917378"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.30.2.217"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.42.1.338194"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1998.tb01163.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00091-3"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2000.tb07010.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.11.023"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01892-6"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.03.052"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000118502.91105.f6"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.081"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.03.008"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000068376.88600.41"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.688317"}],"container-title":["Circulation: Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.108.846022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:50:04Z","timestamp":1715557804000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.108.846022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1161\/CIRCEP.108.846022"],"URL":"https:\/\/doi.org\/10.1161\/circep.108.846022","relation":{},"ISSN":["1941-3149","1941-3084"],"issn-type":[{"value":"1941-3149","type":"print"},{"value":"1941-3084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"2009-08-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}