{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:41:08Z","timestamp":1784004068005,"version":"3.55.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Termination of persistent atrial fibrillation (AF) can be achieved through ablation, with the majority of patients terminating to an atrial  tachycardia (AT) and fewer directly to sinus rhythm (SR). We aimed to identify potential predictors for the existence of a substrate for AT on termination to SR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We assessed 95 persistent AF patients (age, 60\u00b110 years) who underwent catheter ablation to the end point of AF termination. Forty patients terminated directly to SR (SRterm) and 55 to ATs (ATterm). Compared with the ATterm group, the SRterm group were younger (56\u00b110 versus 63\u00b19 years,\n              <jats:italic>P<\/jats:italic>\n              =0.001), had shorter durations of AF before ablation (9\u00b126 versus 14\u00b120 months,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), smaller left atrial diameters (41\u00b15 versus 45\u00b15 mm,\n              <jats:italic>P<\/jats:italic>\n              =0.015), and longer baseline AF cycle lengths (178\u00b123 versus 159\u00b131 ms,\n              <jats:italic>P<\/jats:italic>\n              =0.005). However, AF cycle length was the sole independent predictor of direct termination to SR. The most frequent AF termination site in SRterm patients was the pulmonary veins (53%), whereas in ATterm patients this was within the left atrium (58%). After follow-up of 12\u00b16 months, there was a trend toward a greater proportion of patients in SR among those who terminated directly to SR after a single procedure. The most frequent type of recurrence was paroxysmal AF in SRterm patients and AT in ATterm patients.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Patients who terminate to SR through ablation without an intermediate AT are characterized by a less altered arrhythmogenic substrate. Baseline AF cycle lengths emerged as a sole independent predictor of a substrate for consecutive arrhythmias.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.110.945279","type":"journal-article","created":{"date-parts":[[2010,5,29]],"date-time":"2010-05-29T03:46:07Z","timestamp":1275104767000},"page":"351-360","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Atrial Fibrillation Cycle Length Is a Sole Independent Predictor of a Substrate for Consecutive Arrhythmias in Patients With Persistent Atrial Fibrillation"],"prefix":"10.1161","volume":"3","author":[{"given":"Imke","family":"Drewitz","sequence":"first","affiliation":[{"name":"From the Department of Electrophysiology (I.D., S.W., T.V.S., D.S., B.A.F., H.S., K.B., M.A.A., T.M., T.R.), University Heart Center, and the Department of Medical Biometry and Epidemiology (K.W.) University Hospital Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Willems","sequence":"additional","affiliation":[{"name":"From the Department of Electrophysiology (I.D., S.W., T.V.S., D.S., B.A.F., H.S., K.B., M.A.A., T.M., T.R.), University Heart Center, and the Department of Medical Biometry and Epidemiology (K.W.) University Hospital Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar V.","family":"Salukhe","sequence":"additional","affiliation":[{"name":"From the Department of Electrophysiology (I.D., S.W., T.V.S., D.S., B.A.F., H.S., K.B., M.A.A., T.M., T.R.), University Heart Center, and the Department of Medical Biometry and Epidemiology (K.W.) University Hospital Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Steven","sequence":"additional","affiliation":[{"name":"From the Department of Electrophysiology (I.D., S.W., T.V.S., D.S., B.A.F., H.S., K.B., M.A.A., T.M., T.R.), University Heart Center, and the Department of Medical Biometry and Epidemiology (K.W.) University Hospital Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris A.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"From the Department of Electrophysiology (I.D., S.W., T.V.S., D.S., B.A.F., H.S., K.B., M.A.A., T.M., T.R.), University Heart Center, and the Department of Medical Biometry and Epidemiology (K.W.) University Hospital Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"Servatius","sequence":"additional","affiliation":[{"name":"From the Department of Electrophysiology (I.D., S.W., T.V.S., D.S., B.A.F., H.S., K.B., M.A.A., T.M., T.R.), University Heart Center, and the Department of Medical Biometry and Epidemiology (K.W.) University Hospital Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Bock","sequence":"additional","affiliation":[{"name":"From the Department of Electrophysiology (I.D., S.W., T.V.S., D.S., B.A.F., H.S., K.B., M.A.A., T.M., T.R.), University Heart Center, and the Department of Medical Biometry and Epidemiology (K.W.) University Hospital Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammet Ali","family":"Aydin","sequence":"additional","affiliation":[{"name":"From the Department of Electrophysiology (I.D., S.W., T.V.S., D.S., B.A.F., H.S., K.B., M.A.A., T.M., T.R.), University Heart Center, and the Department of Medical Biometry and Epidemiology (K.W.) University Hospital Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Wegscheider","sequence":"additional","affiliation":[{"name":"From the Department of Electrophysiology (I.D., S.W., T.V.S., D.S., B.A.F., H.S., K.B., M.A.A., T.M., T.R.), University Heart Center, and the Department of Medical Biometry and Epidemiology (K.W.) 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