{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:52:07Z","timestamp":1792684327778,"version":"4.5.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Atrial fibrillation (AF) has been linked to inflammatory factors and obesity. Epicardial fat is a source of several inflammatory mediators related to the development of coronary artery disease. We hypothesized that periatrial fat may have a similar role in the development of AF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Left atrium (LA) epicardial fat pad thickness was measured in consecutive cardiac CT angiograms performed for coronary artery disease or AF. Patients were grouped by AF burden: no (n=73), paroxysmal (n=60), or persistent (n=36) AF. In a short-axis view at the mid LA, periatrial epicardial fat thickness was measured at the esophagus (LA-ESO), main pulmonary artery, and thoracic aorta; retrosternal fat was measured in axial view (right coronary ostium level). LA area was determined in the 4-chamber view. LA-ESO fat was thicker in patients with persistent AF versus paroxysmal AF (\n              <jats:italic>P<\/jats:italic>\n              =0.011) or no AF (\n              <jats:italic>P<\/jats:italic>\n              =0.003). LA area was larger in patients with persistent AF than paroxysmal AF (\n              <jats:italic>P<\/jats:italic>\n              =0.004) or without AF (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). LA-ESO was a significant predictor of AF burden even after adjusting for age, body mass index, and LA area (odds ratio, 5.30; 95% confidence interval, 1.39 to 20.24;\n              <jats:italic>P<\/jats:italic>\n              =0.015). A propensity score\u2013adjusted multivariable logistic regression that included age, body mass index, LA area, and comorbidities was also performed and the relationship remained statistically significant (\n              <jats:italic>P<\/jats:italic>\n              =0.008).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Increased posterior LA fat thickness appears to be associated with AF burden independent of age, body mass index, or LA area. Further studies are necessary to examine cause and effect, and if inflammatory, paracrine mediators explain this association.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.110.957241","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T02:15:56Z","timestamp":1274926556000},"page":"230-236","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":209,"title":["Left Atrial Epicardial Adiposity and Atrial Fibrillation"],"prefix":"10.1161","volume":"3","author":[{"given":"Omar","family":"Batal","sequence":"first","affiliation":[{"name":"From the Departments of General Internal Medicine (O.B., A.E.A.), Cardiovascular Medicine (P.S., M.S., D.V.W., P.T., M.C.), and Diagnostic Radiology (P.S., S.H.), the Cleveland Clinic, Cleveland, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Schoenhagen","sequence":"additional","affiliation":[{"name":"From the Departments of General Internal Medicine (O.B., A.E.A.), Cardiovascular Medicine (P.S., M.S., D.V.W., P.T., M.C.), and Diagnostic Radiology (P.S., S.H.), the Cleveland Clinic, Cleveland, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyuan","family":"Shao","sequence":"additional","affiliation":[{"name":"From the Departments of General Internal Medicine (O.B., A.E.A.), Cardiovascular Medicine (P.S., M.S., D.V.W., P.T., M.C.), and Diagnostic Radiology (P.S., S.H.), the Cleveland Clinic, Cleveland, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala Eddin","family":"Ayyad","sequence":"additional","affiliation":[{"name":"From the Departments of General Internal Medicine (O.B., A.E.A.), Cardiovascular Medicine (P.S., M.S., D.V.W., P.T., M.C.), and Diagnostic Radiology (P.S., S.H.), the Cleveland Clinic, Cleveland, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Van Wagoner","sequence":"additional","affiliation":[{"name":"From the Departments of General Internal Medicine (O.B., A.E.A.), Cardiovascular Medicine (P.S., M.S., D.V.W., P.T., M.C.), and Diagnostic Radiology (P.S., S.H.), the Cleveland Clinic, Cleveland, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra S.","family":"Halliburton","sequence":"additional","affiliation":[{"name":"From the Departments of General Internal Medicine (O.B., A.E.A.), Cardiovascular Medicine (P.S., M.S., D.V.W., P.T., M.C.), and Diagnostic Radiology (P.S., S.H.), the Cleveland Clinic, Cleveland, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Tchou","sequence":"additional","affiliation":[{"name":"From the Departments of General Internal Medicine (O.B., A.E.A.), Cardiovascular Medicine (P.S., M.S., D.V.W., P.T., M.C.), and Diagnostic Radiology (P.S., S.H.), the Cleveland Clinic, Cleveland, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina K.","family":"Chung","sequence":"additional","affiliation":[{"name":"From the Departments of General Internal Medicine (O.B., A.E.A.), Cardiovascular Medicine (P.S., M.S., D.V.W., P.T., M.C.), and Diagnostic Radiology (P.S., S.H.), the Cleveland Clinic, Cleveland, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.18.2370"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198204293061703"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03260270025020"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90613-Z"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.10.3542"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-004-0800-x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.11.032"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4901.101760"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000103131.70301.4F"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.4.1180"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(03)00405-5"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00709-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.743062"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.71.536"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm564"},{"key":"e_1_3_2_17_2","article-title":"Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study","author":"Mahabadi AA","year":"2009","unstructured":"Mahabadi AA, Massaro JM, Rosito GA, Levy D, Murabito JM, Wolf PA, O'Donnell CJ, Fox CS, Hoffmann U. Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study. Eur Heart J. 2009 [Epub ahead of print].","journal-title":"Eur Heart J"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.20.2471"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.10.005"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.167586"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.177031"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.182998"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.107.159228"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000099542.57313.C5"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809033391003"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000149714.31471.FD"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.551291"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70187-X"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(97)70242-3"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(02)00259-2"},{"key":"e_1_3_2_31_2","article-title":"Meta-analysis of randomized trials on the efficacy of posterior pericardiotomy in preventing atrial fibrillation after coronary artery bypass surgery","author":"Biancari F","year":"2009","unstructured":"Biancari F, Asim Mahar MA. Meta-analysis of randomized trials on the efficacy of posterior pericardiotomy in preventing atrial fibrillation after coronary artery bypass surgery. J Thorac Cardiovasc Surg. 2009 [Epub ahead of print].","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.033"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.02.020"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.08.040"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.08.023"}],"container-title":["Circulation: Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.110.957241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:18:44Z","timestamp":1715559524000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.110.957241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1161\/CIRCEP.110.957241"],"URL":"https:\/\/doi.org\/10.1161\/circep.110.957241","relation":{},"ISSN":["1941-3149","1941-3084"],"issn-type":[{"value":"1941-3149","type":"print"},{"value":"1941-3084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"2009-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-04-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}