{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:25:46Z","timestamp":1775060746136,"version":"3.50.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>In animal models of atrial fibrillation (AF), changes in atrial electrophysiological properties are associated with the development of AF. Their relevance to human AF is unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              The Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial enrolled 2580 patients receiving a dual-chamber pacemaker, who were older than the age of 65 and had a history of hypertension, but no history of AF. Serial noninvasive electrophysiological testing was performed over 2 years in a subgroup of 485 patients. There were no differences in the clinical characteristics between patients with and those without device-detected atrial tachyarrhythmias during the first year. Patients with atrial tachyarrhythmias had longer paced (153\u00b129 versus 145\u00b128 ms;\n              <jats:italic>P<\/jats:italic>\n              =0.046) and sensed (128\u00b146 versus 118\u00b125 ms;\n              <jats:italic>P<\/jats:italic>\n              =0.06) P-wave durations and were more likely to have AF induced during electrophysiological testing (23.5% versus 13.6%;\n              <jats:italic>P<\/jats:italic>\n              =0.03). They had similar corrected sinus node recovery times at 90 bpm (388\u00b1554 versus 376 \u00b1 466 ms;\n              <jats:italic>P<\/jats:italic>\n              =0.86), atrial effective refractory periods at 90 bpm (250\u00b132 versus 248\u00b136 ms;\n              <jats:italic>P<\/jats:italic>\n              =0.70), and rate-adaptive shortening of the atrial effective refractory periods (14\u00b113 versus 12\u00b114 ms;\n              <jats:italic>P<\/jats:italic>\n              =0.11). There were no significant differences in the change in electrophysiological properties over 2 years between patients with and those without atrial tachyarrhythmias.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Prolonged P-wave duration, but not differences in atrial effective refractory periods, was associated with the development of atrial tachyarrhythmias in pacemaker patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.112.970442","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T02:15:09Z","timestamp":1338948909000},"page":"626-631","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Relevance of Electrical Remodeling in Human Atrial Fibrillation"],"prefix":"10.1161","volume":"5","author":[{"given":"Jeff S.","family":"Healey","sequence":"first","affiliation":[{"name":"From the Population Health Research Institute, McMaster University, Hamilton, Canada (J.S.H., S.J.C., G.M.N., S.D., E.T., C.A.M.); Evangelisches Krankenhaus Bielefeld, Bielefeld (C.W.I.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); Clinica di Cardiologia, Universit\u00e0 Politecnica delle Marche, Ancona, Italy (A.C.); University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (I.C.V.G.); University of Hong Kong, Queen Mary Hospital, Hong Kong, China (C.-P.L.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten W.","family":"Israel","sequence":"additional","affiliation":[{"name":"From the Population Health Research Institute, McMaster University, Hamilton, Canada (J.S.H., S.J.C., G.M.N., S.D., E.T., C.A.M.); Evangelisches Krankenhaus Bielefeld, Bielefeld (C.W.I.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); Clinica di Cardiologia, Universit\u00e0 Politecnica delle Marche, Ancona, Italy (A.C.); University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (I.C.V.G.); University of Hong Kong, Queen Mary Hospital, Hong Kong, China (C.-P.L.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart J.","family":"Connolly","sequence":"additional","affiliation":[{"name":"From the Population Health Research Institute, McMaster University, Hamilton, Canada (J.S.H., S.J.C., G.M.N., S.D., E.T., C.A.M.); Evangelisches Krankenhaus Bielefeld, Bielefeld (C.W.I.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); Clinica di Cardiologia, Universit\u00e0 Politecnica delle Marche, Ancona, Italy (A.C.); University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (I.C.V.G.); University of Hong Kong, Queen Mary Hospital, Hong Kong, China (C.-P.L.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan H.","family":"Hohnloser","sequence":"additional","affiliation":[{"name":"From the Population Health Research Institute, McMaster University, Hamilton, Canada (J.S.H., S.J.C., G.M.N., S.D., E.T., C.A.M.); Evangelisches Krankenhaus Bielefeld, Bielefeld (C.W.I.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); Clinica di Cardiologia, Universit\u00e0 Politecnica delle Marche, Ancona, Italy (A.C.); University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (I.C.V.G.); University of Hong Kong, Queen Mary Hospital, Hong Kong, China (C.-P.L.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girish M.","family":"Nair","sequence":"additional","affiliation":[{"name":"From the Population Health Research Institute, McMaster University, Hamilton, Canada (J.S.H., S.J.C., G.M.N., S.D., E.T., C.A.M.); Evangelisches Krankenhaus Bielefeld, Bielefeld (C.W.I.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); Clinica di Cardiologia, Universit\u00e0 Politecnica delle Marche, Ancona, Italy (A.C.); University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (I.C.V.G.); University of Hong Kong, Queen Mary Hospital, Hong Kong, China (C.-P.L.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syamkumar","family":"Divakaramenon","sequence":"additional","affiliation":[{"name":"From the Population Health Research Institute, McMaster University, Hamilton, Canada (J.S.H., S.J.C., G.M.N., S.D., E.T., C.A.M.); Evangelisches Krankenhaus Bielefeld, Bielefeld (C.W.I.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); Clinica di Cardiologia, Universit\u00e0 Politecnica delle Marche, Ancona, Italy (A.C.); University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (I.C.V.G.); University of Hong Kong, Queen Mary Hospital, Hong Kong, China (C.-P.L.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Capucci","sequence":"additional","affiliation":[{"name":"From the Population Health Research Institute, McMaster University, Hamilton, Canada (J.S.H., S.J.C., G.M.N., S.D., E.T., C.A.M.); Evangelisches Krankenhaus Bielefeld, Bielefeld (C.W.I.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); Clinica di Cardiologia, Universit\u00e0 Politecnica delle Marche, Ancona, Italy (A.C.); University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (I.C.V.G.); University of Hong Kong, Queen Mary Hospital, Hong Kong, China (C.-P.L.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle C.","family":"Van Gelder","sequence":"additional","affiliation":[{"name":"From the Population Health Research Institute, McMaster University, Hamilton, Canada (J.S.H., S.J.C., G.M.N., S.D., E.T., C.A.M.); Evangelisches Krankenhaus Bielefeld, Bielefeld (C.W.I.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); Clinica di Cardiologia, Universit\u00e0 Politecnica delle Marche, Ancona, Italy (A.C.); University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (I.C.V.G.); University of Hong Kong, Queen Mary Hospital, Hong Kong, China (C.-P.L.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chu-Pak","family":"Lau","sequence":"additional","affiliation":[{"name":"From the Population Health Research Institute, McMaster University, Hamilton, Canada (J.S.H., S.J.C., G.M.N., S.D., E.T., C.A.M.); Evangelisches Krankenhaus Bielefeld, Bielefeld (C.W.I.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); Clinica di Cardiologia, Universit\u00e0 Politecnica delle Marche, Ancona, Italy (A.C.); University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (I.C.V.G.); University of Hong Kong, Queen Mary Hospital, Hong Kong, China (C.-P.L.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Gold","sequence":"additional","affiliation":[{"name":"From the Population Health Research Institute, McMaster University, Hamilton, Canada (J.S.H., S.J.C., G.M.N., S.D., E.T., C.A.M.); Evangelisches Krankenhaus Bielefeld, Bielefeld (C.W.I.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); Clinica di Cardiologia, Universit\u00e0 Politecnica delle Marche, Ancona, Italy (A.C.); University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (I.C.V.G.); University of Hong Kong, Queen Mary Hospital, Hong Kong, China (C.-P.L.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Carlson","sequence":"additional","affiliation":[{"name":"From the Population Health Research Institute, McMaster University, Hamilton, Canada (J.S.H., S.J.C., G.M.N., S.D., E.T., C.A.M.); Evangelisches Krankenhaus Bielefeld, Bielefeld (C.W.I.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); Clinica di Cardiologia, Universit\u00e0 Politecnica delle Marche, Ancona, Italy (A.C.); University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (I.C.V.G.); University of Hong Kong, Queen Mary Hospital, Hong Kong, China (C.-P.L.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellison","family":"Themeles","sequence":"additional","affiliation":[{"name":"From the Population Health Research Institute, McMaster University, Hamilton, Canada (J.S.H., S.J.C., G.M.N., S.D., E.T., C.A.M.); Evangelisches Krankenhaus Bielefeld, Bielefeld (C.W.I.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); Clinica di Cardiologia, Universit\u00e0 Politecnica delle Marche, Ancona, Italy (A.C.); University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (I.C.V.G.); University of Hong Kong, Queen Mary Hospital, Hong Kong, China (C.-P.L.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Morillo","sequence":"additional","affiliation":[{"name":"From the Population Health Research Institute, McMaster University, Hamilton, Canada (J.S.H., S.J.C., G.M.N., S.D., E.T., C.A.M.); Evangelisches Krankenhaus Bielefeld, Bielefeld (C.W.I.); J.W. Goethe University, Frankfurt, Germany (S.H.H.); Clinica di Cardiologia, Universit\u00e0 Politecnica delle Marche, Ancona, Italy (A.C.); University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (I.C.V.G.); University of Hong Kong, Queen Mary Hospital, Hong Kong, China (C.-P.L.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01326-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.610303"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071880"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00583-9"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80348-9"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.5.1588"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.7.1954"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.1.87"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000090688.49283.67"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.18.1894"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00464-9"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00385-9"},{"key":"e_1_3_3_14_2","first-page":"311","article-title":"Reverse atrial electrical remodelling following atrial defibrillation as determined by signal-averaged ECG.","volume":"20","author":"Healey JS","year":"2004","unstructured":"Healey JS, Theoret-Patrick P, Green MS, Lemery R, Birnie D, Tang AS. Reverse atrial electrical remodelling following atrial defibrillation as determined by signal-averaged ECG. Can J Cardiol. 2004;20:311\u2013315.","journal-title":"Can J Cardiol"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.046"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.08.027"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.7.1600"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.02.016"},{"key":"e_1_3_3_19_2","first-page":"122","article-title":"Pacemaker-detected atrial tachyarrhythmias and the risk of stroke.","volume":"366","author":"Healey JS","year":"2012","unstructured":"Healey JS, Connolly SJ, Gold MR, Israel CW, Van Gelder IC, Capucci A, Lau CP, Fain E, Yang S, Bailleul C, Morillo CA, Carlson M, Themeles E, Kaufman ES, Hohnloser SH. Pacemaker-detected atrial tachyarrhythmias and the risk of stroke. N Engl J Med. 2012;366:122\u2013131.","journal-title":"N Engl J Med"},{"key":"e_1_3_3_20_2","first-page":"840","article-title":"Ambulatory electrophysiologic properties in pacemaker patients with sinus node disease compared with atrioventricular node disease.","volume":"24","author":"Healey JS","year":"2008","unstructured":"Healey JS, Israel CW, Capucci A, Van Gelder IC, Lau CP, Fain E, Gold MR, Yang S, Morillo CA, Bailleul C, Hohnloser SH, Connolly SJ. Ambulatory electrophysiologic properties in pacemaker patients with sinus node disease compared with atrioventricular node disease. Can J Cardiol. 2008;24:840.","journal-title":"Can J Cardiol"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.10.033"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.10.1242"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy0302.105683"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960240906"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.4065\/76.5.467"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.67.391"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.5.1193"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.58.3.356"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2004.00494.x"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2002.01546.x"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00227-3"}],"container-title":["Circulation: Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.112.970442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:14:02Z","timestamp":1715559242000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.112.970442"}},"subtitle":["Results of the Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial Mechanisms of Atrial Fibrillation Study"],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1161\/CIRCEP.112.970442"],"URL":"https:\/\/doi.org\/10.1161\/circep.112.970442","relation":{},"ISSN":["1941-3149","1941-3084"],"issn-type":[{"value":"1941-3149","type":"print"},{"value":"1941-3084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"2012-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-05-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-06-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}