{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:21:38Z","timestamp":1772112098122,"version":"3.50.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Treatment options for patients with recurrent ventricular arrhythmias refractory to pharmacotherapy and ablation are minimal. Although left cardiac sympathetic denervation (LCSD) is well established in long-QT syndrome, its role in non\u2013long-QT syndrome arrhythmogenic channelopathies and cardiomyopathies is less clear. Here, we report our single-center experience in performing LCSD in this setting.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>In this institutional review board\u2013approved study, we retrospectively reviewed the electronic medical records of all patients (N=91) who had videoscopic LCSD at our institution from 2005 to 2011. Data were analyzed for the subset (n=27) who were denervated for an underlying diagnosis other than autosomal dominant or sporadic long-QT syndrome. The spectrum of arrhythmogenic disease included catecholaminergic polymorphic ventricular tachycardia (n=13), Jervell and Lange-Nielsen syndrome (n=5), idiopathic ventricular fibrillation (n=4), left ventricular noncompaction (n=2), hypertrophic cardiomyopathy (n=1), ischemic cardiomyopathy (n=1), and arrhythmogenic right ventricular cardiomyopathy (n=1). Five patients had LCSD because of high-risk assessment and \u03b2-blocker intolerance, none of whom had a sentinel breakthrough cardiac event at early follow-up. Among the remaining 22 previously symptomatic patients who had LCSD as secondary prevention, all had an attenuation in cardiac events, with 18 having no breakthrough cardiac events so far and 4 having experienced \u22651 post-LCSD breakthrough cardiac event.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>LCSD may represent a substrate-independent antifibrillatory treatment option for patients with life-threatening ventricular arrhythmia syndromes other than long-QT syndrome. The early follow-up seems promising, with a marked reduction in the frequency of cardiac events postdenervation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.112.971754","type":"journal-article","created":{"date-parts":[[2012,7,12]],"date-time":"2012-07-12T04:55:12Z","timestamp":1342068912000},"page":"782-788","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":103,"title":["Videoscopic Left Cardiac Sympathetic Denervation for Patients With Recurrent Ventricular Fibrillation\/Malignant Ventricular Arrhythmia Syndromes Besides Congenital Long-QT Syndrome"],"prefix":"10.1161","volume":"5","author":[{"given":"Mira A.","family":"Coleman","sequence":"first","affiliation":[{"name":"From the Mayo Medical School (M.A.C.), Department of Molecular Pharmacology and Experimental Therapeutics (J.M.B., M.J.A.), Department of Medicine\/Division of Cardiovascular Diseases (J.M.B., M.J.A.), Department of Pediatrics\/Division of Pediatric Cardiology (J.N.J., H.J.O., M.J.A.), Department of Surgery\/Division of Pediatric Surgery, (C.D., C.M.), Mayo Clinic, Rochester, MN.Guest Editor for the article was Kenneth A. Ellenbogen, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Martijn","family":"Bos","sequence":"additional","affiliation":[{"name":"From the Mayo Medical School (M.A.C.), Department of Molecular Pharmacology and Experimental Therapeutics (J.M.B., M.J.A.), Department of Medicine\/Division of Cardiovascular Diseases (J.M.B., M.J.A.), Department of Pediatrics\/Division of Pediatric Cardiology (J.N.J., H.J.O., M.J.A.), Department of Surgery\/Division of Pediatric Surgery, (C.D., C.M.), Mayo Clinic, Rochester, MN.Guest Editor for the article was Kenneth A. Ellenbogen, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan N.","family":"Johnson","sequence":"additional","affiliation":[{"name":"From the Mayo Medical School (M.A.C.), Department of Molecular Pharmacology and Experimental Therapeutics (J.M.B., M.J.A.), Department of Medicine\/Division of Cardiovascular Diseases (J.M.B., M.J.A.), Department of Pediatrics\/Division of Pediatric Cardiology (J.N.J., H.J.O., M.J.A.), Department of Surgery\/Division of Pediatric Surgery, (C.D., C.M.), Mayo Clinic, Rochester, MN.Guest Editor for the article was Kenneth A. Ellenbogen, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi J.","family":"Owen","sequence":"additional","affiliation":[{"name":"From the Mayo Medical School (M.A.C.), Department of Molecular Pharmacology and Experimental Therapeutics (J.M.B., M.J.A.), Department of Medicine\/Division of Cardiovascular Diseases (J.M.B., M.J.A.), Department of Pediatrics\/Division of Pediatric Cardiology (J.N.J., H.J.O., M.J.A.), Department of Surgery\/Division of Pediatric Surgery, (C.D., C.M.), Mayo Clinic, Rochester, MN.Guest Editor for the article was Kenneth A. Ellenbogen, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Deschamps","sequence":"additional","affiliation":[{"name":"From the Mayo Medical School (M.A.C.), Department of Molecular Pharmacology and Experimental Therapeutics (J.M.B., M.J.A.), Department of Medicine\/Division of Cardiovascular Diseases (J.M.B., M.J.A.), Department of Pediatrics\/Division of Pediatric Cardiology (J.N.J., H.J.O., M.J.A.), Department of Surgery\/Division of Pediatric Surgery, (C.D., C.M.), Mayo Clinic, Rochester, MN.Guest Editor for the article was Kenneth A. Ellenbogen, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Moir","sequence":"additional","affiliation":[{"name":"From the Mayo Medical School (M.A.C.), Department of Molecular Pharmacology and Experimental Therapeutics (J.M.B., M.J.A.), Department of Medicine\/Division of Cardiovascular Diseases (J.M.B., M.J.A.), Department of Pediatrics\/Division of Pediatric Cardiology (J.N.J., H.J.O., M.J.A.), Department of Surgery\/Division of Pediatric Surgery, (C.D., C.M.), Mayo Clinic, Rochester, MN.Guest Editor for the article was Kenneth A. Ellenbogen, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Ackerman","sequence":"additional","affiliation":[{"name":"From the Mayo Medical School (M.A.C.), Department of Molecular Pharmacology and Experimental Therapeutics (J.M.B., M.J.A.), Department of Medicine\/Division of Cardiovascular Diseases (J.M.B., M.J.A.), Department of Pediatrics\/Division of Pediatric Cardiology (J.N.J., H.J.O., M.J.A.), Department of Surgery\/Division of Pediatric Surgery, (C.D., C.M.), Mayo Clinic, Rochester, MN.Guest Editor for the article was Kenneth A. 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