{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:34:47Z","timestamp":1791855287435,"version":"4.3.4"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Implantable cardioverter-defibrillators (ICDs), the first line of therapy for preventing sudden cardiac death in high-risk patients, deliver appropriate shocks for termination of ventricular tachycardia (VT)\/ventricular fibrillation. A common shortcoming of ICDs is imperfect rhythm discrimination, resulting in the delivery of inappropriate shocks for atrial fibrillation (AF). An underexplored area for rhythm discrimination is the difference in dynamic properties between AF and VT\/ventricular fibrillation. We hypothesized that the higher entropy of rapid cardiac rhythms preceding ICD shocks distinguishes AF from VT\/ventricular fibrillation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>In a multicenter, prospective, observational study of patients with primary prevention ICDs, 119 patients received shocks from ICDs with stored, retrievable intracardiac electrograms. Blinded adjudication revealed shocks were delivered for VT\/ventricular fibrillation (62%), AF (23%), and supraventricular tachycardia (15%). Entropy estimation of only 9 ventricular intervals before ICD shocks accurately distinguished AF (receiver operating characteristic curve area, 0.98; 95% confidence intervals, 0.93\u20131.0) and outperformed contemporary ICD rhythm discrimination algorithms.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>This new strategy for AF discrimination based on entropy estimation expands on simpler concepts of variability, performs well at fast heart rates, and has potential for broad clinical application.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.113.000034","type":"journal-article","created":{"date-parts":[[2013,5,18]],"date-time":"2013-05-18T01:52:36Z","timestamp":1368841956000},"page":"555-561","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Dynamic Analysis of Cardiac Rhythms for Discriminating Atrial Fibrillation From Lethal Ventricular Arrhythmias"],"prefix":"10.1161","volume":"6","author":[{"given":"Deeptankar","family":"DeMazumder","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.D., A.C., R.G.W., S.R.J., G.F.T.); Division of Cardiology (D.E.L., T.J.M., J.R.M.) and Department of Statistics (D.E.L.), University of Virginia, Charlottesville, VA; and Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas E.","family":"Lake","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.D., A.C., R.G.W., S.R.J., G.F.T.); Division of Cardiology (D.E.L., T.J.M., J.R.M.) and Department of Statistics (D.E.L.), University of Virginia, Charlottesville, VA; and Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Cheng","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.D., A.C., R.G.W., S.R.J., G.F.T.); Division of Cardiology (D.E.L., T.J.M., J.R.M.) and Department of Statistics (D.E.L.), University of Virginia, Charlottesville, VA; and Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis J.","family":"Moss","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.D., A.C., R.G.W., S.R.J., G.F.T.); Division of Cardiology (D.E.L., T.J.M., J.R.M.) and Department of Statistics (D.E.L.), University of Virginia, Charlottesville, VA; and Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliseo","family":"Guallar","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.D., A.C., R.G.W., S.R.J., G.F.T.); Division of Cardiology (D.E.L., T.J.M., J.R.M.) and Department of Statistics (D.E.L.), University of Virginia, Charlottesville, VA; and Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Weiss","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.D., A.C., R.G.W., S.R.J., G.F.T.); Division of Cardiology (D.E.L., T.J.M., J.R.M.) and Department of Statistics (D.E.L.), University of Virginia, Charlottesville, VA; and Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Jones","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.D., A.C., R.G.W., S.R.J., G.F.T.); Division of Cardiology (D.E.L., T.J.M., J.R.M.) and Department of Statistics (D.E.L.), University of Virginia, Charlottesville, VA; and Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon F.","family":"Tomaselli","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.D., A.C., R.G.W., S.R.J., G.F.T.); Division of Cardiology (D.E.L., T.J.M., J.R.M.) and Department of Statistics (D.E.L.), University of Virginia, Charlottesville, VA; and Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Randall","family":"Moorman","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.D., A.C., R.G.W., S.R.J., G.F.T.); Division of Cardiology (D.E.L., T.J.M., J.R.M.) and Department of Statistics (D.E.L.), University of Virginia, Charlottesville, VA; and Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2008.06.003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013474"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur195"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-008-0032-y"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00643.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.08.012"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2006.00465.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-009-9740-z"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1995.tb00385.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1999.tb01261.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.1.162"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02345439"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2010.2096506"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.059"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.10.004"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.634113"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.110.961243"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.073"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.594531"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01825.x"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.11.048"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01958.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071098"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.46.5.451"},{"issue":"4","key":"e_1_3_3_27_2","first-page":"H1643","article-title":"Physiological time-series analysis: what does regularity quantify?","volume":"266","author":"Pincus SM","year":"1994","unstructured":"Pincus SM, Goldberger AL. Physiological time-series analysis: what does regularity quantify? Am J Physiol. 1994;266(4 Pt 2):H1643\u2013H1656.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(04)84011-4"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.278.6.H2039"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00561.2010"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.93.5.1043"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015912"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.629428"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00134.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105575"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2007.00682.x"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1998.tb01098.x"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.06.044"}],"container-title":["Circulation: Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.113.000034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:18:09Z","timestamp":1715559489000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.113.000034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1161\/CIRCEP.113.000034"],"URL":"https:\/\/doi.org\/10.1161\/circep.113.000034","relation":{},"ISSN":["1941-3149","1941-3084"],"issn-type":[{"value":"1941-3149","type":"print"},{"value":"1941-3084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"2012-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}