{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:08:35Z","timestamp":1788671315972,"version":"build-2803163510"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Long QT syndrome (LQTS) is a potentially lethal but highly treatable cardiac channelopathy. Treatment options include pharmacotherapy, device therapy, and left cardiac sympathetic denervation (LCSD). Here, we sought to determine the characteristics of LQTS patients who have had \u22651 LQTS-related breakthrough cardiac event (BCE) after LCSD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We performed retrospective chart review for 52 consecutive patients (24 males; mean age at diagnosis, 10.0\u00b110 years; mean QTc, 528\u00b174 ms) with LQTS who underwent LCSD between 2005 and 2010 (mean age at LCSD, 14.1\u00b110 years) and have been followed up for 3.6\u00b11.3 years. A BCE was defined as either (1) an appropriate ventricular fibrillation-terminating implantable cardioverter defibrillator shock or (2) arrhythmogenic syncope, seizures, or aborted cardiac arrest after LCSD. Thirty-three patients (61%) had LCSD as primary prevention because of either high-risk assessment or \u03b2-blocker intolerance. So far, 12 of 52 (23%) patients (7 males) have experienced \u22651 BCE post LCSD. The clinical phenotype of patients with BCEs was significantly more severe than patients without a BCE. No BCEs were seen in patients undergoing LCSD for \u03b2-blocker intolerance (0\/12 versus 17\/40;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Although a marked reduction in number of cardiac events is usually seen after LCSD, \u224850% of high-risk LQTS patients have experienced \u22651 post-LCSD breakthrough. Therefore, LCSD must not be viewed as curative or as an alternative in implantable cardioverter defibrillator for high-risk patients. Prophylactic LCSD may provide another option to counter a suboptimal quality of life resulting from medication-related side effects.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.113.000102","type":"journal-article","created":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T06:57:09Z","timestamp":1370069829000},"page":"705-711","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":99,"title":["Left Cardiac Sympathetic Denervation in Long QT Syndrome"],"prefix":"10.1161","volume":"6","author":[{"given":"J. Martijn","family":"Bos","sequence":"first","affiliation":[{"name":"From the Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology &amp; Experimental Therapeutics (J.M.B., M.J.A.), Division of Pediatric Cardiology, Department of Pediatric &amp; Adolescent Medicine (K.M.B., J.N.J., M.J.A.), Division of Pediatric Surgery, Department of Surgery (C.M.), and Division of Cardiovascular Diseases, Department of Medicine (M.J.A.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy M.","family":"Bos","sequence":"additional","affiliation":[{"name":"From the Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology &amp; Experimental Therapeutics (J.M.B., M.J.A.), Division of Pediatric Cardiology, Department of Pediatric &amp; Adolescent Medicine (K.M.B., J.N.J., M.J.A.), Division of Pediatric Surgery, Department of Surgery (C.M.), and Division of Cardiovascular Diseases, Department of Medicine (M.J.A.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan N.","family":"Johnson","sequence":"additional","affiliation":[{"name":"From the Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology &amp; Experimental Therapeutics (J.M.B., M.J.A.), Division of Pediatric Cardiology, Department of Pediatric &amp; Adolescent Medicine (K.M.B., J.N.J., M.J.A.), Division of Pediatric Surgery, Department of Surgery (C.M.), and Division of Cardiovascular Diseases, Department of Medicine (M.J.A.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Moir","sequence":"additional","affiliation":[{"name":"From the Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology &amp; Experimental Therapeutics (J.M.B., M.J.A.), Division of Pediatric Cardiology, Department of Pediatric &amp; Adolescent Medicine (K.M.B., J.N.J., M.J.A.), Division of Pediatric Surgery, Department of Surgery (C.M.), and Division of Cardiovascular Diseases, Department of Medicine (M.J.A.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Ackerman","sequence":"additional","affiliation":[{"name":"From the Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology &amp; Experimental Therapeutics (J.M.B., M.J.A.), Division of Pediatric Cardiology, Department of Pediatric &amp; Adolescent Medicine (K.M.B., J.N.J., M.J.A.), Division of Pediatric Surgery, Department of Surgery (C.M.), and Division of Cardiovascular Diseases, Department of Medicine (M.J.A.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0504-463"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.863209"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.05.021"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.03.024"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197110142851607"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000125523.14403.1e"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708006"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-84628-854-8_33"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.69.4.790"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1984.tb20785.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90420-3"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.2.503"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.929703"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.03.056"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.6.616"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.11.1341"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-003-0567-3"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.10.017"}],"container-title":["Circulation: Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.113.000102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:18:39Z","timestamp":1715559519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.113.000102"}},"subtitle":["Analysis of Therapeutic Nonresponders"],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1161\/CIRCEP.113.000102"],"URL":"https:\/\/doi.org\/10.1161\/circep.113.000102","relation":{},"ISSN":["1941-3149","1941-3084"],"issn-type":[{"value":"1941-3149","type":"print"},{"value":"1941-3084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"2012-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}