{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:44:41Z","timestamp":1776897881169,"version":"3.51.2"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>MRI-detected brain lesions are common after left atrial catheter ablation for symptomatic atrial fibrillation. The clinical relevance of these acute ischemic lesions is not fully understood, but ablation-related cerebral injury could contribute to cognitive dysfunction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              In the prospective Mesh Ablator versus Cryoballoon Pulmonary Vein Ablation of Symptomatic Paroxysmal Atrial Fibrillation (MACPAF) study, serial 3-T brain MRIs and neuropsychological assessment were performed to analyze the rate of ablation-related brain lesions and their effect on cognitive function. Thirty-seven patients with paroxysmal atrial fibrillation (median age, 63.0 [interquartile range, 57\u201368] years; 41% female; median CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              VASc score 2 [interquartile range, 1\u20133]) underwent 41 ablation procedures according to study criteria. None of these patients had overt neurological deficits after ablation. High-resolution diffusion-weighted imaging, performed within 48 hours after ablation, showed that new brain lesions (range, 1\u201317) were present in 16 (43.2%) patients after 18 (43.9%) left atrial catheter ablation procedures. Follow-up MRI at 6 months (median, 6.5; interquartile range, 6\u20137) revealed that 7 (12.5%) of the 56 total acute brain lesions after ablation formed a persistent glial scar in 5 (31.3%) patients. Large diffusion-weighted imaging lesions and a corresponding fluid-attenuated inversion recovery lesion 48 hours after ablation predicted lesion persistence on 6-month follow-up. Neither persistent brain lesions nor the ablation procedure itself had a significant effect on attention or executive functions, short-term memory, or verbal and nonverbal learning after 6 months.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Ablation-related acute ischemic brain lesions persist to some extent but do not cause cognitive impairment 6 months after the ablation procedure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT01061931.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.113.000174","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T00:18:27Z","timestamp":1377821907000},"page":"843-850","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":59,"title":["Neuropsychological Effects of MRI-Detected Brain Lesions After Left Atrial Catheter Ablation for Atrial Fibrillation"],"prefix":"10.1161","volume":"6","author":[{"given":"Juliane","family":"Herm","sequence":"first","affiliation":[{"name":"From the Department of Neurology (J.H., U.A.K., M.E., K.G.H.), Center for Stroke Research Berlin (J.H., J.B.F., C.K., C.W., P.B., M.E., K.G.H.), Department of Cardiology and Pneumology (L.K., H.-P.S., A.S.), and Excellence Cluster NeuroCure (M.E.), Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen B.","family":"Fiebach","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.H., U.A.K., M.E., K.G.H.), Center for Stroke Research Berlin (J.H., J.B.F., C.K., C.W., P.B., M.E., K.G.H.), Department of Cardiology and Pneumology (L.K., H.-P.S., A.S.), and Excellence Cluster NeuroCure (M.E.), Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Koch","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.H., U.A.K., M.E., K.G.H.), Center for Stroke Research Berlin (J.H., J.B.F., C.K., C.W., P.B., M.E., K.G.H.), Department of Cardiology and Pneumology (L.K., H.-P.S., A.S.), and Excellence Cluster NeuroCure (M.E.), Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute A.","family":"Kopp","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.H., U.A.K., M.E., K.G.H.), Center for Stroke Research Berlin (J.H., J.B.F., C.K., C.W., P.B., M.E., K.G.H.), Department of Cardiology and Pneumology (L.K., H.-P.S., A.S.), and Excellence Cluster NeuroCure (M.E.), Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Kunze","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.H., U.A.K., M.E., K.G.H.), Center for Stroke Research Berlin (J.H., J.B.F., C.K., C.W., P.B., M.E., K.G.H.), Department of Cardiology and Pneumology (L.K., H.-P.S., A.S.), and Excellence Cluster NeuroCure (M.E.), Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Wollboldt","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.H., U.A.K., M.E., K.G.H.), Center for Stroke Research Berlin (J.H., J.B.F., C.K., C.W., P.B., M.E., K.G.H.), Department of Cardiology and Pneumology (L.K., H.-P.S., A.S.), and Excellence Cluster NeuroCure (M.E.), Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Brunecker","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.H., U.A.K., M.E., K.G.H.), Center for Stroke Research Berlin (J.H., J.B.F., C.K., C.W., P.B., M.E., K.G.H.), Department of Cardiology and Pneumology (L.K., H.-P.S., A.S.), and Excellence Cluster NeuroCure (M.E.), Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz-Peter","family":"Schultheiss","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.H., U.A.K., M.E., K.G.H.), Center for Stroke 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