{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:01:15Z","timestamp":1762506075273},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Substrate abnormality in pulmonary vein (PV) antrum plays a critical role in mechanism of atrial fibrillation (AF). The present study compares the strategy of PV antrum radial\u2013linear (PAR) ablation to encircling PV isolation for paroxysmal AF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              A total of 86 patients with paroxysmal AF were randomly assigned to PAR ablation group or PV isolation group. The average procedure time was 161\u00b121 minutes in PAR ablation group and 199\u00b139 minutes in PV isolation group (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). The average fluoroscopy time was 25\u00b15 minutes in PAR ablation group and 32\u00b19 minutes in PV isolation group (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). At 14 (15\u201312) months of follow-up after single procedure, 31 of 42 (74%) patients in PAR ablation group and 22 of 44 patients (50%) in PV isolation group had no recurrence of AF off antiarrhythmic drug (\n              <jats:italic>P<\/jats:italic>\n              =0.0249); and 36 of 42 patients (86%) in PAR ablation group and 26 of 44 patients (59%) in PV isolation group had no recurrence of AF with antiarrhythmic drug (\n              <jats:italic>P<\/jats:italic>\n              =0.006). In addition, PAR ablation resulted in greater reduction of left atrial diameter than encircling PV isolation. Multivariable Cox regression analysis showed that only ablation strategy was independently associated with AF recurrence (hazard ratio, 0.31; 95% confidence interval, 0.12\u20130.78;\n              <jats:italic>P<\/jats:italic>\n              =0.013). No major adverse event related to the procedures occurred.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>This study suggests that PAR ablation is a potentially effective strategy for treatment of paroxysmal AF warranting further investigation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.chictr.org\">http:\/\/www.chictr.org<\/jats:ext-link>\n              ; Unique identifier: ChiCTR-TRC-11001191.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.113.000196","type":"journal-article","created":{"date-parts":[[2013,2,23]],"date-time":"2013-02-23T13:04:25Z","timestamp":1361624665000},"page":"310-317","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Pulmonary Antrum Radial\u2013Linear Ablation for Paroxysmal Atrial Fibrillation"],"prefix":"10.1161","volume":"6","author":[{"given":"Xue","family":"Zhao","sequence":"first","affiliation":[{"name":"From the Division of Cardiac Electrophysiology, Translational Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, China (X.Z., J.Z., J.H., D.L., Y. Zhu, X.M., J.S., F.Y., Y.G.); Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China (W.L., L.D., X.G.); Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University, Shanghai, China (Y.X.); Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China (Y...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayou","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Division of Cardiac Electrophysiology, Translational Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, China (X.Z., J.Z., J.H., D.L., Y. Zhu, X.M., J.S., F.Y., Y.G.); Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China (W.L., L.D., X.G.); Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University, Shanghai, China (Y.X.); Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China (Y...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqiang","family":"Hu","sequence":"additional","affiliation":[{"name":"From the Division of Cardiac Electrophysiology, Translational Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, China (X.Z., J.Z., J.H., D.L., Y. Zhu, X.M., J.S., F.Y., Y.G.); Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China (W.L., L.D., X.G.); Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University, Shanghai, China (Y.X.); Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China (Y...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dening","family":"Liao","sequence":"additional","affiliation":[{"name":"From the Division of Cardiac Electrophysiology, Translational Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, China (X.Z., J.Z., J.H., D.L., Y. Zhu, X.M., J.S., F.Y., Y.G.); Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China (W.L., L.D., X.G.); Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University, Shanghai, China (Y.X.); Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China (Y...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinxiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"From the Division of Cardiac Electrophysiology, Translational Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, China (X.Z., J.Z., J.H., D.L., Y. Zhu, X.M., J.S., F.Y., Y.G.); Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China (W.L., L.D., X.G.); Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University, Shanghai, China (Y.X.); Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China (Y...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Mei","sequence":"additional","affiliation":[{"name":"From the Division of Cardiac Electrophysiology, Translational Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, China (X.Z., J.Z., J.H., D.L., Y. Zhu, X.M., J.S., F.Y., Y.G.); Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China (W.L., L.D., X.G.); Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University, Shanghai, China (Y.X.); Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China (Y...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Sheng","sequence":"additional","affiliation":[{"name":"From the Division of Cardiac Electrophysiology, Translational Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, China (X.Z., J.Z., J.H., D.L., Y. Zhu, X.M., J.S., F.Y., Y.G.); Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China (W.L., L.D., X.G.); Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University, Shanghai, China (Y.X.); Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China (Y...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Yuan","sequence":"additional","affiliation":[{"name":"From the Division of Cardiac Electrophysiology, Translational Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, China (X.Z., J.Z., J.H., D.L., Y. Zhu, X.M., J.S., F.Y., Y.G.); Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China (W.L., L.D., X.G.); Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University, Shanghai, China (Y.X.); Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China (Y...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Gui","sequence":"additional","affiliation":[{"name":"From the Division of Cardiac Electrophysiology, Translational Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, China (X.Z., J.Z., J.H., D.L., Y. Zhu, X.M., J.S., F.Y., Y.G.); Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China (W.L., L.D., X.G.); Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University, Shanghai, China (Y.X.); Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China (Y...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenliang","family":"Lu","sequence":"additional","affiliation":[{"name":"From the Division of Cardiac Electrophysiology, Translational Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, China (X.Z., J.Z., J.H., D.L., Y. Zhu, X.M., J.S., F.Y., Y.G.); Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China (W.L., L.D., X.G.); Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University, Shanghai, China (Y.X.); Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China (Y...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Dai","sequence":"additional","affiliation":[{"name":"From the Division of Cardiac Electrophysiology, Translational Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, China (X.Z., J.Z., J.H., D.L., Y. Zhu, X.M., J.S., F.Y., Y.G.); Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China (W.L., L.D., X.G.); Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University, Shanghai, China (Y.X.); Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China (Y...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingui","family":"Guo","sequence":"additional","affiliation":[{"name":"From the Division of Cardiac Electrophysiology, Translational Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, China (X.Z., J.Z., J.H., D.L., Y. Zhu, X.M., J.S., F.Y., Y.G.); Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China (W.L., L.D., X.G.); Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University, Shanghai, China (Y.X.); Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China (Y...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawei","family":"Xu","sequence":"additional","affiliation":[{"name":"From the Division of Cardiac Electrophysiology, Translational Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, China (X.Z., J.Z., J.H., D.L., Y. Zhu, X.M., J.S., F.Y., Y.G.); Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China (W.L., L.D., X.G.); Department of Cardiology, Shanghai Tenth People\u2019s Hospital, Tongji University, Shanghai, China (Y.X.); Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China (Y...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzhou","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Division of Cardiac Electrophysiology, Translational Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, China (X.Z., J.Z., J.H., D.L., Y. 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