{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:32:00Z","timestamp":1785936720367,"version":"3.56.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Previous population studies have found an association between electrocardiographic T-wave morphology parameters and cardiovascular mortality, but their relationship to sudden cardiac death (SCD) is not clear. To our knowledge, there are no follow-up studies assessing the association between electrocardiographic T-wave peak to T-wave end interval (TPE) and SCD. We assessed the predictive value of electrocardiographic T-wave morphology parameters and TPE for SCD in an adult general population sample.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              A total of 4 T-wave morphology parameters (principal component analysis ratio, T-wave morphology dispersion, total cosine R-to-T, T-wave residuum) as well as TPE were measured from digital standard 12-lead ECGs in 5618 adults (46% men; mean age 50.9\u00b112.5 years) participating in the Finnish population\u2013based Health 2000 Study. After a mean follow-up time of 7.7\u00b11.4 years, 72 SCDs had occurred. In univariable analyses, all T-wave morphology parameters were associated with an increased SCD risk. In multivariable Cox models, T-wave morphology dispersion and total cosine R-to-T remained as predictors of SCD, with T-wave morphology dispersion showing the highest SCD risk (hazard ratio of 1.4 [95% confidence interval 1.1\u22121.7,\n              <jats:italic>P<\/jats:italic>\n              =0.001] per 1 SD increase in the log\n              <jats:sub>e<\/jats:sub>\n              T-wave morphology dispersion). In contrast, TPE was not associated with SCD in univariable or multivariable analyses.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Electrocardiographic T-wave morphology parameters describing the 3-dimensional shape of the T-wave stratify SCD risk in the general population, but we did not find an association between TPE and SCD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.113.000356","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T17:11:37Z","timestamp":1374685897000},"page":"690-696","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":92,"title":["Predictive Value of Electrocardiographic T-Wave Morphology Parameters and T-Wave Peak to T-Wave End Interval for Sudden Cardiac Death in the General Population"],"prefix":"10.1161","volume":"6","author":[{"given":"Kimmo","family":"Porthan","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland (K.P., M.V., L.T., M.S.N., L.O.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (A.S.H., V.S.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland (A.J.); Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu and University Central Hospital of Oulu, Finland (J.T.T...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Viitasalo","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland (K.P., M.V., L.T., M.S.N., L.O.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (A.S.H., V.S.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland (A.J.); Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu and University Central Hospital of Oulu, Finland (J.T.T...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauri","family":"Toivonen","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland (K.P., M.V., L.T., M.S.N., L.O.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (A.S.H., V.S.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland (A.J.); Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu and University Central Hospital of Oulu, Finland (J.T.T...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki S.","family":"Havulinna","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland (K.P., M.V., L.T., M.S.N., L.O.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (A.S.H., V.S.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland (A.J.); Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu and University Central Hospital of Oulu, Finland (J.T.T...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Jula","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland (K.P., M.V., L.T., M.S.N., L.O.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (A.S.H., V.S.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland (A.J.); Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu and University Central Hospital of Oulu, Finland (J.T.T...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jani T.","family":"Tikkanen","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland (K.P., M.V., L.T., M.S.N., L.O.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (A.S.H., V.S.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland (A.J.); Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu and University Central Hospital of Oulu, Finland (J.T.T...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"V\u00e4\u00e4n\u00e4nen","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland (K.P., M.V., L.T., M.S.N., L.O.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (A.S.H., V.S.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland (A.J.); Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu and University Central Hospital of Oulu, Finland (J.T.T...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku S.","family":"Nieminen","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland (K.P., M.V., L.T., M.S.N., L.O.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (A.S.H., V.S.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland (A.J.); Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu and University Central Hospital of Oulu, Finland (J.T.T...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki V.","family":"Huikuri","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland (K.P., M.V., L.T., M.S.N., L.O.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (A.S.H., V.S.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland (A.J.); Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu and University Central Hospital of Oulu, Finland (J.T.T...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Newton-Cheh","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland (K.P., M.V., L.T., M.S.N., L.O.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (A.S.H., V.S.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland (A.J.); Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu and University Central Hospital of Oulu, Finland (J.T.T...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veikko","family":"Salomaa","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland (K.P., M.V., L.T., M.S.N., L.O.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (A.S.H., V.S.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland (A.J.); Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu and University Central Hospital of Oulu, Finland (J.T.T...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse","family":"Oikarinen","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland (K.P., M.V., L.T., M.S.N., L.O.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (A.S.H., V.S.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland (A.J.); Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu and University Central Hospital of Oulu, Finland (J.T.T...."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.023838"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.023846"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000085071.28695.c4"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.067"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.110.960658"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0602.103585"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.40808.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104598"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00203-3"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.104.496091"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.537415"},{"key":"e_1_3_3_14_2","volume-title":"Methodology Report, Health 2000 Survey","author":"Heistaro S","year":"2008","unstructured":"Heistaro S. 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