{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:14:13Z","timestamp":1788498853807,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The aim of this prospective randomized study was to assess whether an early reablation was superior to antiarrhythmic drug (AAD) therapy in patients with previous failed pulmonary vein isolation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Patients with paroxysmal atrial fibrillation (AF) eligible for AAD therapy or reablation after a previously failed initial pulmonary vein isolation procedure were eligible for this study and were followed up for 3 years to assess rhythm by means of an implanted cardiac monitor. After the blanking period postablation, 154 patients had symptomatic AF recurrences and were randomized to AAD (n=77) or repulmonary vein isolation (n=77). At the end of follow-up, 61 (79%) patients in the AAD group and 19 (25%) patients in the reablation group demonstrated AF% progression (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). The AF% at 36 months was significantly greater in the AAD group compared with patients in the reablation group (18.8\u00b111.4% versus 5.6\u00b19.5%, respectively;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). In addition, 18 (23%) patients in the AAD group and 3 (4%) patients in the reablation group progressed to persistent AF (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). Furthermore, 45 (58%) of the 77 reablation group patients were free of AF\/atrial tachycardia on no AADs; in contrast, in the AAD group, only 9 (12%) of the 77 patients were free of AF\/atrial tachycardia (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) throughout follow-up.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Redo AF ablation was substantially more effective than AAD in reducing the progression and prevalence of AF after the failure of an initial ablation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT01709682.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.113.000495","type":"journal-article","created":{"date-parts":[[2013,6,8]],"date-time":"2013-06-08T03:14:14Z","timestamp":1370661254000},"page":"754-760","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Progression of Atrial Fibrillation After a Failed Initial Ablation Procedure in Patients With Paroxysmal Atrial Fibrillation"],"prefix":"10.1161","volume":"6","author":[{"given":"Evgeny","family":"Pokushalov","sequence":"first","affiliation":[{"name":"From the State Research Institute of Circulation Pathology, Novosibirsk, Russia (E.P., A.R., S.A., V.B., D.L., S.B., A.K.); Medtronic Bakken Research Center, Maastricht, The Netherlands (M.D.M.); The Valley Health System and Columbia University College of Physicians and Surgeons, New York, NY (S.M., J.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Romanov","sequence":"additional","affiliation":[{"name":"From the State Research Institute of Circulation Pathology, Novosibirsk, Russia (E.P., A.R., S.A., V.B., D.L., S.B., A.K.); Medtronic Bakken Research Center, Maastricht, The Netherlands (M.D.M.); The Valley Health System and Columbia University College of Physicians and Surgeons, New York, NY (S.M., J.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"De Melis","sequence":"additional","affiliation":[{"name":"From the State Research Institute of Circulation Pathology, Novosibirsk, Russia (E.P., A.R., S.A., V.B., D.L., S.B., A.K.); Medtronic Bakken Research Center, Maastricht, The Netherlands (M.D.M.); The Valley Health System and Columbia University College of Physicians and Surgeons, New York, NY (S.M., J.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Artyomenko","sequence":"additional","affiliation":[{"name":"From the State Research Institute of Circulation Pathology, Novosibirsk, Russia (E.P., A.R., S.A., V.B., D.L., S.B., A.K.); Medtronic Bakken Research Center, Maastricht, The Netherlands (M.D.M.); The Valley Health System and Columbia University College of Physicians and Surgeons, New York, NY (S.M., J.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Baranova","sequence":"additional","affiliation":[{"name":"From the State Research Institute of Circulation Pathology, Novosibirsk, Russia (E.P., A.R., S.A., V.B., D.L., S.B., A.K.); Medtronic Bakken Research Center, Maastricht, The Netherlands (M.D.M.); The Valley Health System and Columbia University College of Physicians and Surgeons, New York, NY (S.M., J.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Losik","sequence":"additional","affiliation":[{"name":"From the State Research Institute of Circulation Pathology, Novosibirsk, Russia (E.P., A.R., S.A., V.B., D.L., S.B., A.K.); Medtronic Bakken Research Center, Maastricht, The Netherlands (M.D.M.); The Valley Health System and Columbia University College of Physicians and Surgeons, New York, NY (S.M., J.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevda","family":"Bairamova","sequence":"additional","affiliation":[{"name":"From the State Research Institute of Circulation Pathology, Novosibirsk, Russia (E.P., A.R., S.A., V.B., D.L., S.B., A.K.); Medtronic Bakken Research Center, Maastricht, The Netherlands (M.D.M.); The Valley Health System and Columbia University College of Physicians and Surgeons, New York, NY (S.M., J.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Karaskov","sequence":"additional","affiliation":[{"name":"From the State Research Institute of Circulation Pathology, Novosibirsk, Russia (E.P., A.R., S.A., V.B., D.L., S.B., A.K.); Medtronic Bakken Research Center, Maastricht, The Netherlands (M.D.M.); The Valley Health System and Columbia University College of Physicians and Surgeons, New York, NY (S.M., J.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneet","family":"Mittal","sequence":"additional","affiliation":[{"name":"From the State Research Institute of Circulation Pathology, Novosibirsk, Russia (E.P., A.R., S.A., V.B., D.L., S.B., A.K.); Medtronic Bakken Research Center, Maastricht, The Netherlands (M.D.M.); The Valley Health System and Columbia University College of Physicians and Surgeons, New York, NY (S.M., J.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"From the State Research Institute of Circulation Pathology, Novosibirsk, Russia (E.P., A.R., S.A., V.B., D.L., S.B., A.K.); Medtronic Bakken Research Center, Maastricht, The Netherlands (M.D.M.); The Valley Health System and Columbia University College of Physicians and Surgeons, New York, NY (S.M., J.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.177292"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000072767.89944.6e"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.10.946"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80348-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.12.016"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.21.2634"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi583"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.08.037"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.772582"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.824789"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.109.859116"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.111.964809"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12038"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.03.021"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.109.877852"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01923.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.040"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.955393"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.08.011"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.112.098079"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.09.053"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/eupc.1998.0008"}],"container-title":["Circulation: Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.113.000495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:18:21Z","timestamp":1715559501000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.113.000495"}},"subtitle":["A Randomized Comparison of Drug Therapy Versus Reablation"],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1161\/CIRCEP.113.000495"],"URL":"https:\/\/doi.org\/10.1161\/circep.113.000495","relation":{},"ISSN":["1941-3149","1941-3084"],"issn-type":[{"value":"1941-3149","type":"print"},{"value":"1941-3084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"2013-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}