{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T14:22:18Z","timestamp":1782570138771,"version":"3.54.5"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Neonatal electrocardiographic screening is used to screen infants with prolonged QT intervals, as previously shown in whites. However, this procedure needs to be confirmed in other ethnic groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              In 8 areas in Japan, an ECG was recorded in 4285 infants at 1-month medical checkup. A prospective study showed that a provisional criterion of QTc \u2265470 ms was appropriate for infants. To assess the validity of the criterion, all infants with a QTc between 460 and 470 ms were followed up. Five infants had a QTc \u2265470 ms. Four infants were diagnosed with prolonged QT intervals from follow-up ECGs. Four infants showed no symptoms and did not have a family history of long-QT syndrome. Two infants showed progressive prolongation of QT intervals, and medication was started. Genetic testing was performed in 3 of 4 infants with prolonged QT intervals, and it revealed a\n              <jats:italic>KCNH2<\/jats:italic>\n              mutation (3065 delT, L1021fs+34X) in 1 infant. One infant with a QTc \u2265470 ms and 2 infants with a QTc between 460 and 470 ms showed a decline in their QTc values during follow-up. The study screened another infant with Wolff\u2013Parkinson\u2013White syndrome who was diagnosed with noncompaction before symptoms appeared.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Neonatal electrocardiographic screening can identify infants likely to be affected by long-QT syndrome in the Japanese population, as already shown in whites. This screening may also be useful in identifying other important cardiac diseases.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.113.000619","type":"journal-article","created":{"date-parts":[[2013,9,14]],"date-time":"2013-09-14T03:16:10Z","timestamp":1379128570000},"page":"932-938","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Electrocardiographic Screening of 1-Month-Old Infants for Identifying Prolonged QT Intervals"],"prefix":"10.1161","volume":"6","author":[{"given":"Masao","family":"Yoshinaga","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan (M.Y., Y.K.); Department of the Cardiovascular System, Fukuoka Children\u2019s Hospital and Medical Center for Infectious Diseases, Fukuoka, Japan (H.U.); Department of Pediatrics, Niigata City General Hospital, Niigata, Japan (S.S.); Department of Rehabilitation, Aichi Saiseikai Rehabilitation Hospital, Nagoya, Japan (N.T., M.N.); Departments of Child Health (H.H.) and Epidemiology (H.T.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroya","family":"Ushinohama","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan (M.Y., Y.K.); Department of the Cardiovascular System, Fukuoka Children\u2019s Hospital and Medical Center for Infectious Diseases, Fukuoka, Japan (H.U.); Department of Pediatrics, Niigata City General Hospital, Niigata, Japan (S.S.); Department of Rehabilitation, Aichi Saiseikai Rehabilitation Hospital, Nagoya, Japan (N.T., M.N.); Departments of Child Health (H.H.) and Epidemiology (H.T.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Sato","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan (M.Y., Y.K.); Department of the Cardiovascular System, Fukuoka Children\u2019s Hospital and Medical Center for Infectious Diseases, Fukuoka, Japan (H.U.); Department of Pediatrics, Niigata City General Hospital, Niigata, Japan (S.S.); Department of Rehabilitation, Aichi Saiseikai Rehabilitation Hospital, Nagoya, Japan (N.T., M.N.); Departments of Child Health (H.H.) and Epidemiology (H.T.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Tauchi","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan (M.Y., Y.K.); Department of the Cardiovascular System, Fukuoka Children\u2019s Hospital and Medical Center for Infectious Diseases, Fukuoka, Japan (H.U.); Department of Pediatrics, Niigata City General Hospital, Niigata, Japan (S.S.); Department of Rehabilitation, Aichi Saiseikai Rehabilitation Hospital, Nagoya, Japan (N.T., M.N.); Departments of Child Health (H.H.) and Epidemiology (H.T.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Horigome","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan (M.Y., Y.K.); Department of the Cardiovascular System, Fukuoka Children\u2019s Hospital and Medical Center for Infectious Diseases, Fukuoka, Japan (H.U.); Department of Pediatrics, Niigata City General Hospital, Niigata, Japan (S.S.); Department of Rehabilitation, Aichi Saiseikai Rehabilitation Hospital, Nagoya, Japan (N.T., M.N.); Departments of Child Health (H.H.) and Epidemiology (H.T.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Takahashi","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan (M.Y., Y.K.); Department of the Cardiovascular System, Fukuoka Children\u2019s Hospital and Medical Center for Infectious Diseases, Fukuoka, Japan (H.U.); Department of Pediatrics, Niigata City General Hospital, Niigata, Japan (S.S.); Department of Rehabilitation, Aichi Saiseikai Rehabilitation Hospital, Nagoya, Japan (N.T., M.N.); Departments of Child Health (H.H.) and Epidemiology (H.T.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naokata","family":"Sumitomo","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan (M.Y., Y.K.); Department of the Cardiovascular System, Fukuoka Children\u2019s Hospital and Medical Center for Infectious Diseases, Fukuoka, Japan (H.U.); Department of Pediatrics, Niigata City General Hospital, Niigata, Japan (S.S.); Department of Rehabilitation, Aichi Saiseikai Rehabilitation Hospital, Nagoya, Japan (N.T., M.N.); Departments of Child Health (H.H.) and Epidemiology (H.T.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuu","family":"Kucho","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan (M.Y., Y.K.); Department of the Cardiovascular System, Fukuoka Children\u2019s Hospital and Medical Center for Infectious Diseases, Fukuoka, Japan (H.U.); Department of Pediatrics, Niigata City General Hospital, Niigata, Japan (S.S.); Department of Rehabilitation, Aichi Saiseikai Rehabilitation Hospital, Nagoya, Japan (N.T., M.N.); Departments of Child Health (H.H.) and Epidemiology (H.T.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan (M.Y., Y.K.); Department of the Cardiovascular System, Fukuoka Children\u2019s Hospital and Medical Center for Infectious Diseases, Fukuoka, Japan (H.U.); Department of Pediatrics, Niigata City General Hospital, Niigata, Japan (S.S.); Department of Rehabilitation, Aichi Saiseikai Rehabilitation Hospital, Nagoya, Japan (N.T., M.N.); Departments of Child Health (H.H.) and Epidemiology (H.T.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Nomura","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan (M.Y., Y.K.); Department of the Cardiovascular System, Fukuoka Children\u2019s Hospital and Medical Center for Infectious Diseases, Fukuoka, Japan (H.U.); Department of Pediatrics, Niigata City General Hospital, Niigata, Japan (S.S.); Department of Rehabilitation, Aichi Saiseikai Rehabilitation Hospital, Nagoya, Japan (N.T., M.N.); Departments of Child Health (H.H.) and Epidemiology (H.T.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan (M.Y., Y.K.); Department of the Cardiovascular System, Fukuoka Children\u2019s Hospital and Medical Center for Infectious Diseases, Fukuoka, Japan (H.U.); Department of Pediatrics, Niigata City General Hospital, Niigata, Japan (S.S.); Department of Rehabilitation, Aichi Saiseikai Rehabilitation Hospital, Nagoya, Japan (N.T., M.N.); Departments of Child Health (H.H.) and Epidemiology (H.T.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Nagashima","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan (M.Y., Y.K.); Department of the Cardiovascular System, Fukuoka Children\u2019s Hospital and Medical Center for Infectious Diseases, Fukuoka, Japan (H.U.); Department of Pediatrics, Niigata City General Hospital, Niigata, Japan (S.S.); Department of Rehabilitation, Aichi Saiseikai Rehabilitation Hospital, Nagoya, Japan (N.T., M.N.); Departments of Child Health (H.H.) and Epidemiology (H.T.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.962019"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-08-0947"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.05.029"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.5.e64"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.158.4.359"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj117"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.4.677"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.658021"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181841eca"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806113382401"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.66.3.496"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1880-4276(11)80044-X"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.863209"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.2.782"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00408.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.6.3.378"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.109.882159"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80781-4"},{"key":"e_1_3_3_20_2","unstructured":"ICH Q14. http:\/\/www.ich.org\/products\/guidelines\/efficacy\/article\/efficacyguidelines.html. Accessed July 13 2013."},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-08-0995"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.4137\/CMC.S5933"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl115"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl415"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0643"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.056"}],"container-title":["Circulation: Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.113.000619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:05:34Z","timestamp":1715558734000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.113.000619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1161\/CIRCEP.113.000619"],"URL":"https:\/\/doi.org\/10.1161\/circep.113.000619","relation":{},"ISSN":["1941-3149","1941-3084"],"issn-type":[{"value":"1941-3149","type":"print"},{"value":"1941-3084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"2012-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}