{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:03:43Z","timestamp":1776866623897,"version":"3.51.2"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The role of subsequent atrial tachycardias (AT) in the context of persistent atrial fibrillation (AF) remains undetermined. This study evaluated the prognostic role of subsequent ATs for arrhythmia recurrences after catheter ablation of persistent AF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              A total of 110 patients with persistent AF (63\u00b19 years; 22 women; 61 long-lasting persistent AF) underwent pulmonary vein isolation followed by electrogram-guided ablation. After AF terminated to AT, patients were separated by the randomization protocol to receive either direct cardioversion (group A) or further ablation of subsequent ATs to sinus rhythm (group B). After a mean follow-up of 20.1\u00b113.3 months after the first procedure, significantly more group B patients were in sinus rhythm as compared with patients in group A (30 [57%] versus 18 [34%];\n              <jats:italic>P<\/jats:italic>\n              =0.02). Moreover, recurrences of AF were significantly less frequent of group B than in group A patients (10 [19%] versus 26 [49%];\n              <jats:italic>P<\/jats:italic>\n              =0.001). After the last procedure (follow-up, 34.0\u00b16.4 months), significantly more group B patients were free of AF as compared with patients of group A (49 [92%] versus 39 [74%];\n              <jats:italic>P<\/jats:italic>\n              =0.01). The proportion of AT recurrences did not differ between the 2 groups after the first and final procedures. The strongest predictor for an arrhythmia-free survival after a single procedure was randomization to the procedural end point of termination to sinus rhythm by elimination of subsequent ATs (\n              <jats:italic>P<\/jats:italic>\n              =0.004).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Catheter ablation of subsequent ATs increases freedom from AF but not AT, suggesting a contributing role of subsequent ATs in the mechanisms of persistent AF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT01896570.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.113.001019","type":"journal-article","created":{"date-parts":[[2013,10,26]],"date-time":"2013-10-26T01:51:41Z","timestamp":1382752301000},"page":"1059-1065","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Prognostic Role of Subsequent Atrial Tachycardias Occurring During Ablation of Persistent Atrial Fibrillation"],"prefix":"10.1161","volume":"6","author":[{"given":"Thomas","family":"Rostock","sequence":"first","affiliation":[{"name":"From the II. Medical Clinic, Department of Electrophysiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany (T.R., C.T., K.B.); Department of Electrophysiology, University Hospital Eppendorf, University Heart Center, Hamburg, Germany (T.R., T.V.S., B.A.H., D.S., I.B., K.M., C.T., K.B., H.S., A.S., S.W.); and Royal Brompton Hospital, Royal Brompton and Harefield NHS Foundation Trust and National Heart Lung Institute, Imperial College London, London, United Kingdom (T.V.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tushar V.","family":"Salukhe","sequence":"additional","affiliation":[{"name":"From the II. Medical Clinic, Department of Electrophysiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany (T.R., C.T., K.B.); Department of Electrophysiology, University Hospital Eppendorf, University Heart Center, Hamburg, Germany (T.R., T.V.S., B.A.H., D.S., I.B., K.M., C.T., K.B., H.S., A.S., S.W.); and Royal Brompton Hospital, Royal Brompton and Harefield NHS Foundation Trust and National Heart Lung Institute, Imperial College London, London, United Kingdom (T.V.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris A.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"From the II. Medical Clinic, Department of Electrophysiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany (T.R., C.T., K.B.); Department of Electrophysiology, University Hospital Eppendorf, University Heart Center, Hamburg, Germany (T.R., T.V.S., B.A.H., D.S., I.B., K.M., C.T., K.B., H.S., A.S., S.W.); and Royal Brompton Hospital, Royal Brompton and Harefield NHS Foundation Trust and National Heart Lung Institute, Imperial College London, London, United Kingdom (T.V.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Steven","sequence":"additional","affiliation":[{"name":"From the II. Medical Clinic, Department of Electrophysiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany (T.R., C.T., K.B.); Department of Electrophysiology, University Hospital Eppendorf, University Heart Center, Hamburg, Germany (T.R., T.V.S., B.A.H., D.S., I.B., K.M., C.T., K.B., H.S., A.S., S.W.); and Royal Brompton Hospital, Royal Brompton and Harefield NHS Foundation Trust and National Heart Lung Institute, Imperial College London, London, United Kingdom (T.V.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imke","family":"Berner","sequence":"additional","affiliation":[{"name":"From the II. Medical Clinic, Department of Electrophysiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany (T.R., C.T., K.B.); Department of Electrophysiology, University Hospital Eppendorf, University Heart Center, Hamburg, Germany (T.R., T.V.S., B.A.H., D.S., I.B., K.M., C.T., K.B., H.S., A.S., S.W.); and Royal Brompton Hospital, Royal Brompton and Harefield NHS Foundation Trust and National Heart Lung Institute, Imperial College London, London, United Kingdom (T.V.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"M\u00fcllerleile","sequence":"additional","affiliation":[{"name":"From the II. Medical Clinic, Department of Electrophysiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany (T.R., C.T., K.B.); Department of Electrophysiology, University Hospital Eppendorf, University Heart Center, Hamburg, Germany (T.R., T.V.S., B.A.H., D.S., I.B., K.M., C.T., K.B., H.S., A.S., S.W.); and Royal Brompton Hospital, Royal Brompton and Harefield NHS Foundation Trust and National Heart Lung Institute, Imperial College London, London, United Kingdom (T.V.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathrin","family":"Theis","sequence":"additional","affiliation":[{"name":"From the II. Medical Clinic, Department of Electrophysiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany (T.R., C.T., K.B.); Department of Electrophysiology, University Hospital Eppendorf, University Heart Center, Hamburg, Germany (T.R., T.V.S., B.A.H., D.S., I.B., K.M., C.T., K.B., H.S., A.S., S.W.); and Royal Brompton Hospital, Royal Brompton and Harefield NHS Foundation Trust and National Heart Lung Institute, Imperial College London, London, United Kingdom (T.V.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Bock","sequence":"additional","affiliation":[{"name":"From the II. Medical Clinic, Department of Electrophysiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany (T.R., C.T., K.B.); Department of Electrophysiology, University Hospital Eppendorf, University Heart Center, Hamburg, Germany (T.R., T.V.S., B.A.H., D.S., I.B., K.M., C.T., K.B., H.S., A.S., S.W.); and Royal Brompton Hospital, Royal Brompton and Harefield NHS Foundation Trust and National Heart Lung Institute, Imperial College London, London, United Kingdom (T.V.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helge","family":"Servatius","sequence":"additional","affiliation":[{"name":"From the II. Medical Clinic, Department of Electrophysiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany (T.R., C.T., K.B.); Department of Electrophysiology, University Hospital Eppendorf, University Heart Center, Hamburg, Germany (T.R., T.V.S., B.A.H., D.S., I.B., K.M., C.T., K.B., H.S., A.S., S.W.); and Royal Brompton Hospital, Royal Brompton and Harefield NHS Foundation Trust and National Heart Lung Institute, Imperial College London, London, United Kingdom (T.V.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arian","family":"Sultan","sequence":"additional","affiliation":[{"name":"From the II. Medical Clinic, Department of Electrophysiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany (T.R., C.T., K.B.); Department of Electrophysiology, University Hospital Eppendorf, University Heart Center, Hamburg, Germany (T.R., T.V.S., B.A.H., D.S., I.B., K.M., C.T., K.B., H.S., A.S., S.W.); and Royal Brompton Hospital, Royal Brompton and Harefield NHS Foundation Trust and National Heart Lung Institute, Imperial College London, London, United Kingdom (T.V.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Willems","sequence":"additional","affiliation":[{"name":"From the II. Medical Clinic, Department of Electrophysiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany (T.R., C.T., K.B.); Department of Electrophysiology, University Hospital Eppendorf, University Heart Center, Hamburg, Germany (T.R., T.V.S., B.A.H., D.S., I.B., K.M., C.T., K.B., H.S., A.S., S.W.); and Royal Brompton Hospital, Royal Brompton and Harefield NHS Foundation Trust and National Heart Lung Institute, Imperial College London, London, United Kingdom (T.V.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.00308.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.054"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.108.772392"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.01.017"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.107.748160"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.899021"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.04.060"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.111.966226"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.04.012"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2005.50002.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.09.031"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.05.040"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eum208"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01373.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.04.028"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.00307.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.05.008"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.05.022"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12075"},{"issue":"75","key":"e_1_3_3_21_2","first-page":"AB33","article-title":"Targeted ablation of persistent AF guided by noninvasive panoramic AF mapping.","volume":"10","author":"Haissaguerre M","year":"2013","unstructured":"Haissaguerre M, Dubois R, Shah A, Ramoul K, Komatsu Y, Daly M, Zellerhoff S, Denis A, Derval N, Sacher F, Jesel L, Bernus O, Jais P, Hocini M. 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