{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:53:36Z","timestamp":1791726816661,"version":"4.3.4"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Radiofrequency ablation inside pulmonary vein (PV) ostia can cause PV stenosis. A novel alternative method of ablation is irreversible electroporation, but the long-term response of PVs to electroporation ablation is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>In ten 6-month-old pigs (60\u201375 kg), the response of PVs to circular electroporation and radiofrequency ablation was compared. Ten consecutive, nonarcing, electroporation applications of 200 J were delivered 5 to 10 mm inside 1 of the 2 main PVs, using a custom-deflectable, 18-mm circular decapolar catheter. Inside the other PV, circular radiofrequency ablation was performed using 30 W radiofrequency applications via an irrigated 4-mm ablation catheter. PV angiograms were made before ablation, immediately after ablation, and after 3-month survival. PV diameters and heart size were measured. With electroporation ablation, PV ostial diameter decreased 11\u00b110% directly after ablation, but had increased 19\u00b111% after 3 months. With radiofrequency ablation, PV ostial diameter decreased 23\u00b115% directly after ablation and remained 7\u00b117% smaller after 3 months compared with preablation diameter despite a 21\u00b17% increase in heart size during aging from 6 to 9 months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In this porcine model, multiple circumferential 200-J electroporation applications inside the PV ostia do not affect PV diameter at 3-month follow-up. Radiofrequency ablation inside PV ostia causes considerable PV stenosis directly after ablation, which persists after 3 months.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.113.001111","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T04:15:47Z","timestamp":1403583347000},"page":"734-738","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":129,"title":["Pulmonary Vein Stenosis After Catheter Ablation"],"prefix":"10.1161","volume":"7","author":[{"given":"Vincent J.H.M.","family":"van Driel","sequence":"first","affiliation":[{"name":"From the Departments of Cardiology (V.J.H.M.v.D., K.G.E.J.N., H.v.W., B.C.d.P., P.A.F.M.D., F.H.M.W.) and Pathology (A.V.), University Medical Center, Utrecht, The Netherlands; and Department of Rhythmology, Alfried Krupp Hospital, Essen, Germany (K.G.E.J.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kars G.E.J.","family":"Neven","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.J.H.M.v.D., K.G.E.J.N., H.v.W., B.C.d.P., P.A.F.M.D., F.H.M.W.) and Pathology (A.V.), University Medical Center, Utrecht, The Netherlands; and Department of Rhythmology, Alfried Krupp Hospital, Essen, Germany (K.G.E.J.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"van Wessel","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.J.H.M.v.D., K.G.E.J.N., H.v.W., B.C.d.P., P.A.F.M.D., F.H.M.W.) and Pathology (A.V.), University Medical Center, Utrecht, The Netherlands; and Department of Rhythmology, Alfried Krupp Hospital, Essen, Germany (K.G.E.J.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastiaan C.","family":"du Pr\u00e9","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.J.H.M.v.D., K.G.E.J.N., H.v.W., B.C.d.P., P.A.F.M.D., F.H.M.W.) and Pathology (A.V.), University Medical Center, Utrecht, The Netherlands; and Department of Rhythmology, Alfried Krupp Hospital, Essen, Germany (K.G.E.J.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryan","family":"Vink","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.J.H.M.v.D., K.G.E.J.N., H.v.W., B.C.d.P., P.A.F.M.D., F.H.M.W.) and Pathology (A.V.), University Medical Center, Utrecht, The Netherlands; and Department of Rhythmology, Alfried Krupp Hospital, Essen, Germany (K.G.E.J.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter A.F.M.","family":"Doevendans","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.J.H.M.v.D., K.G.E.J.N., H.v.W., B.C.d.P., P.A.F.M.D., F.H.M.W.) and Pathology (A.V.), University Medical Center, Utrecht, The Netherlands; and Department of Rhythmology, Alfried Krupp Hospital, Essen, Germany (K.G.E.J.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred H.M.","family":"Wittkampf","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.J.H.M.v.D., K.G.E.J.N., H.v.W., B.C.d.P., P.A.F.M.D., F.H.M.W.) and Pathology (A.V.), University Medical Center, Utrecht, The Netherlands; and Department of Rhythmology, Alfried Krupp Hospital, Essen, Germany (K.G.E.J.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01863.x"},{"key":"e_1_3_3_3_2","volume-title":"Institute for Laboratory Animal Research: Guide for the Care and Use of Laboratory Animals","year":"2011","unstructured":"Institute for Laboratory Animal Research: Guide for the Care and Use of Laboratory Animals. 8th ed. 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