{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:55:23Z","timestamp":1792608923062,"version":"4.5.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>\n              We sought to compare left ventricular (LV\n              <jats:sub>epi<\/jats:sub>\n              ) and biventricular epicardial pacing (BIV\n              <jats:sub>epi<\/jats:sub>\n              ) with LV (LV\n              <jats:sub>endo<\/jats:sub>\n              ) and BIV endocardial pacing (BIV\n              <jats:sub>endo<\/jats:sub>\n              ) in patients with chronic heart failure with an emphasis on the underlying electrophysiological mechanisms and hemodynamic effects.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Ten patients with chronically implanted cardiac resynchronization devices underwent temporary LV\n              <jats:sub>endo<\/jats:sub>\n              and BIV\n              <jats:sub>endo<\/jats:sub>\n              pacing with an LV endocardial roving catheter. A pressure wire and noncontact mapping array were placed to the LV cavity to measure LVdP\/dt\n              <jats:sub>max<\/jats:sub>\n              and perform electroanatomical mapping. At the optimal endocardial position, the acute hemodynamic response (AHR) was superior to epicardial stimulation, the AHR to BIV\n              <jats:sub>endo<\/jats:sub>\n              pacing and LV\n              <jats:sub>endo<\/jats:sub>\n              pacing being comparable (21\u00b115% versus 22\u00b117%;\n              <jats:italic>P<\/jats:italic>\n              =NS). During intrinsic conduction, QRS duration was 185\u00b130 ms, endocardial LV total activation time 92\u00b127 ms, and trans-septal activation time 60\u00b121 ms. With LV\n              <jats:sub>endo<\/jats:sub>\n              pacing, QRS duration (187\u00b129 ms;\n              <jats:italic>P<\/jats:italic>\n              =NS) and endocardial LV total activation time (91\u00b123 ms;\n              <jats:italic>P<\/jats:italic>\n              =NS) were comparable with intrinsic conduction. There was no significant difference in endocardial LV total activation time between LV\n              <jats:sub>endo<\/jats:sub>\n              and BIV\n              <jats:sub>endo<\/jats:sub>\n              pacing (91\u00b123 versus 85\u00b115 ms;\n              <jats:italic>P<\/jats:italic>\n              =NS). Assessment of isochronal maps identified slow trans-septal conduction with both LV\n              <jats:sub>endo<\/jats:sub>\n              and BIV\n              <jats:sub>endo<\/jats:sub>\n              pacing resulting in activation of almost the entire LV endocardium prior to septal breakout, thereby limiting any possible fusion with either pacing mode.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              The equivalent AHR to LV\n              <jats:sub>endo<\/jats:sub>\n              and BIV\n              <jats:sub>endo<\/jats:sub>\n              pacing may be explained by prolonged trans-septal conduction limiting fusion of electrical wavefronts. The optimal AHR was associated with predominantly LV pre-excitation and depolarization. Our results suggest that LV pacing alone may offer a viable endocardial stimulation strategy to achieve cardiac resynchronization.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.113.001152","type":"journal-article","created":{"date-parts":[[2014,3,8]],"date-time":"2014-03-08T05:18:15Z","timestamp":1394255895000},"page":"251-258","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Delayed Trans-Septal Activation Results in Comparable Hemodynamic Effect of Left Ventricular and Biventricular Endocardial Pacing"],"prefix":"10.1161","volume":"7","author":[{"given":"Manav","family":"Sohal","sequence":"first","affiliation":[{"name":"From the Division of Imaging Sciences and Biomedical Engineering, King\u2019s College, London, United Kingdom (M.S., A.S., S.N., Z.C., T.J., E.S., R.R., C.A.R.); Cardiovascular Department, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom (M.S., A.S., J.B., C.A.R.); and Maastricht University Medical Center, Cardiovascular Research Institute (CARIM), Maastricht, the Netherlands (F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop","family":"Shetty","sequence":"additional","affiliation":[{"name":"From the Division of Imaging Sciences and Biomedical Engineering, King\u2019s College, London, United Kingdom (M.S., A.S., S.N., Z.C., T.J., E.S., R.R., C.A.R.); Cardiovascular Department, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom (M.S., A.S., J.B., C.A.R.); and Maastricht University Medical Center, Cardiovascular Research Institute (CARIM), Maastricht, the Netherlands (F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Niederer","sequence":"additional","affiliation":[{"name":"From the Division of Imaging Sciences and Biomedical Engineering, King\u2019s College, London, United Kingdom (M.S., A.S., S.N., Z.C., T.J., E.S., R.R., C.A.R.); Cardiovascular Department, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom (M.S., A.S., J.B., C.A.R.); and Maastricht University Medical Center, Cardiovascular Research Institute (CARIM), Maastricht, the Netherlands (F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Division of Imaging Sciences and Biomedical Engineering, King\u2019s College, London, United Kingdom (M.S., A.S., S.N., Z.C., T.J., E.S., R.R., C.A.R.); Cardiovascular Department, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom (M.S., A.S., J.B., C.A.R.); and Maastricht University Medical Center, Cardiovascular Research Institute (CARIM), Maastricht, the Netherlands (F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Jackson","sequence":"additional","affiliation":[{"name":"From the Division of Imaging Sciences and Biomedical Engineering, King\u2019s College, London, United Kingdom (M.S., A.S., S.N., Z.C., T.J., E.S., R.R., C.A.R.); Cardiovascular Department, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom (M.S., A.S., J.B., C.A.R.); and Maastricht University Medical Center, Cardiovascular Research Institute (CARIM), Maastricht, the Netherlands (F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Sammut","sequence":"additional","affiliation":[{"name":"From the Division of Imaging Sciences and Biomedical Engineering, King\u2019s College, London, United Kingdom (M.S., A.S., S.N., Z.C., T.J., E.S., R.R., C.A.R.); Cardiovascular Department, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom (M.S., A.S., J.B., C.A.R.); and Maastricht University Medical Center, Cardiovascular Research Institute (CARIM), Maastricht, the Netherlands (F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Bostock","sequence":"additional","affiliation":[{"name":"From the Division of Imaging Sciences and Biomedical Engineering, King\u2019s College, London, United Kingdom (M.S., A.S., S.N., Z.C., T.J., E.S., R.R., C.A.R.); Cardiovascular Department, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom (M.S., A.S., J.B., C.A.R.); and Maastricht University Medical Center, Cardiovascular Research Institute (CARIM), Maastricht, the Netherlands (F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Razavi","sequence":"additional","affiliation":[{"name":"From the Division of Imaging Sciences and Biomedical Engineering, King\u2019s College, London, United Kingdom (M.S., A.S., S.N., Z.C., T.J., E.S., R.R., C.A.R.); Cardiovascular Department, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom (M.S., A.S., J.B., C.A.R.); and Maastricht University Medical Center, Cardiovascular Research Institute (CARIM), Maastricht, the Netherlands (F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits","family":"Prinzen","sequence":"additional","affiliation":[{"name":"From the Division of Imaging Sciences and Biomedical Engineering, King\u2019s College, London, United Kingdom (M.S., A.S., S.N., Z.C., T.J., E.S., R.R., C.A.R.); Cardiovascular Department, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom (M.S., A.S., J.B., C.A.R.); and Maastricht University Medical Center, Cardiovascular Research Institute (CARIM), Maastricht, the Netherlands (F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Aldo","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"From the Division of Imaging Sciences and Biomedical Engineering, King\u2019s College, London, United Kingdom (M.S., A.S., S.N., Z.C., T.J., E.S., R.R., C.A.R.); Cardiovascular Department, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom (M.S., A.S., J.B., C.A.R.); and Maastricht University Medical Center, Cardiovascular Research Institute (CARIM), Maastricht, the Netherlands (F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.10.032"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.743120"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.032904"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.111.000028"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.111.970277"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.08.045"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.110.958124"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01892-6"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.108.846022"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01117.2011"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.111.967505"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2008.01042.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2009.00878.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.02.061"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.098"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2011.03268.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.04.042"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.9.887"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000118502.91105.F6"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.965814"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.10.3273"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01648-5"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.634444"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.23.2993"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.000646"}],"container-title":["Circulation: Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.113.001152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:05:50Z","timestamp":1715558750000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.113.001152"}},"subtitle":["Insights From Electroanatomical Mapping"],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1161\/CIRCEP.113.001152"],"URL":"https:\/\/doi.org\/10.1161\/circep.113.001152","relation":{},"ISSN":["1941-3149","1941-3084"],"issn-type":[{"value":"1941-3149","type":"print"},{"value":"1941-3084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"2013-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}