{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:24:21Z","timestamp":1793730261586,"version":"4.6.1"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The use of second-generation cryoballoon for pulmonary vein isolation in patients with paroxysmal atrial fibrillation has demonstrated encouraging acute and mid-term results. Long-term outcome data are not yet available.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>Fifty patients (18 women; mean age, 61\u00b111 years; mean left atrial diameter, 43\u00b15 mm) with paroxysmal (36 of 50 patients; 72%) or short-standing (&lt;3-month duration) persistent atrial fibrillation (14 of 50 patients; 28%) underwent cryoballoon-based pulmonary vein isolation. Freeze cycle duration was 240 seconds. After successful pulmonary vein isolation, a bonus freeze was applied. Follow-up was based on outpatient clinic visits at 3, 6, and 12 months including Holter-ECGs and telephonic interviews. Recurrence was defined as a symptomatic or documented arrhythmia episode &gt;30 seconds excluding a 3-month blanking period. A total of 192 pulmonary veins were identified, and 191 of 192 (99%) pulmonary veins were successfully isolated. Phrenic nerve palsy occurred in 1 of 50 (2%) patients. Follow-up was available for 49 of 50 (98%) patients with a mean follow-up duration of 440\u00b139 days. Thirty-nine of 49 (80%) patients remained in stable sinus rhythm. Of 8 of 10 patients with arrhythmia recurrence, a second procedure using radiofrequency ablation demonstrated left atrial to pulmonary vein reconduction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The use of second-generation 28-mm cryoballoon for pulmonary vein isolation results in an 80% 1-year success rate.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.114.001473","type":"journal-article","created":{"date-parts":[[2014,3,9]],"date-time":"2014-03-09T01:54:50Z","timestamp":1394330090000},"page":"288-292","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":188,"title":["One-Year Clinical Outcome After Pulmonary Vein Isolation Using the Second-Generation 28-mm Cryoballoon"],"prefix":"10.1161","volume":"7","author":[{"given":"Andreas","family":"Metzner","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, AsklepiosKlinik St Georg, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Reissmann","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, AsklepiosKlinik St Georg, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rausch","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, AsklepiosKlinik St Georg, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibu","family":"Mathew","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, AsklepiosKlinik St Georg, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wohlmuth","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, AsklepiosKlinik St Georg, Hamburg, 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