{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:56:54Z","timestamp":1770339414448,"version":"3.49.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Radiofrequency catheter ablation (RFCA) of ventricular tachycardia (VT) in repaired Tetralogy of Fallot focuses on isthmuses in the right ventricle but may be hampered by hypertrophied myocardium or prosthetic material. These patients may benefit from ablation at the left side of the ventricular septum.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>Records from 28 consecutive repaired Tetralogy of Fallot patients from 2 centers who underwent VT ablation were reviewed. Ablation targeted anatomic isthmuses containing VT re-entry circuits, which were identified by 3-dimensional substrate, pace, and entrainment mapping. A left-sided approach was considered beneficial if (1) right-sided RFCA failed, (2) part of the circuit was mapped to the left side, and (3) left-sided RFCA resulted in isthmus transection and prevention of VT induction. In 4 of 28 patients (52\u00b113 years; 75% men), inducible for 1.5 (quartiles, 1.0 \u2013 2.0) VTs (335\u00b158 ms), left-sided RFCA was performed. In 3 patients, RFCA at aortic sites terminated VT related to a septal isthmus and prevented reinduction. In 1 patient, with prior biventricular implantable cardioverter-defibrillator, diastolic activity was recorded at the left side of the septum in proximity to the His-bundle. RFCA prevented VT reinduction with anticipated complete atrioventricular block. The left-sided approach resulted in complete procedural success (transection of anatomic isthmus and noninducibility) and freedom of VT recurrence during follow-up (20\u00b115 months) in all patients. Right-sided RFCA failure was likely because of septal hypertrophy in 2, overlying pulmonary homograft in 1, and overlying ventricular septal defect patch in 1.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Left-sided RFCA for VTs dependent on septal anatomic isthmuses improves ablation outcome in repaired Tetralogy of Fallot.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.114.001661","type":"journal-article","created":{"date-parts":[[2014,8,24]],"date-time":"2014-08-24T00:45:23Z","timestamp":1408841123000},"page":"889-897","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Left-Sided Ablation of Ventricular Tachycardia in Adults With Repaired Tetralogy of Fallot"],"prefix":"10.1161","volume":"7","author":[{"given":"Gijsbert F.L.","family":"Kapel","sequence":"first","affiliation":[{"name":"From the Departments of Cardiology, Cardiac Surgery and Anatomy, Leiden University Medical Centre, Leiden, The Netherlands (G.F.L.K., A.P.W., S.R.D.P., M.J.S., M.G.H., M.R.M.J., K.Z.); and Department of Cardiology, Brigham and Women\u2019s Hospital, Boston, MA (T.R., U.B.T., W.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Reichlin","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology, Cardiac Surgery and Anatomy, Leiden University Medical Centre, Leiden, The Netherlands (G.F.L.K., A.P.W., S.R.D.P., M.J.S., M.G.H., M.R.M.J., K.Z.); and Department of Cardiology, Brigham and Women\u2019s Hospital, Boston, MA (T.R., U.B.T., W.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrianus P.","family":"Wijnmaalen","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology, Cardiac Surgery and Anatomy, Leiden University Medical Centre, Leiden, The Netherlands (G.F.L.K., A.P.W., S.R.D.P., M.J.S., M.G.H., M.R.M.J., K.Z.); and Department of Cardiology, Brigham and Women\u2019s Hospital, Boston, MA (T.R., U.B.T., W.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usha B.","family":"Tedrow","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology, Cardiac Surgery and Anatomy, Leiden University Medical Centre, Leiden, The Netherlands (G.F.L.K., A.P.W., S.R.D.P., M.J.S., M.G.H., M.R.M.J., K.Z.); and Department of Cardiology, Brigham and Women\u2019s Hospital, Boston, MA (T.R., U.B.T., W.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiaan R.D.","family":"Piers","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology, Cardiac Surgery and Anatomy, Leiden University Medical Centre, Leiden, The Netherlands (G.F.L.K., A.P.W., S.R.D.P., M.J.S., M.G.H., M.R.M.J., K.Z.); and Department of Cardiology, Brigham and Women\u2019s Hospital, Boston, MA (T.R., U.B.T., W.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.","family":"Schalij","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology, Cardiac Surgery and Anatomy, Leiden University Medical Centre, Leiden, The Netherlands (G.F.L.K., A.P.W., S.R.D.P., M.J.S., M.G.H., M.R.M.J., K.Z.); and Department of Cardiology, Brigham and Women\u2019s Hospital, Boston, MA (T.R., U.B.T., W.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark G.","family":"Hazekamp","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology, Cardiac Surgery and Anatomy, Leiden University Medical Centre, Leiden, The Netherlands (G.F.L.K., A.P.W., S.R.D.P., M.J.S., M.G.H., M.R.M.J., K.Z.); and Department of Cardiology, Brigham and Women\u2019s Hospital, Boston, MA (T.R., U.B.T., W.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique R.M.","family":"Jongbloed","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology, Cardiac Surgery and Anatomy, Leiden University Medical Centre, Leiden, The Netherlands (G.F.L.K., A.P.W., S.R.D.P., M.J.S., M.G.H., M.R.M.J., K.Z.); and Department of Cardiology, Brigham and Women\u2019s Hospital, Boston, MA (T.R., U.B.T., W.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology, Cardiac Surgery and Anatomy, Leiden University Medical Centre, Leiden, The Netherlands (G.F.L.K., A.P.W., S.R.D.P., M.J.S., M.G.H., M.R.M.J., K.Z.); and Department of Cardiology, Brigham and Women\u2019s Hospital, Boston, MA (T.R., U.B.T., W.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Zeppenfeld","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology, Cardiac Surgery and Anatomy, Leiden University Medical Centre, Leiden, The Netherlands (G.F.L.K., A.P.W., S.R.D.P., M.J.S., M.G.H., M.R.M.J., K.Z.); and Department of Cardiology, Brigham and Women\u2019s Hospital, Boston, MA (T.R., U.B.T., W.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.627224"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq032"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.726372"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.723551"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.03.009"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.9.272"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000030187.39852.a7"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00065-X"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.13.1517"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(91)90329-N"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(88)90100-3"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.04.001"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)65615-9"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq249"}],"container-title":["Circulation: Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.114.001661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:53:29Z","timestamp":1715558009000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.114.001661"}},"subtitle":["A Case Series"],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1161\/CIRCEP.114.001661"],"URL":"https:\/\/doi.org\/10.1161\/circep.114.001661","relation":{},"ISSN":["1941-3149","1941-3084"],"issn-type":[{"value":"1941-3149","type":"print"},{"value":"1941-3084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"2014-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}