{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:44:08Z","timestamp":1765485848807},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The resynchronization-defibrillation for ambulatory heart failure trial (RAFT) study demonstrated that adding cardiac resynchronization therapy (CRT) in selected patients requiring de novo implantable cardiac defibrillators (ICD) reduced mortality as compared with ICD therapy alone, despite an increase in procedure-related adverse events. Data are lacking regarding the management of patients with ICD therapy who develop an indication for CRT upgrade.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Participating RAFT centers provided data regarding de novo CRT-D (CRT with ICD) implant, upgrade to CRT-D during RAFT (study upgrade), and upgrade within 6 months after presentation of study results (substudy). Substudy centers enrolled 1346 (74.9%) patients in RAFT, including 644 de novo, 80 study upgrade, and 60 substudy CRT attempts. The success rate (initial plus repeat attempts) was 95.2% for de novo versus 96.3% for study upgrade and 90.0% for substudy CRT attempts (\n              <jats:italic>P<\/jats:italic>\n              =0.402). Acute complications occurred among 26.2% of de novo versus 18.8% of study upgrade and 3.4% of substudy CRT implantation attempts (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The most common complication was left ventricular lead dislodgement. The principal reasons for not yet attempting upgrade in the substudy were patient preference (31.9%), New York Heart Association Class I (17.0%), and a QRS &lt;150 ms (13.1%).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Among a broad group of implant physicians, CRT upgrades were performed in patients with an ICD in situ with no difference in implant success rate and a reduced acute complication rate as compared with a de novo CRT implant. Decisions to upgrade were influenced by predictors of benefit in subgroup analyses of the RAFT study and other trials.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.114.001997","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T01:19:07Z","timestamp":1416791947000},"page":"152-158","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Incidence, Predictors, and Procedural Results of Upgrade to Resynchronization Therapy"],"prefix":"10.1161","volume":"8","author":[{"given":"Vidal","family":"Essebag","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Joza","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Birnie","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Sapp","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence D.","family":"Sterns","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Philippon","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Yee","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Crystal","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Kus","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Rinne","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Healey","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdi","family":"Sami","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Thibault","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek V.","family":"Exner","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit","family":"Coutu","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris S.","family":"Simpson","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B., E.Y., G.W., A.S.L.T.); Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (J.L.S.); Division of Cardiology, Victoria Cardiac Arrhythmia Trials, Victoria, BC, Canada (L.D.S.); Division of Cardiology, Quebec Heart and Lung Institute, Quebec City, QC, Canada (F.P...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaev","family":"Wulffhart","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (V.E., J.J., M.S.); 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