{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T16:50:23Z","timestamp":1767372623071},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Endovascularly implanted leads risk vascular injury and endocarditis, and can be difficult to locate in desired positions for LV pacing. We evaluated the acute and long-term stability, electric performance and histopathology of a percutaneously placed intrapericardial lead (IPL).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Twelve adult mongrel dogs underwent defibrillator implants incorporating IPLs. Successful uncomplicated percutaneous implantation of an IPL was achieved in all. Early fluoroscopic shift noted with 3 of 6 of the initial version IPL-1 was not seen with the modified IPL-2. Mean\u00b195% confidence interval bipolar capture threshold at 0.5-ms pulse width for the IPL increased from 0.69\u00b10.14 V at implant to 1.50\u00b10.34 V (\n              <jats:italic>P<\/jats:italic>\n              =0.003) at 12 weeks. The 12-week thresholds were higher for IPL compared with right ventricular endocardial leads (0.75\u00b10.33 V;\n              <jats:italic>P<\/jats:italic>\n              =0.001) but not different compared with coronary sinus leads (1.33\u00b10.58 V;\n              <jats:italic>P<\/jats:italic>\n              =0.994). IPL impedance increased from 742\u00b146 \u03a9 at implant to 1066\u00b1207 \u03a9 at 12 weeks (\n              <jats:italic>P<\/jats:italic>\n              =0.007). R-wave amplitude at 12 weeks was 8.37\u00b11.52 mV. There was no important phrenic nerve stimulation from IPL pacing. Histopathology in 8 animals showed adequate adhesion of the electrodes or mesh to the epicardium without damage to underlying vasculature. There was no evidence for late pericardial inflammation or effusion.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The IPL demonstrated adequate stability of position and acceptable electric parameters without chronic pericardial inflammation in this canine model and offers a potential alternative to endocardial pacing leads.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.114.002076","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T13:53:50Z","timestamp":1427896430000},"page":"659-666","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Acute and Chronic Performance Evaluation of a Novel Epicardial Pacing Lead Placed by Percutaneous Subxiphoid Approach in a Canine Model"],"prefix":"10.1161","volume":"8","author":[{"given":"Roy M.","family":"John","sequence":"first","affiliation":[{"name":"From the Brigham and Women\u2019s Hospital, Boston, MA (R.M.J.); St. Jude Medical, Inc, Sylmar, CA (K.M., M.E.B.); Charles River Laboratories, Frederick, MD (L.H.B.); and Haut-L\u00e9v\u00eaque Hospital, Pessac, Bordeaux, France (P.J.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Morgan","sequence":"additional","affiliation":[{"name":"From the Brigham and Women\u2019s Hospital, Boston, MA (R.M.J.); St. Jude Medical, Inc, Sylmar, CA (K.M., M.E.B.); Charles River Laboratories, Frederick, MD (L.H.B.); and Haut-L\u00e9v\u00eaque Hospital, Pessac, Bordeaux, France (P.J.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas H.","family":"Brennecke","sequence":"additional","affiliation":[{"name":"From the Brigham and Women\u2019s Hospital, Boston, MA (R.M.J.); St. Jude Medical, Inc, Sylmar, CA (K.M., M.E.B.); Charles River Laboratories, Frederick, MD (L.H.B.); and Haut-L\u00e9v\u00eaque Hospital, Pessac, Bordeaux, France (P.J.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Benser","sequence":"additional","affiliation":[{"name":"From the Brigham and Women\u2019s Hospital, Boston, MA (R.M.J.); St. Jude Medical, Inc, Sylmar, CA (K.M., M.E.B.); Charles River Laboratories, Frederick, MD (L.H.B.); and Haut-L\u00e9v\u00eaque Hospital, Pessac, Bordeaux, France (P.J.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Jais","sequence":"additional","affiliation":[{"name":"From the Brigham and Women\u2019s Hospital, Boston, MA (R.M.J.); St. Jude Medical, Inc, Sylmar, CA (K.M., M.E.B.); Charles River Laboratories, Frederick, MD (L.H.B.); and Haut-L\u00e9v\u00eaque Hospital, Pessac, Bordeaux, France (P.J.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909545"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.964676"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-011-0158-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.12.075"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.060327"},{"key":"e_1_3_2_7_2","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"Institute for Laboratory Animal Research","year":"2011","unstructured":"Institute for Laboratory Animal Research. 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