{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:00:34Z","timestamp":1780700434682,"version":"3.54.1"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The differences in ablation characteristics of freezing time and balloon size using second generation cryoballoon are still unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Twenty-six dogs underwent pulmonary vein (PV) isolation. Balloon and tissue temperatures (left atrial\u2013PV junction, phrenic nerve, and internal esophagus) were monitored. The ablation duration was randomized to either 3 or 4 minutes, which did not show significant differences in temperature profiles, PV isolation success rate, complications, or histological changes. Twenty dogs underwent cryoablation using 28-mm cryoballoon, 6 dogs were done using the 23-mm cryoballoon. Positioning of the 23-mm cryoballoon was more distal in the PV, which resulted in better PV occlusion. Temperature profiles showed lower temperatures in the 23-mm cryoballoon than in the 28-mm cryoballoon (inner balloon, median [range]: \u221251.5 [\u221266.0 to \u221231.0] versus \u221243.0 [\u221264.0 to \u221226.0]\u00b0C,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; balloon surface: \u221243.0 [\u221260.0 to \u221215.8] versus \u22126.5 [\u221246.2 to 28.9]\u00b0C,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; left atrial\u2013PV junction: \u22126.7 [\u221220.0 to 21.4] versus 15.8 [\u221214.4 to 35.1]\u00b0C,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and trended toward a higher PV isolation success rate in the 23-mm cryoballoon. Histologically, deeper extensions of ablative lesions into the PV were seen with 23-mm cryoballoon, and larger ablative lesions were seen in the left atrial antrum using 28-mm cryoballoon.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The efficacy of 3-minute ablation was not significantly different from 4-minute ablation in dogs. The 23-mm cryoballoon had a greater cooling effect than the 28-mm cryoballoon for small PVs, but showed narrower ablative lesions in the left atrial antrum.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.115.002725","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T03:47:56Z","timestamp":1434512876000},"page":"836-845","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Impact of Freezing Time and Balloon Size on the Thermodynamics and Isolation Efficacy During Pulmonary Vein Isolation Using the Second Generation Cryoballoon"],"prefix":"10.1161","volume":"8","author":[{"given":"Mitsuru","family":"Takami","sequence":"first","affiliation":[{"name":"From the Translational Interventional Electrophysiology Laboratory, Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Immo","family":"Lehmann","sequence":"additional","affiliation":[{"name":"From the Translational Interventional Electrophysiology Laboratory, Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juna","family":"Misiri","sequence":"additional","affiliation":[{"name":"From the Translational Interventional Electrophysiology Laboratory, Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay D.","family":"Parker","sequence":"additional","affiliation":[{"name":"From the Translational Interventional Electrophysiology Laboratory, Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray I.","family":"Sarmiento","sequence":"additional","affiliation":[{"name":"From the Translational Interventional Electrophysiology Laboratory, Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan B.","family":"Johnson","sequence":"additional","affiliation":[{"name":"From the Translational Interventional Electrophysiology Laboratory, Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas L.","family":"Packer","sequence":"additional","affiliation":[{"name":"From the Translational Interventional Electrophysiology Laboratory, Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000899"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.01.002"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12114"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-014-9942-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12082"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1997.01430250030005"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2009.10.001"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01162.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.002137"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1999.tb00353.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu331"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.690578"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00887.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2006.11.004"}],"container-title":["Circulation: Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.115.002725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:45:21Z","timestamp":1715557521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.115.002725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1161\/CIRCEP.115.002725"],"URL":"https:\/\/doi.org\/10.1161\/circep.115.002725","relation":{},"ISSN":["1941-3149","1941-3084"],"issn-type":[{"value":"1941-3149","type":"print"},{"value":"1941-3084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"2015-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}