{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:38:35Z","timestamp":1783442315578,"version":"3.54.6"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Nonsustained ventricular tachycardia (NSVT) is common after acute coronary syndrome (ACS) and a marker of increased risk of arrhythmogenic death. However, the prognostic significance of NSVT when evaluated with other contemporary risk markers and at later time points after ACS remains uncertain.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              In the Platelet Inhibition and Patient Outcomes (PLATO) trial, continuous ECGs were performed during the first 7 days after ACS (n=2866) and repeated for another 7 days at day 30 (n=1991). Median follow-up was 1 year. There was a time-varying interaction between NSVT and cardiovascular death such that NSVT was significantly associated with increased risk within the first 30 days after randomization (22\/999 [2.2%] versus 16\/1825 [0.9%]; adjusted hazard ratio, 2.84; 95% confidence interval, 1.39\u20135.79;\n              <jats:italic>P<\/jats:italic>\n              =0.004) but not after 30 days (28\/929 [3.0%] versus 42\/1734 [2.4%];\n              <jats:italic>P<\/jats:italic>\n              =0.71). Detection of NSVT during the convalescent phase (n=428\/1991; 21.5%) was also associated with an increased risk of cardiovascular death, and was most marked within the first 2 months after detection (1.9% versus 0.3%; adjusted hazard ratio, 5.48; 95% confidence interval, 1.07\u201328.20;\n              <jats:italic>P<\/jats:italic>\n              =0.01), and then decreasing over time such that the relationship was no longer significant by \u22485 months after ACS.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>NSVT occurred frequently during the acute and convalescent phases of ACS. The risk of cardiovascular death associated with NSVT was the greatest during the first 30 days after presentation; however, patients with NSVT detected during the convalescent phase were also at a significantly increased risk of cardiovascular death that persisted for an additional several months after the index event.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00391872.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.115.002951","type":"journal-article","created":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T04:24:33Z","timestamp":1453782273000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Relationship Between Early and Late Nonsustained Ventricular Tachycardia and Cardiovascular Death in Patients With Acute Coronary Syndrome in the Platelet Inhibition and Patient Outcomes (PLATO) Trial"],"prefix":"10.1161","volume":"9","author":[{"given":"An H.","family":"Bui","sequence":"first","affiliation":[{"name":"For the author affiliations, please see the Appendix section."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Cannon","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix section."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe Gabriel","family":"Steg","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix section."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Storey","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix section."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Husted","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix section."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Guo","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix section."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KyungAh","family":"Im","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix section."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan K.","family":"James","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix section."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.","family":"Michelson","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix section."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Himmelmann","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix section."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes","family":"Held","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix section."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Varenhorst","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix section."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Wallentin","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix section."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin M.","family":"Scirica","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix 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