{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:56:35Z","timestamp":1781769395962,"version":"3.54.5"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Electric left ventricular lead position, assessed by the electric delay from the beginning of the QRS complex to the local LV electrogram (QLV), was found in previous studies to be a strong predictor of short-term response to cardiac resynchronization therapy. We hypothesized that suboptimum electric position of the left ventricular lead is associated with an excess of heart failure events and mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We analyzed the clinical outcome of patients with left bundle branch block or intraventricular conduction delay treated with cardiac resynchronization therapy at our institution during 9 years. Baseline clinical characteristics, QLV\/QRS duration (QLV ratio) at cardiac resynchronization therapy implant, and data about heart failure hospitalization and mode of death were collected in 329 patients who were followed for a period of 3.3\u00b11.9 years. Of them, 83 were hospitalized for heart failure and 83 died. Event rates for all-cause mortality, cardiac mortality, noncardiac mortality, heart failure mortality, and sudden death were 25.2%, 14.9%, 10.3%, 12.2%, and 2.1%, respectively. Patients with a QLV ratio \u22640.70 had significantly worse event-free survival for all study end points\u2014hazard ratio, 1.6; 95% confidence interval, 1.0 to 2.4;\n              <jats:italic>P<\/jats:italic>\n              =0.05 for heart failure hospitalization; hazard ratio, 2.9; 95% confidence interval, 1.6 to 5.5;\n              <jats:italic>P<\/jats:italic>\n              =0.001 for heart failure mortality; hazard ratio, 1.8; 95% confidence interval, 1.1 to 2.7;\n              <jats:italic>P<\/jats:italic>\n              =0.01 for cardiac mortality; and hazard ratio, 2.1; 95% confidence interval, 1.2 to 3.7;\n              <jats:italic>P<\/jats:italic>\n              =0.01 for all-cause mortality. In multivariable analysis, QLV ratio \u22640.70 remained associated with all study end points.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Electric left ventricular lead position in cardiac resynchronization therapy patients was a significant predictor of heart failure hospitalization and mortality.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.115.003004","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T02:33:27Z","timestamp":1441334007000},"page":"1113-1121","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Left Ventricular Lead Electrical Delay Is a Predictor of Mortality in Patients With Cardiac Resynchronization Therapy"],"prefix":"10.1161","volume":"8","author":[{"given":"Tomas","family":"Roubicek","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Regional Hospital Liberec, Liberec, Czech Republic (T.R., P.K., P.N., J. Kupec, J. Sedlakova, J.C., J. Stros, R.P.); Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (D.W., J. Kautzner); and Institute of Health Studies, Technical University of Liberec, Liberec, Czech Republic (D.W., J. Kautzner, R.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wichterle","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Regional Hospital Liberec, Liberec, Czech Republic (T.R., P.K., P.N., J. Kupec, J. Sedlakova, J.C., J. Stros, R.P.); Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (D.W., J. Kautzner); and Institute of Health Studies, Technical University of Liberec, Liberec, Czech Republic (D.W., J. Kautzner, R.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Kucera","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Regional Hospital Liberec, Liberec, Czech Republic (T.R., P.K., P.N., J. Kupec, J. Sedlakova, J.C., J. Stros, R.P.); Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (D.W., J. Kautzner); and Institute of Health Studies, Technical University of Liberec, Liberec, Czech Republic (D.W., J. Kautzner, R.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Nedbal","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Regional Hospital Liberec, Liberec, Czech Republic (T.R., P.K., P.N., J. Kupec, J. Sedlakova, J.C., J. Stros, R.P.); Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (D.W., J. Kautzner); and Institute of Health Studies, Technical University of Liberec, Liberec, Czech Republic (D.W., J. Kautzner, R.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jindrich","family":"Kupec","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Regional Hospital Liberec, Liberec, Czech Republic (T.R., P.K., P.N., J. Kupec, J. Sedlakova, J.C., J. Stros, R.P.); Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (D.W., J. Kautzner); and Institute of Health Studies, Technical University of Liberec, Liberec, Czech Republic (D.W., J. Kautzner, R.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Sedlakova","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Regional Hospital Liberec, Liberec, Czech Republic (T.R., P.K., P.N., J. Kupec, J. Sedlakova, J.C., J. Stros, R.P.); Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (D.W., J. Kautzner); and Institute of Health Studies, Technical University of Liberec, Liberec, Czech Republic (D.W., J. Kautzner, R.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Cerny","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Regional Hospital Liberec, Liberec, Czech Republic (T.R., P.K., P.N., J. Kupec, J. Sedlakova, J.C., J. Stros, R.P.); Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (D.W., J. Kautzner); and Institute of Health Studies, Technical University of Liberec, Liberec, Czech Republic (D.W., J. Kautzner, R.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Stros","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Regional Hospital Liberec, Liberec, Czech Republic (T.R., P.K., P.N., J. Kupec, J. Sedlakova, J.C., J. Stros, R.P.); Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (D.W., J. Kautzner); and Institute of Health Studies, Technical University of Liberec, Liberec, Czech Republic (D.W., J. Kautzner, R.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Kautzner","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Regional Hospital Liberec, Liberec, Czech Republic (T.R., P.K., P.N., J. Kupec, J. Sedlakova, J.C., J. Stros, R.P.); Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (D.W., J. Kautzner); and Institute of Health Studies, Technical University of Liberec, Liberec, Czech Republic (D.W., J. Kautzner, R.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rostislav","family":"Polasek","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Regional Hospital Liberec, Liberec, Czech Republic (T.R., P.K., P.N., J. Kupec, J. Sedlakova, J.C., J. Stros, R.P.); Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (D.W., J. Kautzner); and Institute of Health Studies, Technical University of Liberec, Liberec, Czech Republic (D.W., J. 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