{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:11:06Z","timestamp":1791490266879,"version":"4.3.4"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Catheter ablation (CA) of ventricular tachycardia (VT) in patients with nonischemic dilated cardiomyopathy can be challenging because of the complexity of underlying substrates. We sought to determine the long-term outcomes of endocardial and adjuvant epicardial CA in nonischemic dilated cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>We examined 282 consecutive patients (aged 59\u00b115 years, 80% males) with nonischemic dilated cardiomyopathy who underwent CA. Ablation was guided by activation\/entrainment mapping for tolerated VT and pacemapping\/targeting of abnormal electrograms for unmappable VT. Adjuvant epicardial ablation was performed for recurrent VT or persistent inducibility after endocardial\u2013only ablation. Epicardial ablation was performed in 90 (32%) patients. Before ablation, patients failed a median of 2 antiarrhythmic drugs), including amiodarone, in 166 (59%) patients. The median follow-up after the last procedure was 48 (19\u201367) months. Overall, VT-free survival was 69% at 60-month follow-up. Transplant-free survival was 76% and 68% at 60- and 120-month follow-up, respectively. Among the 58 (21%) patients with VT recurrence, CA still resulted in a significant reduction of VT burden, with 31 (53%) patients having only isolated (1\u20133) VT episodes in 12 (4\u201335) months after the procedure. At the last follow-up, 128 (45%) patients were only on \u03b2-blockers or no treatment, 41 (15%) were on sotalol or class I antiarrhythmic drugs, and 62 (22%) were on amiodarone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>In patients with nonischemic dilated cardiomyopathy and VT, endocardial and adjuvant epicardial CA is effective in achieving long-term VT freedom in 69% of cases, with a substantial improvement in VT burden in many of the remaining patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circep.116.004328","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T22:59:51Z","timestamp":1476313191000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":123,"title":["Long-Term Outcome After Catheter Ablation of Ventricular Tachycardia in Patients With Nonischemic Dilated Cardiomyopathy"],"prefix":"10.1161","volume":"9","author":[{"given":"Daniele","family":"Muser","sequence":"first","affiliation":[{"name":"From the Cardiac Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Santangeli","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A.","family":"Castro","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev K.","family":"Pathak","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson J.","family":"Liang","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Hayashi","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Magnani","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fermin C.","family":"Garcia","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Section, Hospital of the University of Pennsylvania, 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