{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:15:08Z","timestamp":1780445708365,"version":"3.54.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Atrioventricular nodal reentrant tachycardia (AVNRT) is considered a sporadic disease occurring in \u224822.5 cases per 10\u2009000 in the general population. We define the prevalence and characteristics of familial AVNRT among patients who underwent radiofrequency ablation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Ablation reports of all patients with familial AVNRT (at least 2 first-degree family members) who underwent radiofrequency ablation in our institution and in another hospital were reviewed. There were 1587 patients from our institution, of whom 20 had \u22651 first-degree relatives with AVNRT. This indicates a familial AVNRT prevalence of 127 cases per 10\u2009000 (95% confidence interval, 82\u2013196\/10\u2009000). First-degree relatives of patients with AVNRT presented a hazard ratio of at least 3.6 for exhibiting AVNRT compared with the general population. After inclusion of 4 families with familial AVNRT who underwent ablation at another hospital our population study comprised a total of 24 families (50 patients) with AVNRT. Patients at ablation were younger in the familial AVNRT group when compared with the sporadic AVNRT group (44.2\u00b119 versus 54.8\u00b118 years old,\n              <jats:italic>P<\/jats:italic>\n              =0.0001). The male\/female ratio was similar, with female predominance. The supraventricular tachycardia mechanism was typical slow\/fast reentry in most cases in both groups. The most common familial relationship in our 24 families included a parent and a child in 67% of cases and less often 2 siblings (29%).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Familial AVNRT prevalence is higher than previously believed suggesting that this arrhythmia may have a genetic component. Autosomal dominance with incomplete penetrance is the most likely mode of inheritance.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.116.004680","type":"journal-article","created":{"date-parts":[[2017,2,18]],"date-time":"2017-02-18T02:35:23Z","timestamp":1487385323000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Familial Occurrence of Atrioventricular Nodal Reentrant Tachycardia"],"prefix":"10.1161","volume":"10","author":[{"given":"Yoav","family":"Michowitz","sequence":"first","affiliation":[{"name":"From the Department of Cardiology and Tel-Aviv Sourasky Medical Center (Y.M., A.A.-H., O.T.-B., A.G., B.B.), and the Genetic Institute, Meir Medical Center (E.R.), Sackler Faculty of Medicine, Tel-Aviv University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Anis-Heusler","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology and Tel-Aviv Sourasky Medical Center (Y.M., A.A.-H., O.T.-B., A.G., B.B.), and the Genetic Institute, Meir Medical Center (E.R.), Sackler Faculty of Medicine, Tel-Aviv University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Reinstein","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology and Tel-Aviv Sourasky Medical Center (Y.M., A.A.-H., O.T.-B., A.G., B.B.), and the Genetic Institute, Meir Medical Center (E.R.), Sackler Faculty of Medicine, Tel-Aviv University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oholi","family":"Tovia-Brodie","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology and Tel-Aviv Sourasky Medical Center (Y.M., A.A.-H., O.T.-B., A.G., B.B.), and the Genetic Institute, Meir Medical Center (E.R.), Sackler Faculty of Medicine, Tel-Aviv University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aharon","family":"Glick","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology and Tel-Aviv Sourasky Medical Center (Y.M., A.A.-H., O.T.-B., A.G., B.B.), and the Genetic Institute, Meir Medical Center (E.R.), Sackler Faculty of Medicine, Tel-Aviv University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Belhassen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology and Tel-Aviv Sourasky Medical Center (Y.M., A.A.-H., O.T.-B., A.G., B.B.), and the Genetic Institute, Meir Medical Center (E.R.), Sackler Faculty of Medicine, Tel-Aviv University, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1111259"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00422-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2004.00388.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2012.42.10.718"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0972-6292(16)30589-7"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.5603\/KP.2015.0249"},{"key":"e_1_3_3_8_2","first-page":"455","article-title":"Radiofrequency ablation of atrioventricular nodal reentry tachycardia: a 14 year experience with 901 patients at the Tel Aviv Sourasky Medical Center.","volume":"8","author":"Topilski I","year":"2006","unstructured":"Topilski I, Rogowski O, Glick A, Viskin S, Eldar M, Belhassen B. 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