{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:42:41Z","timestamp":1782981761017,"version":"3.54.5"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Pulmonary vein isolation (PVI) is effective for maintenance of sinus rhythm in 50% to 75% of patients with paroxysmal atrial fibrillation, and it is not uncommon for patients to require additional ablation after PVI. We prospectively evaluated the relative effectiveness of 2 post-PVI ablation strategies in paroxysmal atrial fibrillation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              A total of 500 patients (mean age, 55.7\u00b111.0 years; 74.6% male) were randomly assigned to undergo ablation by 2 different strategies after PVI: (1) elimination of non-PV triggers (group A, n=250) or (2) stepwise substrate modification including complex fractionated atrial electrogram or linear ablation until noninducibility of atrial tachyarrhythmia was achieved (group B, n=250). During a median follow-up of 26.0 months, 75 (32.2%) patients experienced at least 1 episode of recurrent atrial tachyarrhythmia after the single procedure in group A compared with 105 (43.8%) patients in group B (\n              <jats:italic>P<\/jats:italic>\n              value in log-rank test of Kaplan\u2013Meier analysis: 0.012). Competing risk analysis showed that the cumulative incidence of atrial tachycardia was significantly higher in group B compared with group A (\n              <jats:italic>P<\/jats:italic>\n              =0.007). With the exception of total ablation time, there were no significant differences in fluoroscopic time or procedure-related complications between the 2 groups.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Elimination of triggers as an end point of ablation in patients with paroxysmal atrial fibrillation decreased long-term recurrence of atrial tachyarrhythmia compared with a noninducibility approach achieved by additional empirical ablation. The post-PVI trigger test is thus a better end point of ablation for paroxysmal atrial fibrillation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.117.005019","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T09:48:26Z","timestamp":1518083306000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Long-Term Clinical Comparison of Procedural End Points After Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation"],"prefix":"10.1161","volume":"11","author":[{"given":"Kwang-No","family":"Lee","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul, Republic of Korea (K.-N.L., S.-Y.R., Y.-S.B., H.-S.P., J.S., J.-I.C., Y.-H.K.); Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea (J.A.); Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea (D.-H.K., S.-W.P.); and Division of Cardiology, Department of Internal Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Young","family":"Roh","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul, Republic of Korea (K.-N.L., S.-Y.R., Y.-S.B., H.-S.P., J.S., J.-I.C., Y.-H.K.); Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea (J.A.); Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea (D.-H.K., S.-W.P.); and Division of Cardiology, Department of Internal Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Soo","family":"Baek","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul, Republic of Korea (K.-N.L., S.-Y.R., Y.-S.B., H.-S.P., J.S., J.-I.C., Y.-H.K.); Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea (J.A.); Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea (D.-H.K., S.-W.P.); and Division of Cardiology, Department of Internal Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Soon","family":"Park","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul, Republic of Korea (K.-N.L., S.-Y.R., Y.-S.B., H.-S.P., J.S., J.-I.C., Y.-H.K.); Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea (J.A.); Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea (D.-H.K., S.-W.P.); and Division of Cardiology, Department of Internal Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhee","family":"Ahn","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul, Republic of Korea (K.-N.L., S.-Y.R., Y.-S.B., H.-S.P., J.S., J.-I.C., Y.-H.K.); Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea (J.A.); Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea (D.-H.K., S.-W.P.); and Division of Cardiology, Department of Internal Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hyeok","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul, Republic of Korea (K.-N.L., S.-Y.R., Y.-S.B., H.-S.P., J.S., J.-I.C., Y.-H.K.); Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea (J.A.); Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea (D.-H.K., S.-W.P.); and Division of Cardiology, Department of Internal Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae In","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul, Republic of Korea (K.-N.L., S.-Y.R., Y.-S.B., H.-S.P., J.S., J.-I.C., Y.-H.K.); Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea (J.A.); Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea (D.-H.K., S.-W.P.); and Division of Cardiology, Department of Internal Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaemin","family":"Shim","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul, Republic of Korea (K.-N.L., S.-Y.R., Y.-S.B., H.-S.P., J.S., J.-I.C., Y.-H.K.); Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea (J.A.); Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea (D.-H.K., S.-W.P.); and Division of Cardiology, Department of Internal Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Il","family":"Choi","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul, Republic of Korea (K.-N.L., S.-Y.R., Y.-S.B., H.-S.P., J.S., J.-I.C., Y.-H.K.); Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea (J.A.); Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea (D.-H.K., S.-W.P.); and Division of Cardiology, Department of Internal Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Weon","family":"Park","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul, Republic of Korea (K.-N.L., S.-Y.R., Y.-S.B., H.-S.P., J.S., J.-I.C., Y.-H.K.); Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea (J.A.); Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Republic of Korea (D.-H.K., S.-W.P.); and Division of Cardiology, Department of Internal 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