{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:20:02Z","timestamp":1790695202637,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Repolarization abnormalities in arrhythmogenic right ventricular (RV) cardiomyopathy and their relationship to ventricular tachycardia substrate are incompletely understood.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              In 40 patients (29 men, mean age 38 years) with arrhythmogenic RV cardiomyopathy, we compared the extent and location of abnormal T (NegT) waves \u22651 mm in depth (n=32) and downsloping elevated ST segment (n=13), in \u22652 adjacent leads, to area and location of endocardial bipolar (&lt;1.5 mV) and unipolar (&lt;5.5 mV) and epicardial bipolar (&lt;1.0 mV) voltage abnormalities. Abnormal unipolar RV endocardial area of 33.4\u00b119.3% was present in 8 patients without NegT waves. Patients with NegT waves extending beyond lead V\n              <jats:sub>3<\/jats:sub>\n              (n=20) had larger low bipolar (31.4\u00b118.9% versus 16.5\u00b114.6%;\n              <jats:italic>P<\/jats:italic>\n              =0.008) and unipolar endocardial areas (66.0\u00b119.6% versus 47.4\u00b125.1%;\n              <jats:italic>P<\/jats:italic>\n              =0.013) and larger epicardial low bipolar area (56.0\u00b119.3% versus 40.1\u00b124.9%;\n              <jats:italic>P<\/jats:italic>\n              =0.030) compared with those with NegT waves limited to leads V\n              <jats:sub>1<\/jats:sub>\n              through V\n              <jats:sub>3<\/jats:sub>\n              (n=20). ECG location of NegT waves regionalized to location of substrate. Patients with downsloping elevated ST segment, all localized to leads V\n              <jats:sub>1<\/jats:sub>\n              and V\n              <jats:sub>2<\/jats:sub>\n              , had more unipolar endocardial abnormalities (71.8\u00b118.1% versus 49.4\u00b123.5%;\n              <jats:italic>P<\/jats:italic>\n              =0.005) involving outflow and mid-RV, compared with patients without downsloping elevated ST segment.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>\n              In arrhythmogenic RV cardiomyopathy, abnormal electroanatomic mapping areas are proportional to extent of T-wave inversion on 12-lead ECG. Marked voltage abnormalities can exist without repolarization change. Downsloping elevated ST-segment pattern in V\n              <jats:sub>1<\/jats:sub>\n              and V\n              <jats:sub>2<\/jats:sub>\n              occurs with more unipolar endocardial voltage abnormality, consistent with more advanced transmural disease.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.117.005553","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T09:20:18Z","timestamp":1521105618000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Electrocardiographic Repolarization Abnormalities and Electroanatomic Substrate in Arrhythmogenic Right Ventricular Cardiomyopathy"],"prefix":"10.1161","volume":"11","author":[{"given":"Maciej","family":"Kubala","sequence":"first","affiliation":[{"name":"From the Cardiac Electrophysiology Program, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev K.","family":"Pathak","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Program, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanglun","family":"Xie","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Program, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Casado Arroyo","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Program, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory M.","family":"Tschabrunn","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Program, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Hayashi","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Program, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fermin C.","family":"Garcia","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Program, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory E.","family":"Supple","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Program, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Santangeli","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Program, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Frankel","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Program, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica S.","family":"Zado","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology Program, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Callans","sequence":"additional","affiliation":[{"name":"From the Cardiac Electrophysiology 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