{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:22:08Z","timestamp":1783351328032,"version":"3.54.6"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>In human long-standing persistent atrial fibrillation, rotors potentially explain atrial fibrillation maintenance, but their ablation remains controversial. We aimed to explore original phase\/frequency mapping methods to locate rotors and track changes induced by their ablation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              Thirteen patients with long-standing persistent atrial fibrillation (duration, 12\u201372 months) underwent phase\/frequency mapping (Hilbert\/Fourier transforms; CARTO-Finder) of the left and right atria (PentaRay catheter). A rotor domain was defined as an area displaying at least 3 consecutive rotations. Ablation was performed by circumferential pulmonary vein isolation plus linear ablation of extrapulmonary rotor domains. We identified 19 rotor domains in 10 patients (1.8\u00b11.1 per patient; 7 in the right atrium versus 12 in the left atrium; 15 extrapulmonary). Overall, rotor domains (9.2\u00b12.2 rotations) displayed higher frequency of activation (6.41 Hz; 95% confidence interval, 6.24\u20136.57) than nonrotor domains (6.17 Hz; 95% confidence interval, 6.1\u20136.23;\n              <jats:italic>P<\/jats:italic>\n              =0.021), with interatrial frequency gradients established by the spatial location of the rotor domain (\n              <jats:italic>P<\/jats:italic>\n              =0.016). Fibrillatory conduction was suggested as a decrease in the frequency of the slower atria after ablation close to main interatrial conduction fascicles (\n              <jats:italic>P<\/jats:italic>\n              =0.035). Ablation of rotor domains (ablation line, 3.5\u00b10.9 cm) effectively decreased the frequency of activation in both ipsilateral and contralateral atria (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05 for both), whereas ablation of nonrotor domains did not. Acute conversion to sinus rhythm was observed in 2 patients after ablation of rotor domains. At 1-year follow-up, 70% remained in sinus rhythm (85% out-of-antiarrhythmic drugs).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Rotor domains appropriately explain long-standing persistent atrial fibrillation physiology at its frequency content. Their ablation effectively modifies dynamics on restricted ablation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.117.005740","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T01:10:22Z","timestamp":1513645822000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Ablation of Rotor Domains Effectively Modulates Dynamics of Human"],"prefix":"10.1161","volume":"10","author":[{"given":"David","family":"Calvo","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Arrhythmia Unit, Hospital Universitario Central de Asturias, Oviedo, Spain; and Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, Oviedo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Rub\u00edn","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Arrhythmia Unit, Hospital Universitario Central de Asturias, Oviedo, Spain; and Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, Oviedo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Arrhythmia Unit, Hospital Universitario Central de Asturias, Oviedo, Spain; and Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, Oviedo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Mor\u00eds","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Arrhythmia Unit, Hospital Universitario Central de Asturias, Oviedo, Spain; and Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, Oviedo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000040"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408288"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv233"},{"key":"e_1_3_3_5_2","first-page":"256","article-title":"Mechanistic comparison of \u201cnearly missed\u201d versus \u201con-target\u201d rotor ablation.","volume":"1","author":"Masatoshi Y","year":"2015","unstructured":"Masatoshi Y, Uma Mahesh R. 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