{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:45:47Z","timestamp":1788317147456,"version":"build-2803163510"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>An improved knowledge of the spatial organization of infarct structure and its contribution to ventricular tachycardia (VT) is important for designing optimal treatments. This study explores the relationship between the 3-dimensional structure of the healed infarct and the VT reentrant pathways in high-resolution models of infarcted porcine hearts.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              Structurally detailed models of infarcted ventricles were reconstructed from ex vivo late gadolinium enhancement and diffusion tensor magnetic resonance imaging data of 8 chronically infarcted porcine hearts at submillimeter resolution (0.25\u00d70.25\u00d70.5 mm\n              <jats:sup>3<\/jats:sup>\n              ). To characterize the 3-dimensional structure of surviving tissue in the zone of infarct, a novel scar-mapped thickness metric was introduced. Further, using the ventricular models, electrophysiological simulations were conducted to determine and analyze the 3-dimensional VT pathways that were established in each of the complex infarct morphologies.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The scar-mapped thickness metric revealed the heterogeneous organization of infarct and enabled us to systematically characterize the distribution of surviving tissue thickness in 8 hearts. Simulation results demonstrated the involvement of a subendocardial tissue layer of varying thickness in the majority of VT pathways. Importantly, they revealed that VT pathways are most frequently established within thin surviving tissue structures of thickness \u22642.2 mm (90th percentile) surrounding the scar.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The combination of high-resolution imaging data and ventricular simulations revealed the 3-dimensional distribution of surviving tissue surrounding the scar and demonstrated its involvement in VT pathways. The new knowledge obtained in this study contributes toward a better understanding of infarct-related VT.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.117.006131","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T09:05:19Z","timestamp":1528362319000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Role of 3-Dimensional Architecture of Scar and Surviving Tissue in Ventricular Tachycardia"],"prefix":"10.1161","volume":"11","author":[{"given":"Farhad","family":"Pashakhanloo","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering (F.P., D.A.H., E.R.M., N.A.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Herzka","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering (F.P., D.A.H., E.R.M., N.A.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Halperin","sequence":"additional","affiliation":[{"name":"Department of Medicine (H.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot R.","family":"McVeigh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering (F.P., D.A.H., E.R.M., N.A.T.)"},{"name":"Johns Hopkins University, Baltimore, MD. Departments of Bioengineering, Medicine, and Radiology, University of California, San Diego, La Jolla (E.R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia A.","family":"Trayanova","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering (F.P., D.A.H., E.R.M., N.A.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61413-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1989.69.4.1049"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2003"},{"key":"e_1_3_3_5_2","first-page":"446","volume-title":"Clinical Cardiac Electrophysiology: Techniques and Interpretations","author":"Josephson ME","year":"2008","unstructured":"Josephson MEClinical Cardiac Electrophysiology: Techniques and Interpretations. 4th ed. 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