{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:04:52Z","timestamp":1793883892704,"version":"4.7.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The frequency of cardiac rhythm abnormalities and their risk factors in community-dwelling adults are not well characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We determined the frequency of rhythm abnormalities in the UK Biobank, a national prospective cohort. We tested associations between risk factors and incident rhythm abnormalities using multivariable proportional hazards regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 502 627 adults (median age, 58 years [interquartile range, 13]; 54.4% women), 2.35% had a baseline rhythm abnormality. The prevalence increased with age with 4.84% of individuals aged 65 to 73 years affected. During 3 368 332 person-years of follow-up, 15 906 new rhythm abnormalities were detected (4.72 per 1000 person-years; 95% confidence interval [CI]: 4.65\u20134.80). Atrial fibrillation (3.11 per 1000 person-years; 95% CI: 3.05\u20133.17), bradyarrhythmias (0.89 per 1000 person-years; 95% CI: 0.86\u20130.92), and conduction system diseases (1.06 per 1000 person-years; 95% CI: 1.02\u20131.09) were more common than supraventricular (0.51 per 1000 person-years; 95% CI: 0.48\u20130.53) and ventricular arrhythmias (0.57 per 1000 person-years; 95% CI: 0.55\u20130.60). Older age (hazard ratio [HR]: 2.35 per 10-year increase; 95% CI: 2.29\u20132.41;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01), male sex (HR: 1.83; 95% CI: 1.76\u20131.89;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01), hypertension (HR: 1.49; 95% CI: 1.44\u20131.54;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01), chronic kidney disease (HR: 1.95; 95% CI: 1.67\u20132.27;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01), and heart failure (HR: 1.99; 95% CI: 1.76\u20132.26;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01) were associated with new rhythm abnormalities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The frequency of rhythm abnormalities in middle-aged to older community-dwelling adults is substantial. Atrial fibrillation, bradyarrhythmias, and conduction system diseases account for most rhythm conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circep.118.006273","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T05:06:41Z","timestamp":1530162401000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":252,"title":["Frequency of Cardiac Rhythm Abnormalities in a Half Million Adults"],"prefix":"10.1161","volume":"11","author":[{"given":"Shaan","family":"Khurshid","sequence":"first","affiliation":[{"name":"Division of Cardiology (S.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hoan","family":"Choi","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center (S.H.C., L.-C.W., E.Y.W., P.T.E., S.A.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Chen","family":"Weng","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center (S.H.C., L.-C.W., E.Y.W., P.T.E., S.A.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center (S.H.C., L.-C.W., E.Y.W., P.T.E., S.A.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Trinquart","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston. Department of Biostatistics, Boston University School of Public Health, MA (L.T.)"},{"name":"Boston University and National Heart, Lung, and Blood Institute\u2019s Framingham Heart Study, MA (L.T., E.J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelia J.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Boston University and National Heart, Lung, and Blood Institute\u2019s Framingham Heart Study, MA (L.T., E.J.B.)."},{"name":"Sections of Preventive Medicine and Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (E.J.B.)"},{"name":"Department of Epidemiology, Boston University School of Public Heath, MA (E.J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick T.","family":"Ellinor","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center (S.H.C., L.-C.W., E.Y.W., P.T.E., S.A.L.)"},{"name":"Cardiac Arrhythmia Service (P.T.E., S.A.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Lubitz","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center (S.H.C., L.-C.W., E.Y.W., P.T.E., S.A.L.)"},{"name":"Cardiac Arrhythmia Service (P.T.E., S.A.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.18.2370"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000121736.16643.11"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01236-6"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1987.00370090041008"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00422-1"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1197\/j.aem.2007.01.013"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318276ce9b"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2008.06.003"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.15"},{"key":"e_1_3_4_12_2","unstructured":"UK Biobank. Protocol for a Large-Scale Prospective Epidemiological Resource. 2006.www.ukbiobank.ac.uk\/resources\/. Accessed June 9 2017."},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_3_4_14_2","article-title":"UK B iobank: opportunities for cardiovascular research [published online ahead of print May 20, 2017].","author":"Littlejohns TJ","unstructured":"Littlejohns, TJ, Sudlow, C, Allen, NE, Collins, R. UK B iobank: opportunities for cardiovascular research [published online ahead of print May 20, 2017]. Eur Heart J. doi 10.1093\/eurheartj\/ehx254. https:\/\/academic.oup.com\/eurheartj\/advance-article\/doi\/10.1093\/eurheartj\/ehx254\/3836952.","journal-title":"Eur Heart J"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx246"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000309"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.10.031"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.07.017"},{"key":"e_1_3_4_19_2","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2015","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria; R Foundation for Statistical Computing. 2015. https:\/\/www.R-project.org\/. Accessed June 9, 2017."},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000140263.20897.42"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.056"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.595140"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux322"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0909392"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2014.06.007"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2014.902748"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.000102"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4950250203"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61774-8"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/28114"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-11-0768"}],"container-title":["Circulation: Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.118.006273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T03:21:12Z","timestamp":1738812072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.118.006273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1161\/CIRCEP.118.006273"],"URL":"https:\/\/doi.org\/10.1161\/circep.118.006273","relation":{},"ISSN":["1941-3149","1941-3084"],"issn-type":[{"value":"1941-3149","type":"print"},{"value":"1941-3084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"2018-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e006273"}}