{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:43:38Z","timestamp":1773074618273,"version":"3.50.1"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Implantable cardioverter defibrillators (ICDs) are an important part of therapy for many patients, yet there is little data on population characteristics, complications, or system survival in pediatric patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A retrospective review of ICD recipients in the National Cardiovascular Data Registry ICD Registry was performed from 2010 to 2016. Patient characteristics and complications between pediatric (\u226421 years) and adult populations (&gt;21 years) were compared. Variables associated with complications and early device interventions within the pediatric cohort were evaluated using multivariate modeling.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>\n              There were 562 209 total ICD implants, of which 3461 occurred in the pediatric cohort. Among the pediatric patients, 60% of implants were for primary prevention, and nonischemic cardiomyopathy was the most common underlying disease (60%). Over time, there was an increasing trend of both primary and secondary prevention ICD implantations (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). Compared with adults, pediatric patients were more likely to have structural heart disease, hypertrophic cardiomyopathy, and channelopathy, and to receive a single-chamber device (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). There was no difference in inhospital complications between the adult and pediatric cohorts (2.4% versus 2.6%,\n              <jats:italic>P<\/jats:italic>\n              =0.3). However, among the pediatric patients, lower weight, Ebstein anomaly, worse New York Heart Association class, dual chamber, and cardiac resynchronization therapy-defibrillator were associated with greater risk of complications. Although reintervention for generator replacement or upgrade was more common in adults, the time to reintervention was shorter in the pediatric cohort.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>We observed an increasing trend in ICD device implantation among pediatric patients. The pediatric cohort had similar inhospital complication rates compared with adults but had a shorter time to reintervention.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.118.006542","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T13:34:48Z","timestamp":1537104888000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Characteristics and Outcomes of Pediatric Patients Who Undergo Placement of Implantable Cardioverter Defibrillators"],"prefix":"10.1161","volume":"11","author":[{"given":"Shankar","family":"Baskar","sequence":"first","affiliation":[{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, OH (S.B., D.S.S., R.J.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haikun","family":"Bao","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research and Evaluation, Yale-New Haven Health Services Corporation, CT (H.B., K.E.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl E.","family":"Minges","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research and Evaluation, Yale-New Haven Health Services Corporation, CT (H.B., K.E.M.)."},{"name":"Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (K.E.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Spar","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, OH (S.B., D.S.S., R.J.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Czosek","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, OH (S.B., D.S.S., 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Arrhythmia and Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCEP.118.006542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:32:27Z","timestamp":1715556747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCEP.118.006542"}},"subtitle":["Insights From the National Cardiovascular Data 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