{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:06:30Z","timestamp":1785150390834,"version":"3.55.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Arrhythmia and Electrophysiology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Biatrial, extensive, and complex ablation strategies have been published for the treatment of neurally mediated syncope, sinus node dysfunction, and functional atrioventricular block. We have developed a less extensive and more specific approach compared with previously published cardioneuroablation strategies, called cardio-neuromodulation. It is based on tailored vagolysis of the sinoatrial node through partial ablation of the anterior right-ganglionated plexus, preferentially through a right-sided approach.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec sec-type=\"methods\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Patients with syncope were enrolled between December 2016 and December 2017. They were assigned to group A if they had a positive head-up tilt test and to group B if they presented with a pause \u22653 seconds. The area to target during cardio-neuromodulation was designed offline on a computed tomographic scan. Slow heart rates and pauses were compared during 24-hour rhythm registration at baseline, at 1-month follow-up, and 6-month follow-up. Syncope burden was assessed before the procedure and at 3- and 6-month follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec sec-type=\"results\">\n            <jats:title>Results<\/jats:title>\n            <jats:p>\n              Twenty patients underwent cardio-neuromodulation through a right-sided approach (12 in group A, 8 in group B). The first application of radiofrequency energy led to a P-P interval shortening &gt;120 ms in all 20 patients. After a mean\u00b1SD ablation time of 7\u00b14 minutes and mean ablated surface area of 11\u00b16 mm\n              <jats:sup>2<\/jats:sup>\n              , the P-P interval shortened by 219\u00b1160 ms (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The number of beats &lt;50\/min during 24-hour rhythm registration was reduced by a median of 100% at 6-month follow-up (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Syncope burden was reduced by 95% at 6-month follow-up (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>These data indicate that cardio-neuromodulation, through a right-sided and computed tomographic\u2013guided procedure, is safe, fast, and highly reproducible in preventing inappropriate functional sinus bradycardia and syncope recurrence.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circep.118.006604","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T13:34:48Z","timestamp":1537104888000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":99,"title":["Unifocal Right-Sided Ablation Treatment for Neurally Mediated Syncope and Functional Sinus Node Dysfunction Under Computed Tomographic Guidance"],"prefix":"10.1161","volume":"11","author":[{"given":"Philippe","family":"Debruyne","sequence":"first","affiliation":[{"name":"Department of Cardiology, Imeldaziekenhuis, Bonheiden, Belgium (P.D., T.R., J.R., B.E., L.J., F.C., B.V., W.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Rossenbacker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Imeldaziekenhuis, Bonheiden, Belgium (P.D., T.R., J.R., B.E., L.J., F.C., B.V., W.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Collienne","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Cliniques Universitaires Saint-Luc, Woluwe, Belgium (C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Roosen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Imeldaziekenhuis, Bonheiden, Belgium (P.D., T.R., J.R., B.E., L.J., F.C., B.V., W.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bavo","family":"Ector","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Imeldaziekenhuis, Bonheiden, Belgium (P.D., T.R., J.R., B.E., L.J., F.C., B.V., W.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Janssens","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Imeldaziekenhuis, Bonheiden, Belgium (P.D., T.R., J.R., B.E., L.J., F.C., B.V., W.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Charlier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Imeldaziekenhuis, Bonheiden, Belgium (P.D., T.R., J.R., B.E., L.J., F.C., B.V., W.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Vankelecom","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Imeldaziekenhuis, Bonheiden, Belgium (P.D., T.R., J.R., B.E., L.J., F.C., B.V., W.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"Dewilde","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Imeldaziekenhuis, Bonheiden, Belgium (P.D., T.R., J.R., B.E., L.J., F.C., B.V., W.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wijns","sequence":"additional","affiliation":[{"name":"The Lambe Institute for Translational Medicine and Curam, National University of Ireland, Galway and Saolta University Healthcare Group (W.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","first-page":"198","article-title":"Selective vagal innervation of the heart.","volume":"16","author":"Randall WC","year":"1986","unstructured":"Randall, WC, Milosavljevic, M, Wurster, RD, Geis, GS, Ardell, JL. 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